Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Fernández‐Guarino, M.; Aboín-González, S.; Velázquez, Diana; Barchino, Lucia; Cano, Natividad Herrera; Lázaro, Pablo

doi:10.1159/000448918

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…While calcipotriol/betamethasone is usually prescribed as a first‐line treatment in mild to moderate psoriasis, NB‐UVB is typically used in more severe cases or in patients who do not respond to topical therapies . Although several studies have been performed to compare various phototherapy modalities, to date no direct comparisons of topical therapies and phototherapy have been carried out . Moreover, only two studies have investigated NB‐UVB used concurrently with topical therapies: one study evaluated NB‐UVB combined with tazarotene, and another investigated NB‐UVB with concurrent calcipotriol …”

Section: Discussionmentioning

confidence: 99%

Calcipotriol/betamethasone ointment compared to narrow‐band UVB in plaque psoriasis: first clinical and ultrasonographic study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Calcipotriol/betamethasone ointment compared to narrow‐band UVB in plaque psoriasis: first clinical and ultrasonographic study

et al. 2018

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“…[154][155][156] Studies have also shown that narrow-band UVB is more effective than broad-band UVB (wavelength 290-320 nm). [157][158][159][160][161] As such, narrow-band UVB is the preferred phototherapy for guttate psoriasis in children over 6 years of age. [157][158][159][160][161] Psoralen plus UVA (wavelength 320-400 nm) (PUVA) phototherapy has also been used for the treatment of guttate psoriasis.…”

Section: Tazarotenementioning

confidence: 99%

“…[157][158][159][160][161] As such, narrow-band UVB is the preferred phototherapy for guttate psoriasis in children over 6 years of age. [157][158][159][160][161] Psoralen plus UVA (wavelength 320-400 nm) (PUVA) phototherapy has also been used for the treatment of guttate psoriasis. 162 In one randomized double-blind trial involving 88 patients with plaque psoriasis, 43 patients were treated with PUVA and 45 with narrow-band UVB.…”

Section: Tazarotenementioning

confidence: 99%

Childhood guttate psoriasis: an updated review

Leung,

Barankin,

Lam

et al. 2023

DIC

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Background Guttate psoriasis is common and affects 0.5–2% of individuals in the paediatric age group. This review aims to familiarize physicians with the clinical manifestations, evaluation, diagnosis and proper management of guttate psoriasis. Methods A search was conducted in July 2023 in PubMed Clinical Queries using the key term “guttate psoriasis”. The search strategy included all observational studies, clinical trials and reviews published within the past 10 years. The information retrieved from the search was used in the compilation of the present article. Results Guttate psoriasis typically presents with an abrupt onset of numerous, small, scattered, tear-drop-shaped, scaly, erythematous, pruritic papules and plaques. Sites of predilection include the trunk and proximal extremities. There may be a history of preceding streptococcal infection. Koebner phenomenon is characteristic. Guttate psoriasis may spontaneously remit within 3–4 months with no residual scarring, may intermittently recur and, in 40–50% of cases, may persist and progress to chronic plaque psoriasis. Given the possibility for spontaneous remission within several months, active treatment may not be necessary except for cosmetic purposes or because of pruritus. On the other hand, given the high rates of persistence of guttate psoriasis and progression to chronic plaque psoriasis, some authors suggest active treatment of this condition. Conclusion Various treatment options are available for guttate psoriasis. Triggering and exacerbating factors should be avoided if possible. Topical corticosteroids alone or in combination with other topical agents (e.g. tazarotene and vitamin D analogues) are the most rapid and efficient treatment for guttate psoriasis and are therefore the first-line treatment for mild cases. Other topical therapies include vitamin D analogues, calcineurin inhibitors, anthralin, coal tar and tazarotene. Ultraviolet phototherapy is the first-line therapy for moderate-to-severe guttate psoriasis, as it is more practical than topical therapy when treating widespread or numerous small lesions. Systemic immunosuppressive and immunomodulatory therapies (e.g. methotrexate, cyclosporine, retinoids, fumaric acid esters and biologics) may be considered for patients with moderate-to-severe guttate psoriasis who fail to respond to phototherapy and topical therapies.

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“…Furthermore, the use of MTX is contraindicated for pregnant and breastfeeding women [16]. Other therapeutic agents for psoriasis are narrowband ultraviolet B [17] and certain biologic agents [18]. However, these agents are not widely available and are relatively expensive, necessitating the development of new, safer, and more affordable anti-psoriasis agents with anti-inflammatory and proapoptotic effects.…”

Section: Introductionmentioning

confidence: 99%

Indonesian Ciplukan Extract Inhibited TGF-β1/NF-κB Pathway in Experimental Psoriasis Mouse Models

Sylviningrum

Wasita

Purwanto

et al. 2022

Open Access Maced J Med Sci

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Background:The global prevalence of psoriasis, a chronic inflammatory skin disease, has substantially increased in the last decade. The increase activity of Transforming Growth Factor ß1 (TGFß1)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway which cause inflammation, is the major pathological mechanism in psoriasis. Current psoriasis treatment using chemical agents is hampered by the side-effects when used long-term, which underlines the need for alternative, low side-effect anti-psoriatic agents. The extract of Physalis angulata L., also known as Ciplukan in Indonesia, contains Physalins, compounds known for their anti-inflammatory effects, but whose effect on psoriasis has not been studied. Objective: This study aimed to investigate the effect of Ciplukan extract (CE) to TGFß1/NF-κB pathway in psoriasis mouse models. Methods: This was experimental study with posttest-only control group design. The CE active ingredients were identified using Liquid chromatography-tandem mass spectrometry (LC-MS/MS). Twenty-five female imiquimod (IMQ) induced psoriasis-like dermatitis mice were allocated into five groups, with three groups receiving 7 days of 400, 800, and 1200 mg/kg bodyweight doses of CE, respectively, and two groups serving as control and IMQ groups. The NF-κB and TGFß1 expressions were evaluated using Allred score based on immunohistochemistry (IHC) staining. Histopathology and clinical psoriasis manifestations were assessed using Baker’s from Hematoxylin Eosin (HE) staining and Psoriasis Area Severity Index (PASI) scores. The Kruskal-Wallis followed by Mann Whitney tests were conducted for data analysis. The p-value < 0.05 was considered to be statistically different. Results: Based on LC-MS/MS test, Physalin B, D, and F were active ingredients from CE in ethyl acetate solution. An improvement in psoriasis inflammation was observed in 400 and 800 mg/kg bodyweight doses of CE, but only the dosage of 800 mg/kg BW significantly decreased of Allred scores from NF-κB and TGFß1 expressions; Baker’s and PASI scores compared to IMQ group (p<0.05). The 1200 mg/kg bodyweight doses of CE associated with acute toxicity signs and mortality, meanwhile dosage of 800 mg/kg BW showed the highest efficacy with lowest toxicity effect. Conclusions: Ciplukan extract improved psoriasis manifestations via inhibition effect to TGFß1/NF-κB pathway and the extract might be developed as an alternative anti-psoriasis agent

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Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Cited by 9 publications

References 25 publications

Calcipotriol/betamethasone ointment compared to narrow‐band UVB in plaque psoriasis: first clinical and ultrasonographic study

Calcipotriol/betamethasone ointment compared to narrow‐band UVB in plaque psoriasis: first clinical and ultrasonographic study

Childhood guttate psoriasis: an updated review

Indonesian Ciplukan Extract Inhibited TGF-β1/NF-κB Pathway in Experimental Psoriasis Mouse Models

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