Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome

Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies

“…Fecal microbiota transpant is the transportation of gut microbiota from healthy donors’ feces into patients’ small intestines through oral or rectal routes [ 167 ]. In light of the hypothesis that gut dysbiosis contributes to PCOS symptoms, treatment with an FMT derived from healthy donors or representative microbes from a healthy gut is expected to be a helpful to re-diversify the gut microbiome [ 9 ]. Performing an FMT from healthy rats into a letrozole-induced PCOS rat model led to a reduction in androgen levels, better estrous cycles, improved ovarian shape, higher levels of Lactobacillus , and Clostridium species, and a decline in Prevotella species, according to one study conducted [ 50 ].…”

“…Over 30 such gut hormones have now been identified. This suggests that eating behavior and GI motility are collaboratively regulated by gut hormone production [ 9 , 10 ]. It is also reported that gram-negative bacteria cause inflammation in the gut due to the production of lipopolysaccharide [ 11 ].…”

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

“…Moreover, some lactic acid bacterial strains can also alleviate steroidogenesis dysbiosis in patients with PCOS by modifying the population of sex hormone-related gut microbiota, ultimately regulating FSH, luteinizing hormone, and testosterone levels [99] . Recently, FMT showed considerable effectiveness in PCOS with much lower rates of remission by reestablishing gut eubiosis after gut dysbiosis [100] , suggesting the beneficial effect of bacteria with probiotic roles in PCOS.…”

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

“…Many functions of probiotics, including protecting the gut barrier, improving IR and regulating the immune system, have been revealed [130]. Studies in Iran revealed that a 12-week probiotics supplementation (Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum) can bring good metabolic effect to PCOS [131,132]. Other RCTs in Iran used a 8-week probiotics treatment, including Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium longum and Streptococcus thermophiles, which also showed Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and fasting plasma glucose (FPS) are improved [133].…”