Combination of t(14;18) and a Burkitt's Type Translocation in B-cell Malignancies

Karsan, Aly; Gascoyne, Randy D.; Coupland, Robert; Shepherd, John; Phillips, Gordon L.; Horsman, Douglas E.

doi:10.3109/10428199309148200

Cited by 70 publications

(59 citation statements)

References 34 publications

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“…44 In addition, a small subset of follicular lymphoma, along with t(14;18)(q32;21), have a Burkitt-type translocation involving 8q24, that is, t(8;14)(q24;q32), t(8;22)(q24;q11), or t(2;8)(q12;q24); these 'double hit' cases are associated with blastic morphology, an aggressive disease course, and short survival. 34, 45 We did not detect MYC translocation, but rather found a loss of one MYC allele in four of our five cases, a feature which distinguishes diffuse blastoid B-cell lymphomas from the above mentioned cases of follicular lymphoma.…”

Section: Diffuse Blastoid B-cell Lymphomacontrasting

confidence: 58%

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

et al. 2009

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Among the diffuse lymphomas of B-cell origin, we have encountered one variant displaying blastoid features that morphologically mimic lymphoblastic lymphoma, the blastoid variant of mantle cell lymphoma, and the so-called blastoid transformation of follicular lymphoma. To better characterize this entity, we studied eight cases morphologically, immunohistochemically, and by fluorescence in situ hybridization (FISH) for cytogenetic abnormalities commonly associated with follicular lymphoma and B-cell lymphomas exhibiting high-grade histological features. All eight cases were presented as de novo neoplasms, and displayed an entirely diffuse (five cases) or only minimal follicular (three cases) growth pattern. The neoplastic lymphoid cells were of medium size with round nuclei, fine chromatin, inconspicuous nucleoli, and high mitotic rate; they expressed CD10, BCL6, and BCL2-a phenotype consistent with follicle center cell origin. A proportion of cases expressed MUM1. Their lack of TdT and CYCLIN D1 distinguished them from lymphoblastic lymphoma and the blastoid mantle cell lymphoma, respectively. The neoplastic lymphoid cells consistently expressed CD43 (seven of eight cases) and occasionally other T-cell-associated antigens, including CD5, CD7, CD8, and CD57. Although all cases overexpressed BCL2, t(14;18) was not detected in any of the five cases examined by FISH; instead, extra copies of chromosome 18 were found in four of five cases. Finally, other cytogenetic abnormalities, including structural abnormalities of BCL6 (allelic loss/gain, rearrangement), monosomy 7, del(13)(q14), and MYC allelic loss, were frequently detected. The combination of a B-cell CD10 þ BCL6 þ BCL2 þ phenotype in the presence of structural abnormalities of BCL6 is consistent with a follicular center cell derivation for our cases. The lack of t(14;18) seen in our cases, although rare in most cases of follicular lymphoma, has been nevertheless reported in cases of follicular lymphoma with a predominantly diffuse growth pattern. The molecular pathogenesis, clinical manifestations, and prognostic significance of these lesions remain to be elucidated.

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Section: Diffuse Blastoid B-cell Lymphomacontrasting

confidence: 58%

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

et al. 2009

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“…The implication of band 8q24 is the rule, found in 20 of the 24 cases. The frequency of variant Burkitt's translocation t (8;22) 8,9,12,14 in this context is noteworthy 9 but this region could also be implicated in t(8;14), 6, 7, 9, 10, 11 in t(8;9)(q24;p13) 13,16 or, as in our patient 1, in complex translocation t(8;14;18)(q24;q32;q21). 15 As in our patient 2, molecular implication of c-MYC could not always be demonstrated, 10,13 especially in translocations not involving immunoglobulin genes.…”

Section: Discussionmentioning

confidence: 88%

“…[6][7][8][9][10][11][12][13][14][15][16][17] Most patients presented with a rapid deterioration of physical conditions with fatigue, fever, night sweat and weight loss. Initial presentation associated massive bone marrow infiltration, nodal and extranodal involvement with frequent soft tissue or bone masses.…”

