Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria

Sulthana, Shoukath; Banerjee, Tuhina; Kallu, Jyothi; Vuppala, Sudershini Reddy; Heckert, Blaze; Naz, Shuguftha; Shelby, Tyler; Yambem, Olivia; Santra, Santimukul

doi:10.1021/acs.molpharmaceut.6b01076

Cited by 47 publications

(26 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In clinics, chemotherapy for cancer patients is commonly based on the drug indications, recommended dosages, treatment duration, and adverse effects (e.g., nephrotoxicity and hepatotoxicity; Grossi et al, ; Sharbaf, Farhangi, & Assadi, ; Sulthana et al, ). Occasionally, it is difficult to prevent occurrences of adverse effects from chemotherapeutic drugs during therapy.…”

Section: Introductionmentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

287

175

View full text Add to dashboard Cite

Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

Section: Introductionmentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

287

175

View full text Add to dashboard Cite

show abstract

“… Cerium nitrate hexahydrate and potassium carbonate Water Co-precipitation method [ 32 ] 16. Cerium nitrate hexahydrate, polyacrylic acid, and ammonium hydroxide Water Precipitation method [ 33 ] 17. Cerium nitrate hexahydrate and ammonium hydroxide Water Precipitation method [ 34 ] 18.…”

Section: Synthesis Of Nanoceriamentioning

confidence: 99%

Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

2019

View full text Add to dashboard Cite

Background Nanoceria has recently received much attention, because of its widespread biomedical applications, including antibacterial, antioxidant and anticancer activity, drug/gene delivery systems, anti-diabetic property, and tissue engineering. Main body Nanoceria exhibits excellent antibacterial activity against both Gram-positive and Gram-negative bacteria via the generation of reactive oxygen species (ROS). In healthy cells, it acts as an antioxidant by scavenging ROS (at physiological pH). Thus, it protects them, while in cancer cells (under low pH environment) it acts as pro-oxidant by generating ROS and kills them. Nanoceria has also been effectively used as a carrier for targeted drug and gene delivery in vitro and in vivo models. Besides, nanoceria can also act as an antidiabetic agent and confer protection towards diabetes-associated organ pathophysiology via decreasing the ROS level in diabetic subjects. Nanoceria also possesses excellent potential in the field of tissue engineering. In this review, firstly, we have discussed the different methods used for the synthesis of nanoceria as these are very important to control the size, shape and Ce 3+ /Ce 4+ ratio of the particles upon which the physical, chemical, and biological properties depend. Secondly, we have extensively reviewed the different biomedical applications of nanoceria with probable mechanisms based on the literature reports. Conclusion The outcome of this review will improve the understanding about the different synthetic procedures and biomedical applications of nanoceria, which should, in turn, lead to the design of novel clinical interventions associated with various health disorders. Graphical abstract

show abstract

“…Consistent with its dual effect on ROS in normal vs. cancer tissues, CeO-NPs enhanced the anticancer effects of doxorubicin while significantly reducing the undesired side effects of this compound on normal cells, including myocardiocytes. This is a significant finding, given the relevance of myocardiotoxicity of doxorubicin in cancer patients [22]. In a recent study, Hijaz et al combined CeO-NPs with folic acid to target ovarian cancer cells that overexpress a membrane-bound isoform of folate receptor with cisplatin, which exerts its anticancer activity partly by enhancing ROS levels [11]; results showed a significant anticancer effect both in vitro and in a xenograft mouse model [23].…”

Section: Modulation Of Redox Homeostasis By Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

et al. 2020

View full text Add to dashboard Cite

Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are strongly addicted to the increased activity of scavenging pathways to maintain ROS below levels that produce macromolecular damage and engage cell death pathways. Consistent with this notion, tumor cells are more vulnerable than their normal counterparts to pharmacological treatments that increase ROS production and inhibit ROS scavenging. In the present review, we discuss the recent advances in the development of integrated anticancer therapies based on nanoparticles engineered to kill cancer cells by raising their ROS setpoint. We also examine nanoparticles engineered to exploit the metabolic and redox alterations of cancer cells to promote site-specific drug delivery to cancer cells, thus maximizing anticancer efficacy while minimizing undesired side effects on normal tissues.

show abstract

Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria

Cited by 47 publications

References 38 publications

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Contact Info

Product

Resources

About