Combination of photothermal and photodynamic inactivation of cancer cells through surface plasmon resonance of a gold nanoring

Chu, Cheng Hung; Tu, Yi-Chou; Hsiao, Jen-Hung; Yu, Jian-He; Yu, Chih-Kang; Chen, Shih-Yang; Tseng, Po-Chih; Chen, Shuai; Kiang, Yean‐Woei; Yang, Chun‐Chen

doi:10.1088/0957-4484/27/11/115102

Cited by 49 publications

(42 citation statements)

References 53 publications

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“…However, the area that could be treated was too limited in size due to uneven distribution of the laser radiation. 192 Electrostatically formed nanocarriers can be used for cancer therapy. In Song et al’s study, DOX-loaded nanoassemblies based on J-aggregate of an organic NIR dye, IR825, were employed as a controlled and safe drug delivery system for combined cancer targeted chemotherapy and PTT.…”

Section: Applications Of Light As a Therapeutic In Cancer Nanomedimentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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Section: Applications Of Light As a Therapeutic In Cancer Nanomedimentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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“…Gold nanoparticles (AuNPs) have been used in two ways in PDT: first, as drug-delivery platforms in a similar manner to other inorganic NPs [69]; second, as surface plasmon-enhanced agents taking account of the non-linear optical fields associated with very close distances to metal NPs [70] (Figure 6). The AuNPs have good biocompatibility, versatile surfaces, and unique optical properties [71].…”

Section: Photodynamic Inactivation and Nanotechnologymentioning

confidence: 99%

“…Huang et al [201] also synthesized a highly water-soluble [70] fullerene monoadduct, C70[ > M(C3N6(+) C3)2]-(I(−))10 (LC17), and bisadduct, C70[ > M(C3N6(+) C3)2][ > M(C3N6C3)2] (LC18), both with a well-defined decacationic quaternary ammonium iodide moiety with 10 positive charges per C70 to give water solubility and bacterial binding. A mouse model of third-degree burn infection with bioluminescent Gram-negative bacteria was used to test the in vivo effectiveness of the therapeutic approach using the more effective UVA excitation.…”

Section: Apdi For Treating Localized Infectionsmentioning

confidence: 99%

Advances in antimicrobial photodynamic inactivation at the nanoscale

2017

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The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light. Photodynamic inactivation relies on the photochemical production of singlet oxygen from photosensitizing dyes (type II pathway) that can benefit remarkably from formulation in nanoparticle-based drug delivery vehicles. Fullerenes are a closed-cage carbon allotrope nanoparticle with a high absorption coefficient and triplet yield. Their photochemistry is highly dependent on microenvironment, and can be type II in organic solvents and type I (hydroxyl radicals) in a biological milieu. Titanium dioxide nanoparticles act as a large band-gap semiconductor that can carry out photo-induced electron transfer under ultraviolet A light and can also produce reactive oxygen species that kill microbial cells. We discuss some recent studies in which quite remarkable potentiation of microbial killing (up to six logs) can be obtained by the addition of simple inorganic salts such as the non-toxic sodium/potassium iodide, bromide, nitrite, and even the toxic sodium azide. Interesting mechanistic insights were obtained to explain this increased killing.

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“…One NP in particular that can be applied by covalent bonding of PSs to its surface is gold-NPs (Au-NPs). Au-NPs has enhanced surfaceplasmon resonance (SPR) effects due to the non-linear optical fields found in metal NPs being very close [58]. Au-NPs have good biocompatibility, versatile surfaces, and unique optical properties [59], whereby their optical field can be enhanced by the SPR by changing the shape of the NP specifically to a ring [60].…”

Section: Nanomedicine and Pdtmentioning

confidence: 99%

Targeted Photodynamic Therapy for Improved Lung Cancer Treatment

Crous¹,

Abrahamse²

2018

Lung Cancer - Strategies for Diagnosis and Treatment

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Cancer develops from the outgrowth of a clonal population of cells with a genetic pathology to evade cell death and exponential proliferation. It has become a global burden with increasing mortality rates. Lung cancer is a major contributor to cancer fatalities. Conventional therapies have shown advances in treating lung cancer, but the successful eradication of cancer lies in targeting both cancer and cancer stem cells. Cancer stem cells (CSCs) are a ration of cells found within the tumour bulk, capable of cancer initiation, therapy resistance, metastasis and cancer relapse. Photodynamic therapy (PDT) has proven effective in treating lung cancer. PDT exerts selective cell death mechanisms toward cancerous cells. With the use of a photosensitizer (PS) which becomes excited upon irradiation with laser light at a specific wavelength, the PS forms reactive oxygen species (ROS) in turn killing neoplastic cells. Leading therapeutic sequel can be obtained by transcending PDT though combination therapies such as immunotherapy and nanotechnology which will enable PDT to target lung CSCs preventing lung cancer recurrence.

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Combination of photothermal and photodynamic inactivation of cancer cells through surface plasmon resonance of a gold nanoring

Cited by 49 publications

References 53 publications

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Advances in antimicrobial photodynamic inactivation at the nanoscale

Targeted Photodynamic Therapy for Improved Lung Cancer Treatment

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