Section: Discussionmentioning

confidence: 99%

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De novo acute B cell leukemia/lymphoma with t(14;18)

Stamatoullas¹,

Buchonnet

Leprêtre³

et al. 2000

Leukemia

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The t(14;18)(q32;q21) translocation is the most common translocation in B cell malignancies being found in 80% of follicular lymphomas and about 20% of diffuse large B cell lymphomas. Only rare cases of de novo acute B cell lymphoblastic leukemia with t(14;18) have been described. We describe five cases of this entity which appears to have very homogeneous clinical, phenotypic and genotypic features. None of these patients had prior history of follicular lymphoma. The disease was characterized by acute clinical features with nodal and/or extranodal disease, massive bone marrow infiltration and rapid increase of circulating blast cells of mature B cell phenotype. All patients disclosed complex chromosomal and molecular abnormalities involving at least the BCL-2 and c-MYC genes. Furthermore, three patients had evidence of BCL-6 involvement and one patient had a p53 mutation. Despite intensive chemotherapy, including for two patients allogeneic bone marrow transplantation in first complete remission, all patients died within a few months. Neuro-meningeal relapse occurred in three of the five patients in spite of neuro-meningeal prophylaxis. De novo leukemia/lymphoma with t(14;18) is a rare entity with a very poor prognosis. Whether early bone marrow transplant could modify the natural history of the disease remains to be determined. An intensive neuro-meningeal prophylaxis appears to be mandatory in these patients. Leukemia (2000Leukemia ( ) 14, 1960Leukemia ( -1966

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“…There have been 11 case reports of Burkitt-type leukemia (ALL-L3) in the literature with both the t(14;18) and variants of c-MYC (t(8;14) or t(8;22)). [13][14][15][16][17][18] By contrast, concurrent t(2;8) and t(14;18) is very rare and has been reported only once in a cell line created from a patient with chronic lymphocytic leukemia. 19 In this case, an immortalized cell line initially carried t(14;18) without t(2;8).…”

Section: Discussionmentioning

confidence: 99%

Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

et al. 2006

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We identified 14 B-cell neoplasms with concurrent t(14;18) and chromosome 8q24 or c-MYC translocations shown by conventional cytogenetics or fluorescence in situ hybridization analysis. All cases assessed by conventional cytogenetics had a complex karyotype. There were 10 men and four women, with a median age of 55 years (range, 29-72). None of these patients had a history of follicular lymphoma. The biopsy specimens were obtained from bone marrow, lymph node, and extranodal sites. Morphologically, nine neoplasms had features of Burkitt or atypical Burkitt lymphoma/leukemia and three were diffuse large B-cell lymphoma with high-grade cytologic features. The remaining two cases were plasmablastic myeloma and low-grade B-cell lymphoma, respectively. All cases expressed BCL-2. The proliferation index assessed by using Ki-67 (MIB1) was 5% in the low-grade B-cell lymphoma, 80% in the plasmablastic myeloma, 90-95% in three cases of diffuse large B-cell lymphoma, and ranged from 90 to 499% in most Burkitt and atypical Burkitt neoplasms. The patient with low-grade B-cell lymphoma was treated with rituximab. All other patients received intensive combination chemotherapy. Two of these patients underwent bone marrow transplantation, and one patient received radiation therapy in addition to transplantation. The median follow-up period was 9 months (range, 3-81). In all, 10 patients died with a median survival of 9 months (range, 3-81). We conclude that most B-cell lymphomas with concurrent t(14;18) and 8q24/c-MYC translocations fall within the morphologic spectrum of diffuse large B-cell and Burkitt lymphoma. These neoplasms are high-grade and are associated with a poor prognosis. However, this combination of molecular abnormalities can also rarely occur in other neoplasms, such as the cases of low-grade B-cell lymphoma and plasmablastic myeloma in this study.

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Combination of t(14;18) and a Burkitt's Type Translocation in B-cell Malignancies

Cited by 70 publications

References 34 publications

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

De novo acute B cell leukemia/lymphoma with t(14;18)

Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

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