Combination phototherapy of psoriasis with narrow-band UVB irradiation and topical tazarotene gel

Behrens, Stefanie; Grundmann-Kollmann, Marcella; Schiener, R.; Peter, R. U.; Kerscher, Martina

doi:10.1016/s0190-9622(00)90225-1

Cited by 81 publications

(41 citation statements)

References 10 publications

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“…Two more studies investigated the combination of NB-UVB with topical treatments. NB-UVB and tazarotene obtained PASI75 in 10% of the patients [15] and with calcipotriol in 52% (in this study PASI75 is estimated in reference 7) [16] . Only 2 of the studies published in the literature reviewing NB-UVB in psoriasis assessed the size of the plaques [10,17] .…”

Section: Discussionsupporting

confidence: 47%

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Fernández‐Guarino¹,

Aboín-González²,

Velázquez³

et al. 2016

Dermatology

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Background: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). Objective: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. Material and Methods: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment. The follow-up period was 18 months. After treatment, patients completed a simple questionnaire to assess their overall impression of the treatment. Results: The 67 adult patients with AGP included in this study had an initial PASI of 8.55 (SD 5.03). Patients were treated with a mean of 19.9 sessions (SD 13.5) and mean doses of 14 mJ/cm² (SD 10.5). Of the 67 patients, 52 achieved PASI90 with 96.15% of PASI reduction, and of these, 46 (88%) maintained PASI90 during the 18 months of follow-up. Patients were very satisfied with the treatment. Discussion: AGP is a defined clinical entity with a variable course. Phototherapy with NB-UVB appears to be a very good option for treatment of AGP because of the good results obtained and patient satisfaction.

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Section: Discussionsupporting

confidence: 47%

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Fernández‐Guarino¹,

Aboín-González²,

Velázquez³

et al. 2016

Dermatology

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“…[1] Tazarotene has also been combined with various other modalities like NB UVB phototherapy, PUVA therapy and compared with topical calcipotriol in various studies, with results showing greater efficacy with combination treatment. [5–7]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of topical 0.1% tazarotene cream in the treatment of palmoplantar psoriasis: An observer-blinded randomized controlled study

Mehta¹,

Amladi²

2011

Indian J Dermatol

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Background:Palmoplantar psoriasis is a frequently encountered variant of psoriasis. It is difficult to treat and even more difficult to maintain remission as it is exacerbated by friction and trauma of the patient's daily activities. Existing topical modalities of treatment are often inadequate and show unpredictable response.Aim:To study the efficacy and safety of a newer retinoid, tazarotene, as 0.1% cream in the treatment of palmoplantar psoriasis.Materials and Methods:Thirty adult patients with palmo-plantar psoriasis were randomized to therapy with once daily application of topical tazarotene cream (0.1%) or once daily application of clobetasol propionate cream (0.05%) for 12 weeks. The patients were assessed every 2 weeks for improvement in Erythema, Scaling, Fissures and Induration (ESFI) score and Physicians Global Assessment Scale.Results:At 12 weeks, the tazarotene group showed mean ESFI reduction to 1.12 (83.2%) from 6.65 at baseline. Complete clearance was noted in 52.9% of the patients. Clobetasol propionate group showed mean ESFI reduction to 0.62 (89.1%) from 5.69 at baseline, with complete clearance in 61.5% of the patients. Differences between the two groups were statistically insignificant. Side effects observed were initial irritation (41%) in the tazarotene group and hypopigmentation (53.8%) in the steroid-treated patients.Conclusion:Tazarotene is as effective as clobetasol propionate and provides a good alternative for the treatment of palmo-plantar psoriasis where hypopigmentation limits the use of clobetasol propionate cream.

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“…UVB plus topical retinoids: In clinical studies, tazarotene 0.1% gel in combination with nUVB showed faster and significantly greater reduction of psoriasis plaques with significantly lower median cumulative UV exposure than UVB alone (67,68). Mild irritations like erythema, peeling, dryness, burning and pruritus do occur but photosensitivity is not observed (69,70).…”

Section: Psoriasismentioning

confidence: 99%

Phototherapy with Narrowband vs Broadband UVB

Berneburg¹,

Röcken²,

Benedix³

2005

Acta Dermato-Venereologica

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Phototherapy with ultraviolet (UV) radiation of wavelengths between 280 and 320 nm (UVB) is a safe and effective treatment for a variety of diseases. In addition to standard broadband UVB (bUVB), narrowband phototherapy with fluorescent bulbs emitting near monochromatic UV around 311 nm (nUVB) has become an important treatment for diseases such as psoriasis, atopic dermatitis and vitiligo. In addition to these indications, the number of diseases for which nUVB phototherapy is reported to be effective is continuously growing. The differential effects of nUVB phototherapy in comparison to other UV wavelengths as well as established and new indications for this treatment modality are reviewed.

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Combination phototherapy of psoriasis with narrow-band UVB irradiation and topical tazarotene gel

Cited by 81 publications

References 10 publications

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Evaluation of topical 0.1% tazarotene cream in the treatment of palmoplantar psoriasis: An observer-blinded randomized controlled study

Phototherapy with Narrowband vs Broadband UVB

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