2009
DOI: 10.1586/era.09.121
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Combination of radiotherapy and chemotherapy in locally advanced NSCLC

Abstract: The combination of radiotherapy and chemotherapy is considered to be a standard approach for patients with locally advanced, stage III non-small-cell lung cancer. The current state of the art of combined radiochemotherapy supported by evidence-based data is presented. As shown in the meta-analyses, the concurrent radiochemotherapy gives a superior outcome in terms of survival compared with sequential delivery of both modalities. This is obtained at the expense of higher toxicity, which makes further intensific… Show more

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Cited by 11 publications
(4 citation statements)
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“…29,30 It is thus likely that more patients with stage III NSCLC seen in contemporary practice would be eligible for radical treatment and that data from more recent years might produce different outcomes compared with those observed in this study. These include a relatively small sample of radically treated patients with stage III NSCLC, reflecting biases in patient and treatment selection inherent in retrospective studies.…”
Section: Discussionmentioning
confidence: 81%
“…29,30 It is thus likely that more patients with stage III NSCLC seen in contemporary practice would be eligible for radical treatment and that data from more recent years might produce different outcomes compared with those observed in this study. These include a relatively small sample of radically treated patients with stage III NSCLC, reflecting biases in patient and treatment selection inherent in retrospective studies.…”
Section: Discussionmentioning
confidence: 81%
“…[313233] However, both treatment methods are associated with a high toxicity. Microwave is a nonionizing radiation and shows less toxicity than chemotherapy and radiotherapy in cancer patients.…”
Section: Discussionmentioning
confidence: 99%
“…Concurrent CT/RT (CT/RT) is the standard treatment for locally advanced and unresectable non-small cell lung cancer (NSCLC). However, it is characterized by a high risk of oesophagitis and dysphagia, as well as other treatment-related toxicities [73][74][75][76]. Oesophagitis and dysphagia may be severe and disabling, resulting in pain, weight loss, hospitalization and the need for a gastrostomy or jejunostomy tube for enteral feeding.…”
Section: Dysphagia In Lung Cancermentioning
confidence: 99%