Combined 18F-FDG-PET/CT Imaging in Radiotherapy Target Delineation for Head-and-Neck Cancer

Guido, A.; Fuccio, Lorenzo; Rombi, Barbara; Castellucci, Paolo; Cecconi, Agnese; Bunkheila, Feisal; Fuccio, Chiara; Spezi, Emiliano; Angelini, Anna; Barbieri, Enza

doi:10.1016/j.ijrobp.2008.04.059

Cited by 90 publications

(37 citation statements)

References 19 publications

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“…This is in concordance with literature, reporting a PET/CT-based change in patient management in 6-31% (Table 5) [15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Overallsupporting

confidence: 91%

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Influence of FDG-PET on primary nodal target volume definition for head and neck carcinomas

et al. 2016

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“…This is in concordance with literature, reporting a PET/CT-based change in patient management in 6-31% (Table 5) [15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Overallsupporting

confidence: 91%

“…Several studies have reported how FDG-PET/CT led to a change in patient management in 6-57% of the cases [15][16][17][18][19][20][21][22][23][24][25][26][27]. This included upstaging, downstaging as well as diagnosing synchronic lesions and distant metastasis.…”

Section: -[ 18 F]-fluoro-2-deoxy-d-glucose (Fdg)-positron Emissionmentioning

confidence: 99%

Influence of FDG-PET on primary nodal target volume definition for head and neck carcinomas

et al. 2016

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“…In this study it was observed that nodal stage was increased in 5 cases and decreased in 1 case with PET/ CT. Furthermore; new nodal activity was observed in 9 cases without changing the stage even these lymph nodes were not observed with CT imaging (Guido et al, 2009). In our study T stage was increased in 8 cases, decreased in 8 cases and was not changed in 21 cases ; N stage increased in 10 cases, decreased in 2 cases and was not changed in 25 cases with PET/CT.…”

Section: Discussionmentioning

confidence: 99%

Role of PET/CT in Treatment Planning for Head and Neck Cancer Patients Undergoing Definitive Radiotherapy

Arslan¹,

Abakay²,

Şen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…This method is commonly used (13)(14)(15)(16)(17) but is influenced by the display windowing and is dependent on operators. Therefore, several objective methods for contouring PET images have been Katoh 14 developed, including isocontouring based on a fixed threshold of a standardized uptake value (1,(17)(18)(19)(20), a fixed threshold of 40% to 50% of the maximum activity (3,17,(20)(21)(22), and a threshold adapted to the signal-to-background ratios (2,12,17). However, the appropriate standardized technique for the segmentation of PET images is still under investigation in the head and neck region (4)(5)(6)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma

Katoh

Yasuda

Shiga

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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SUMMARYTwo treatment planning methods for nasopharyngeal carcinoma (NPC) were compared: conventional whole-body BGO scintillator positron emission tomography (PET) (PET CONV WB) and a new brain PET system using semiconductor detectors (PET NEW BR). In this study, 12 patients with NPC were analyzed. The gross tumor volume (GTV) was visually delineated on PET images using either PET CONV WB or PET NEW BR. The average absolute volume of GTV contoured with the use of the new brain PET was significantly smaller than that of conventional whole-body BGO PET.Assuming a stereotactic radiotherapy boost plan of 7 ports, the plan using the new brain PET would significantly reduce the maximum dose to the cerebrum and cerebellum and brain stem. The new brain PET system using semiconductor detectors can provide more accurate tumor delineation than the conventional whole-body BGO PET system and has the potential to offer functional and molecular radiotherapy treatment planning.Katoh 4 ABSTRACT Purpose: We compared treatment planning of stereotactic boost for nasopharyngeal carcinoma (NPC) between using conventional whole-body BGO scintillator positron emission tomography (PET) (PET CONV WB) and using the new brain PET system using semiconductor detectors (PET NEW BR).Methods and Materials: The present study included 12 patients with NPC.18 F-fluorodeoxyglucose-PET images were acquired with both the PET NEW BR and a PET CONV WB on the same day. CT and two PET data sets were transferred to a treatment planning system, and the PET CONV WB and PET NEW BR images were co-registered with the same set of CT images. The window width and level for all PET images were fixed at 3000 and 300 respectively. The gross tumor volume (GTV) was visually delineated on PET images using either PET CONV WB images (GTV CONV ) or PET NEW BR images (GTV NEW ). Assuming a stereotactic radiotherapy boost of 7 ports, the prescribed dose delivered to 95% of the planning target volume (PTV) was set to 2000 cGy in 4 fractions.Results: The average absolute volume of GTV NEW was 15.7 ml (standard deviation; SD, 9.9), and that of GTV CONV was 34.0 ml (SD, 20.5). The average of GTV NEW was significantly smaller than that of GTV CONV (p=0.0006). There was no statistically Conclusion: The present study suggests that the new brain PET system using semiconductor detectors can provide more accurate tumor delineation than conventional whole-body BGO PET system and may be an important tool for functional and molecular radiotherapy treatment planning.

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Combined 18F-FDG-PET/CT Imaging in Radiotherapy Target Delineation for Head-and-Neck Cancer

Cited by 90 publications

References 19 publications

Influence of FDG-PET on primary nodal target volume definition for head and neck carcinomas

Influence of FDG-PET on primary nodal target volume definition for head and neck carcinomas

Role of PET/CT in Treatment Planning for Head and Neck Cancer Patients Undergoing Definitive Radiotherapy

A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma

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