Combination of plasma-soluble fms-like tyrosine kinase 1 and uterine artery Doppler for the prediction of preeclampsia in cases of elderly gravida

Kulmala, Lalita; Phupong, Vorapong

doi:10.1038/hr.2014.27

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…Bolin et al [12] demonstrated that separate measurements of serum HRG and PI may predict pre-eclampsia, but by combining serum HRG and PI the accuracy increased. This is in line with this study in which a total accuracy of both reached 84.3% and in line with studies proposing a combination of biochemical and biophysical markers for a successful prediction of pre-eclampsia in early pregnancy [13,14,22,23].…”

Section: Figuresupporting

confidence: 92%

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Bassiouny¹,

El-Said²,

Mohamed³

et al. 2016

Evidence Based Womenʼs Health Journal

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ObjectivePre-eclampsia is accompanied by both maternal and neonatal complications. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory reactions, which are involved in the development of pre-eclampsia. We assessed the value of combining early second trimester maternal serum HRG and uterine artery Doppler in predicting pre-eclampsia. Patients and methods A total of 140 pregnant women were divided into two groups: group A (n = 70), a high-risk group, and group B (n = 70), a control group. They were subjected to measurement of maternal serum HRG at 16-18 weeks of gestation and uterine artery Doppler assessment at 20-22 weeks of gestation. All pregnancies were followed up until delivery for development of pre-eclampsia. ResultsThe cases that developed pre-eclampsia had lower serum levels of HRG and higher pulsatility index. Our cutoff value for serum HRG to predict pre-eclampsia was less than 40.6 mg/ml and the cutoff value for mean pulsatility index was less than 1.24. The sensitivity, specificity, positive predictive value, negative predictive value, and total accuracy of uterine artery Doppler combined with serum HRG for pre-eclampsia prediction were 71.4, 97.1, 96.1, 77.3, and 84.3%, respectively. Conclusion This combination test may be a useful early second trimester screening test for the prediction of pre-eclampsia.

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Section: Figuresupporting

confidence: 92%

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Bassiouny¹,

El-Said²,

Mohamed³

et al. 2016

Evidence Based Womenʼs Health Journal

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“…Several key events have been shown to be involved in the early development of PE, including insufficient spiral artery remodeling and higher plasma levels of soluble fms-like tyrosine kinase-1. Higher plasma levels of soluble fms-like tyrosine kinase-1 has been shown to antagonize vascular endothelial growth factor, which causes abnormal spiral artery remodeling [31][32][33] ; therefore, vascular endothelial growth factor inhibitors have been used as a model of PE. 34,35 In addition, based on two predominant theories of PE (the locally chronic uterine placenta ischemia and hypoxia theory and the excessive activation of the maternal immune system theory), additional animal models of PE have been developed.…”

Section: The Effect Of Mgso 4 On the Pe And Seizure Modelsmentioning

confidence: 99%

Increased neuronal seizure activity correlates with excessive systemic inflammation in a rat model of severe preeclampsia

et al. 2016

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Preeclampsia (PE), one of the most common disorders of pregnancy, is characterized by hypertension and albuminuria. In severe cases, PE results in eclampsia-like seizures. Studies have suggested that severe PE is related to an exaggerated systemic inflammatory response, which may increase sensitivity to seizures. In the current study, we investigated whether the seizure activity of neurons was enhanced under excessive systemic inflammation. We also sought to determine whether MgSO could reduce the effects of systemic inflammation on seizure activity after electrical stimulation in a lipopolysaccharide (LPS)-induced model of PE. In addition to pregnancy outcomes, we analyzed biochemical parameters to ascertain whether our PE model was successful. Enzyme-linked immunosorbent assay analysis revealed that the levels of inflammatory cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-1β) were significantly higher in the LPS-treated rats than in the untreated rats. After electrical stimulation, behavioral assessments showed that the LPS-treated rats that were not treated with MgSO had the shortest latency period to develop a seizure and the longest seizure duration. The electroencephalographic (EEG) recordings in the hippocampus demonstrated that this group also had the highest EEG amplitude. MgSO treatment significantly decreased both TNF-α and IL-1β concentrations, increased the latency to develop a seizure, decreased the seizure duration and shortened the EEG amplitude. These results suggest that neuronal seizure activity and systemic inflammation are increased in severe PE. In addition, MgSO treatment reduced systemic inflammation and seizure severity. We conclude that excessive systemic inflammation in PE promotes eclampsia seizures, which can be attenuated by MgSO treatment.

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“…Increasing evidence suggests that an exaggerated maternal systemic inflammatory response to pregnancy with an increase in the ratios of peripheral blood Th1/Th2 and Th17/ regulatory T cells, a systemic oxidative stress, as well as an imbalance between circulating angiogenic and anti-angiogenic factors plays a crucial role in the pathogenesis of the disease. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Endocannabinoids are endogenous ligands that bind to the similar receptor as delta-9-tetrahydrocannabinol (Δ 9 -THC), the most potent psychotropic constituent of marijuana. The most studied endocannabinoid is N-arachidonoylethanolamine (also known as anandamide), which is reported to have a central role in female reproduction, particularly in decidualization, 17 oviductal transport, 18 preimplantation embryo development, 19 timely embryo implantation and ensuring receptive uterine environment.…”

Section: Introductionmentioning

confidence: 99%

Decreased circulating anandamide levels in preeclampsia

et al. 2015

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The endocannabinoid system has a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both spontaneous miscarriage and ectopic pregnancy. Anandamide has also been implicated in blood pressure regulation. In this study, we aimed to determine circulating anandamide levels in preeclampsia for the first time in the literature. Forty-three preeclamptic patients and 71 healthy pregnant women were involved in this case-control study. Serum anandamide concentrations were determined by high-performance liquid chromatography-mass spectrometry technique. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were measured by electrochemiluminescence immunoassay. For statistical analyses, nonparametric methods were applied. Serum levels of anandamide were significantly lower in preeclamptic patients than in healthy pregnant women (0.75 (0.44-1.03) ng ml(-1) vs. 1.30 (0.76-2.0) ng ml(-1), P<0.001). Preeclamptic patients had significantly higher sFlt-1 levels (12,121 (7963-18,316) pg ml(-1) vs. 2299 (1393-3179) pg ml(-1), P<0.001) and significantly lower PlGF concentrations (71.2 (39.2-86.4) pg ml(-1) vs. 256.8 (181.1-421.0) pg ml(-1), P<0.001) as compared with healthy pregnant women. Serum anandamide concentrations did not correlate with serum levels of sFlt-1 and PlGF in our healthy pregnant and preeclamptic groups. In conclusion, we demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia. However, the cause and consequence of this observation remain to be determined.

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Combination of plasma-soluble fms-like tyrosine kinase 1 and uterine artery Doppler for the prediction of preeclampsia in cases of elderly gravida

Cited by 15 publications

References 24 publications

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Increased neuronal seizure activity correlates with excessive systemic inflammation in a rat model of severe preeclampsia

Decreased circulating anandamide levels in preeclampsia

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