Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis

The diagnosis and management of rhinitis: An updated practice parameter

“…46 Combination therapy with intranasal corticosteroids may provide added benefit. 339 The only intranasal antihistamines currently available in the United States, azelastine, [332][333][334][335][336][337][338] and olopatadine, 340 have a rapid onset of action. 341 Bitter taste has been reported with both preparations, and sedation may occur 342 (Table VII).…”

Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis

“…Thus, clinicians have given additional treatments to improve the efficacy of intranasal steroids. 2 Although the effects of intranasal steroids can be seen as early as 12 hours after administration, their maximum efficacy takes days. This delay in the onset of action prevents instant recognition of the effectiveness of the intranasal steroid.…”

Update on local allergic rhinitis

“…Combination therapy with intranasal corticosteroids may provide added benefit [53]. Azelastine and olopatadine are approved for the treatment of seasonal AR.…”