Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators

Jhun, JooYeon; Min, Hong-Ghi; Na, Hyun Sik; Kwon, Ji Ye; Ryu, Jaeyoon; Cho, Keun-Hyung; Choi, Jung-Hwa; Jung, Kyoung-Sim; Lee, Seon‐Yeong; Kim, Seok Jung; Yang, Chul Woo; Park, Sung-Hwan; Cho, Mi‐La

doi:10.1016/j.imlet.2020.10.008

Cited by 20 publications

(24 citation statements)

References 37 publications

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“…Moreover, in an animal model of OA, this combination reduced the expression of the catabolic matrix metalloproteinase-13 (MMP-13) and pro-inflammatory cytokines as well as upregulated anabolic tissue inhibitors of metalloproteinases (TIMPs), resulting in the decreased pain, the preservation of cartilage, the inhibition of osteoclastogenesis, and the regulation of anabolic/catabolic imbalance. Therefore, it seems that L. acidophilus, vitamin B, and curcumin have therapeutic potential in patients with OA [82]. However, we failed to find any study of therapeutic effect of curcumin in CKD patients with OA or RA.…”

Section: Human Studiesmentioning

confidence: 81%

“…In CKD and HD patients, curcumin acts as a scavenger of free radicals, which results in a significant suppression of oxidative stress [81]. Due to the fact that curcumin has strong anti-inflammatory and pro-apoptotic properties, it has been tested for its potential utility in the treatment of osteoarthritis (OA) and rheumatoid arthritis (RA), which are diseases associated with degenerative changes in the joint, loss of its function, pain, and severe disability [82,83]. Excessive production and release of pro-inflammatory interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) are observed in the course of OA [84].…”

Section: Human Studiesmentioning

confidence: 99%

“…Wang et al [90] who examined the thesis that HA/chitosan nanoparticles (CNP) improved the efficiency of delivered curcuminoid observed that such composition stimulated the expression of IκB as well as promoted collagen II expression [90]. In vitro study of human peripheral blood mononuclear cells demonstrated that the combination of L. acidophilus, vitamin B, and curcumin efficiently downregulated Th17 cells and the related cytokine IL-17, which led to the enhanced expression of Treg-related cytokine IL-10 [82]. Moreover, in an animal model of OA, this combination reduced the expression of the catabolic matrix metalloproteinase-13 (MMP-13) and pro-inflammatory cytokines as well as upregulated anabolic tissue inhibitors of metalloproteinases (TIMPs), resulting in the decreased pain, the preservation of cartilage, the inhibition of osteoclastogenesis, and the regulation of anabolic/catabolic imbalance.…”

Section: Human Studiesmentioning

confidence: 99%

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Are Nutraceuticals Beneficial in Chronic Kidney Disease?

et al. 2021

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Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.

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Section: Human Studiesmentioning

confidence: 81%

Section: Human Studiesmentioning

confidence: 99%

Section: Human Studiesmentioning

confidence: 99%

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Are Nutraceuticals Beneficial in Chronic Kidney Disease?

et al. 2021

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“…CUR had shown activity against many inflammatory diseases, such as arthritis [17] and inflammatory bowel disease [18]. However, the poor water solubility of CUR limits its physiological effects and current research has suggested many possible ways to rationalize its efficacy [19,20].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties

Gao

Liu

et al. 2021

Molecules

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In this study, we compared the characteristics and in vitro anti-inflammatory effects of two curcumin liposomes, prepared with golden pompano head phospholipids (GPL) and soybean lecithin (SPC). GPL liposomes (GPL-lipo) and SPC liposomes (SPC-lipo) loaded with curcumin (CUR) were prepared by thin film extrusion, and the differences in particle size, ζ-potential, morphology, and storage stability were investigated. The results show that GPL-lipo and SPC-lipo were monolayer liposomes with a relatively small particle size and excellent encapsulation rates. However, GPL-lipo displayed a larger negative ζ-potential and better storage stability compared to SPC-lipo. Subsequently, the effects of phospholipids in regulating the inflammatory response of macrophages were evaluated in vitro, based on the synergistic effect with CUR. The results showed that both GPL and SPC exerted excellent synergistic effect with CUR in inhibiting the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory genes (tumor necrosis factor (TNF)-α, interleukin 1β (IL-β), and interleukin 6 (IL-6)) in RAW264.7 cells. Interestingly, GPL-lipo displayed superior inhibitory effects, compared to SPC-lipo. The findings provide a new innovative bioactive carrier for development of stable CUR liposomes with good functional properties.

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“…Therefore, the choice of bacteria should be carefully considered at the species level. Ultimately, LA, a probiotic consistently reported to have Treg-inducing effects in animal models, was used as a complementary factor for Tac [29,37,40,50,51]. Peterson et al previously reported that LA could promote Treg activity in a mouse model of colitis [29].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Acidophilus Supplementation Exerts A Synergistic Effect on Tacrolimus Efficacy by Restoring Th17/Treg Imbalance in Lupus-Prone Mice via the SIGNR3 Pathway

Kim¹,

Park²,

Choi³

et al. 2020

Preprint

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Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by tissue-binding autoantibodies and immune complexes. Tacrolimus (Tac), also known as FK506, is an immunosuppressant used in the treatment of lupus; however, it induces T-cell imbalances. Lactobacillus acidophilus (LA) is reported to have therapeutic efficacy in immune-mediated diseases via T-cell regulation. This study investigated whether a combination therapy of LA and Tac improves the therapeutic efficacy of Tac by ameliorating T-cell imbalance in an animal model of SLE. Eight-week-old MRL/Mp-Faslpr (MRL/lpr) mice were orally administered with 5 mg/kg of Tac and/or 50 mg/kg of LA daily for 8 weeks. Caecal microbiota compositions, serum autoantibodies levels, the degree of proteinuria, histological changes in the kidney, and populations of various T-cell subsets in the spleen were analysed. Results: MRL/lpr mice presented with significant gut microbiota imbalances, which were subsequently recovered by the combination treatment of Tac and LA. Double negative T-cells, a pathogenic subset of T-cells, in the peripheral blood and spleens of MRL/lpr mice were significantly decreased by the combination therapy. The combination treatment also reduced serum levels of anti-double-stranded DNA antibodies and immunoglobulin G2a, and renal pathology scores were markedly alleviated. The combination therapy induced Treg cells and decreased Th17 cells both in vitro and in vivo. In vitro treatment with LA induced the production of indoleamine-2,3-dioxygenase, programmed death-ligand 1, and inerleukin-10, which was partially mediated by the induction of the specific intracellular adhesion molecule-3 grabbing non-integrin homolog-related 3 (SIGNR3) receptor. Conclusions: The present findings indicate that LA augments the therapeutic effect of Tac and restores Th17/Treg balance in a murine model of lupus. Accordingly, the combination treatment of Tac with LA could be a promising therapeutic candidate for lupus.

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Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators

Cited by 20 publications

References 37 publications

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties

Lactobacillus Acidophilus Supplementation Exerts A Synergistic Effect on Tacrolimus Efficacy by Restoring Th17/Treg Imbalance in Lupus-Prone Mice via the SIGNR3 Pathway

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