Combination of nerve blockade and intravenous alfentanil is better than single treatment in relieving postoperative pain

Wen, Yeong-Ray; Lin, Chih-Peng; Tsai, Ming-Dar; Chen, Jui-Yuan; Ma, Chih-Chun; Sun, Wei‐Zen; Wang, Chia–Chuan

doi:10.1016/j.jfma.2011.02.001

Cited by 2 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Local anesthesia, including LIA and regional nerve block, has been found to prevent the development of postoperative pain at least during the acute postoperative period (4,20,21). The inhibitory effect on postoperative pain by local anesthesia may be mediated by preventing the transmission of nociceptive stimuli from the peripheral to the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia

Lu¹,

Ye²,

Luo³

et al. 2018

BST

View full text Add to dashboard Cite

Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar incision after the second injection or they received pre-incision LIA and sciatic nerve block (SNB) or post-incision LIA with levobupivacaine (0.5%, 0.2 mL). Mechanical and thermal nociceptive thresholds were assessed using the tail pressure test and paw withdrawal test on the day before drug injection, 1 and 4 hours after injection, and 1-7 days later. The lumbar spinal cord and dorsal root ganglia were collected from rats in each group to measure IL-1β, IL-6, and TNF-α on the day before drug injection, 4 hours after injection, and 1, 3, 5, and 7 days later. Fentanyl and an incision induced a significantly delayed mechanical hyperalgesia in the tail and thermal hyperalgesia in both hind paws and up-regulation of pro-inflammatory cytokines in the spinal cord and dorsal root ganglia. Rats treated with pre-incision LIA and SNB or post-incision LIA had alleviated hyperalgesia and significantly reduced levels of IL-1β, IL-6, and TNF-α compared to the control group. LIA and SNB partly prevented perioperative fentanyl-induced hyperalgesia and up-regulation of pro-inflammatory cytokines in the spinal cord and dorsal root ganglia.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia

Lu¹,

Ye²,

Luo³

et al. 2018

BST

View full text Add to dashboard Cite

show abstract

“…Pentobarbital, where available, is less reliable but can be useful for non-recovery applications. Local anesthesia is a useful addition to multimodal analgesia (Wen et al, 2012). Its side-effects, such as pica, can be minimized by altering the dose schedule and utilizing a multimodal approach (Schaap et al, 2012).…”

Section: Ratsmentioning

confidence: 99%

Preanesthesia, Anesthesia, Analgesia, and Euthanasia

Flecknell

Lofgren

Dyson

et al. 2015

Laboratory Animal Medicine

View full text Add to dashboard Cite

Combination of nerve blockade and intravenous alfentanil is better than single treatment in relieving postoperative pain

Abstract: Our results indicated that in an incisional pain model, multimodal analgesia is superior to single or no pretreatment; however, the combination of multimodal analgesic treatments should be individually discerned depending on nociceptive types and analgesic mechanisms.

Cited by 2 publications

References 44 publications

Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia

Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia

Preanesthesia, Anesthesia, Analgesia, and Euthanasia

Contact Info

Product

Resources

About