2015
DOI: 10.1016/j.jvir.2014.09.002
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Combination Radiofrequency Ablation and Local Injection of the Immunostimulant Bacillus Calmette–Guérin Induces Antitumor Immunity in the Lung and at a Distant VX2 Tumor in a Rabbit Model

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Cited by 10 publications
(12 citation statements)
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“…Whether the different energy sources can have varied effects beyond the ablation margin has so far remained an open question. Nevertheless, this issue is becoming ever more important as we become aware of potential systemic effects of what have previously been considered focal ablative treatments (6)(7)(8)(9)(10). Indeed, local hepatic or tumor RF ablation can stimulate proinflammatory factors, including the following: interleukin 6 (IL-6), which activates the NF-kB signaling pathway; the c-Met pathway; and both hypoxia-inducible factor 1a and vascular endothelial growth factor upregulation, which can lead to increased angiogenesis and subsequent tumorigenesis (11)(12)(13)(14)(15)(16).…”
Section: Mice and Ablation Protocolmentioning
confidence: 99%
“…Whether the different energy sources can have varied effects beyond the ablation margin has so far remained an open question. Nevertheless, this issue is becoming ever more important as we become aware of potential systemic effects of what have previously been considered focal ablative treatments (6)(7)(8)(9)(10). Indeed, local hepatic or tumor RF ablation can stimulate proinflammatory factors, including the following: interleukin 6 (IL-6), which activates the NF-kB signaling pathway; the c-Met pathway; and both hypoxia-inducible factor 1a and vascular endothelial growth factor upregulation, which can lead to increased angiogenesis and subsequent tumorigenesis (11)(12)(13)(14)(15)(16).…”
Section: Mice and Ablation Protocolmentioning
confidence: 99%
“…VX2 tumors previously implanted and maintained in the thigh muscles of rabbits were surgically removed with the animals under general anesthesia and in experimental models for its potential to induce antitumor immunity after RFA (15,16). Recently, anticancer drugs have been combined with RFA in clinical settings, although the number of reports is limited.…”
Section: Experimental Modelmentioning
confidence: 99%
“…The success of the procedure, however, is dependent on tumor size because of the small ablation zone obtainable with currently available electrode needles (6-8). Various experimental studies have investigated strategies to improve local control rates for lung tumors (9)(10)(11)(12)(13)(14)(15)(16)(17). For example, RFA has been combined with balloon occlusion of the pulmonary artery (9), intraparenchymal saline injection (10,11), pulmonary arterial embolization, and segmental pulmonary artery chemoembolization in an attempt to extend the coagulation zone (12)(13)(14).…”
Section: Author Contributionsmentioning
confidence: 99%
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