2020
DOI: 10.21873/anticanres.14687
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Combinatorial Cytotoxic Effects of 2,3-Dichloro-5,8-dimethoxy-1,4-naphthoquinone and 4-hydroxytamoxifen in Triple-negative Breast Cancer Cell Lines

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Cited by 7 publications
(4 citation statements)
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“…We tested six quinone derivatives (one 1,4-benzoquinone and five 1,4-NQ derivatives) that have pharmacological effects. These derivatives were hydroquinone (depigmenting agent) (30), 1,4-NQ (anti-cancer agent) (31), DHNA (anti-inflammation agent, bifidogenic growth stimulator) (2224), menadione (vitamin K precursor) (32), juglone (herbicide) (33), and DCDMQ (anti-cancer agent) (34). With the assumption that Ndh2 may play a role in quinone recognition, we injected the six quinone derivatives individually to either the Δ dmkA Δ ndh1 or the Δ dmkA Δ ndh1/2 strains and monitored the differential current density produced by these two mutants.…”
Section: Resultsmentioning
confidence: 99%
“…We tested six quinone derivatives (one 1,4-benzoquinone and five 1,4-NQ derivatives) that have pharmacological effects. These derivatives were hydroquinone (depigmenting agent) (30), 1,4-NQ (anti-cancer agent) (31), DHNA (anti-inflammation agent, bifidogenic growth stimulator) (2224), menadione (vitamin K precursor) (32), juglone (herbicide) (33), and DCDMQ (anti-cancer agent) (34). With the assumption that Ndh2 may play a role in quinone recognition, we injected the six quinone derivatives individually to either the Δ dmkA Δ ndh1 or the Δ dmkA Δ ndh1/2 strains and monitored the differential current density produced by these two mutants.…”
Section: Resultsmentioning
confidence: 99%
“…In such context, the use of computational tools as SynergyFinder and Combenefit may be applied to investigate the degree of a combination effect, easily visible as a synergy landscape map over the dose matrix. So far, these tools were used in in vitro screening studies, to highlight novel synergistic drug combinations in pre-clinical models (e.g., cell lines or primary cells derived from patients), and to better understand the mechanisms of efficacy or resistance of combined treatments [ 27 , 32 ]. In the present paper, for the first time, computational tools were applied to analyze the combined effect of mixtures of chemicals commonly present in food and environment; in addition, the study shows other aspects of novelty: (a) the relevance of results for risk assessment in children since the dose levels of BPA and DEHP have been selected starting from the real exposure scenario in Italian population; (b) the evaluation of chemical mixtures in an in vivo model, according to sex, and (c) data management using cutting-edge tools.…”
Section: Discussionmentioning
confidence: 99%
“…Fluconazole and surfactin interactions were further analyzed using the Bliss independence model with help of the open access Synergyfinder ® application. Briefly, in this software, the Bliss independence model compares the observed versus predicted inhibition response, where a mean synergy score of less than -10 is considered antagonistic, between -10 and 10 is considered to be indifferent and above 10 is synergistic (30).…”
Section: Interactions Between Fluconazole and Surfactin In Vitromentioning
confidence: 99%