Combinatorial Chemistry

Tiebes, Dominika

doi:10.1002/9783527613502.ch01

Cited by 5 publications

(6 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, catalytic asymmetric umpolung reactions via Breslow intermediates have been well-developed for accessing highly valued chiral 1,4-dicarbonyl compounds. [15] However,r elated umpolung transformations utilizing open-shell acyl radicals are still underdeveloped. [16] Until very recently,M elchiorre [16e] and Yu [16f] disclosed two ground-breaking work in which amine-catalyzed asymmetric additions to enals by acyl radicals were accomplished independently by combining with direct photoexcitation and photoredox catalysis.E ncouraged by our above success,w e planned to apply the same DCo5 complex to the visible-lightinduced asymmetric conjugated addition of enones by acyl radicals in the absence of additional photocatalyst.…”

Section: Angewandte Chemiementioning

confidence: 99%

Exploration of a Chiral Cobalt Catalyst for Visible‐Light‐Induced Enantioselective Radical Conjugate Addition

Zhang

Jia

et al. 2019

Angewandte Chemie

View full text Add to dashboard Cite

Chiral catalysts tolerating photochemical reactions are in great demand for the vast development of visible-lightinduced asymmetric synthesis.N ow,c hiral octahedral complexes based on earth-abundant metal and chiral N 4 ligands are reported. One well-defined chiral Co II -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals,p roviding synthetically valued chiral ketones and 1,4-dicarbonyls in 47-> 99 %yields with up to 97:3 e.r.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

show abstract

Section: Angewandte Chemiementioning

confidence: 99%

Exploration of a Chiral Cobalt Catalyst for Visible‐Light‐Induced Enantioselective Radical Conjugate Addition

Zhang

Jia

et al. 2019

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

“…The synthesis of candidate compounds by combining small sets of reagents (building blocks) has become a standard tool in drug discovery . Molecular weight and calculated logP are often used to guide computational combinatorial library design, with some justification. , The additive or iterative use of such descriptors for weeding out unsuitable building blocks has been demonstrated in rapid methods such as GLARE in the library design process .…”

Section: Introductionmentioning

confidence: 99%

Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library Synthesis

Kalliokoski

2015

ACS Comb. Sci.

View full text Add to dashboard Cite

Combinatorial libraries are synthesized by combining smaller reagents (building blocks), the price of which is an important component of the total costs associated with the synthetic exercise. A significant portion of commercially available reagents are too expensive for large scale work. In this study, 13 commonly used reagent classes in combinatorial library synthesis (primary and secondary amines, carboxylic acids, alcohols, ketones, aldehydes, boronic acids, acyl halides, sulfonyl chlorides, isocyanates, isothiocyanates, azides and chloroformates) were analyzed with respect to the cost, physicochemical properties (molecular weight and calculated logP), chemical diversity, and 3D-likeness using a large data set. The results define the chemical space accessible under a constraint of limited financial resources.

show abstract

“…These are compounds that are formulated in a systematic manner, often from the same set of starting materials (Tiebes 1999). The goal is to build up a large library of similar molecules for testing as potential active pharmaceuticals.…”

Section: High Throughput 'System Discovery' Techniquesmentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

274

185

View full text Add to dashboard Cite

Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

show abstract

Combinatorial Chemistry

Cited by 5 publications

References 135 publications

Exploration of a Chiral Cobalt Catalyst for Visible‐Light‐Induced Enantioselective Radical Conjugate Addition

Exploration of a Chiral Cobalt Catalyst for Visible‐Light‐Induced Enantioselective Radical Conjugate Addition

Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library Synthesis

Inkjet printing for pharmaceutics – A review of research and manufacturing

Contact Info

Product

Resources

About