Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis

A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion

“…Although AcR is not a typical outcome measurement in SAR clinical trials, it has been demonstrated that AcR is a reliable technique to objectively assess nasal congestion; in a previous study AcR was able to confirm the expected greater clinical benefit of the combination of oxymetazoline and fluticasone compared with oxymetazoline alone. 24 In the present study there was a significantly smaller decrease in nasal patency in the EEC with pseudoephedrine (active comparator) compared with placebo, which is similar to an earlier study 25 ; it thus proved itself as a good control and comparator for this study. However, in the PF-03654746 study contradictory findings were observed; the expected reduction of nasal patency by using AcR was not detected for the pseudoephedrine and fexofenadine combination, 19 a finding that the authors suggested might reflect variability inherent in the AcR method and that also might be due to differences in the method of AcR collection and analysis compared with those used in our study.…”

Advances in upper airway diseases and allergen immunotherapy in 2011

“…In a double-blind, placebo-controlled (DBPC), 4-arm, parallel-group randomized clinical trial involving 60 subjects with perennial allergic rhinitis, combined treatment with the intranasal corticosteroid fluticasone plus the decongestant oxymetazoline was more beneficial than single therapy with either alone. 7 Combination therapy significantly improved nasal symptoms and nasal patency measured with acoustic rhinometry. Importantly, there was no rhinitis medicamentosa with decongestant alone or with combination therapy.…”

“…We start with the key advances in upper airway diseases, which are summarized in Table I. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] …”

Update on Clinical Options for the Management of Allergic Rhinitis

“…101 Another trial recently showed the combination of oxymetazoline and fluticasone furoate to be more effective than either agent alone in improving symptoms scores in patients with perennial allergic rhinitis. 102 Interestingly there was no evidence of rhinitis medicamentosa at the end of the 4 week trial.…”