Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation

Okazaki, Ryohei; Namba, Hiroyoshi; Yoshida, Hiroyuki; Okai, Hisashi; Taguchi, Kazuki; Kawamura, Minoru

doi:10.1016/j.lfs.2012.12.009

Cited by 13 publications

(9 citation statements)

References 22 publications

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“…Neurotropin, a small nonprotein substance with pharmacologic activities, is extracted and then purified from the inflamed tissue of vaccinated rabbits 10,18. It has been shown to have a potential analgesic effect and is now mainly used to treat chronic pain, especially neuropathic pain 7,19. In this case, we first chose neurotropin as an adjuvant treatment and obtained satisfactory beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Zhu¹,

Zhou

Li³

et al. 2017

JPR

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Spinal cord injury (SCI) complicated by epidural anesthesia, though rare, can result in neuropathic pain. However, the treatment for this kind of life-altering injury remains a challenge. A 7-year-old girl was referred with dyskinesia and severe pain in her right lower extremity due to an accidental SCI following lumbar puncture. After treatment with analgesics such as gabapentin, mecobalamin, and dexamethasone/methylprednisolone for 1 week, the myodynamia had improved, but progressive pain persisted. After treatment with neurotropin, a gradual decrease in visual analog scale score from 7 to 0 was observed. We herein first describe that neurotropin produced sustained relief of pain induced by SCI. This case suggests that neurotropin might be a promising drug in treating pediatric neuropathic pain caused by SCI.

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Section: Discussionmentioning

confidence: 99%

Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Zhu¹,

Zhou

Li³

et al. 2017

JPR

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“…TNC = trigeminal nucleus caudalis; NTG = nitroglycerin; NS = normal saline; NS + NTG = normal saline plus nitroglycerin; 10P + NTG = 10 mg/kg pregabalin plus nitroglycerin; 30P + NTG = 30 mg/kg pregabalin plus nitroglycerin; 30P = 30 mg/kg pregabalin. pain model (Okazaki et al, 2013), and 120 min in partial infraorbital nerve transection rat, a trigeminal neuropathic pain model (Cao et al, 2013). It seems that pregabalin needs a period of 2-3 h to bind to alpha 2 -delta subunits of voltage-gated calcium channels and bring subsequent anti-hyperalgesic effect.…”

Section: Discussionmentioning

confidence: 99%

Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats

Di¹,

Zheng²,

Xiao³

et al. 2015

Neuroscience

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“…There has been growing interest in using drug combination therapy for the alleviation of chronic pain [ 3 , 4 , 8 , 9 ]. The effect of the two drugs in combination could be super additive or synergistic if the results of their actions were higher than the results expected from their individual potencies and efficacies.…”

Section: Discussionmentioning

confidence: 99%

“…The activity of glutaminergic neurons in the spinal cord is greatly increased by inflammation and neuropathic pain conditions. Exaggerated glu activity through NMDA receptors is responsible for central sensitization [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Histogranin is responsible for the partial analgesic effects of adrenal medullary transplantation in the spinal cord of neuropathic rats [ 6 , 7 ]. Several recent studies have reported a much higher efficacy from a precise multi-target combination therapy than from mono-therapy for the management of neuropathic pain [ 3 , 8 , 9 ]. A considerable advantage of using combination therapy is that the active ingredients act on different molecular targets, which enables them to act on more of the signaling cascades involved in pain.…”

Section: Introductionmentioning

confidence: 99%

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Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model

2015

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BackgroundThe present experiment was conducted to identify the cooperative effect of serine histogranin (SHG) and noradrenaline in alleviating peripheral neuropathic pain.MethodsChronic constriction injury of the right sciatic nerve was used to induce chronic neuropathic pain. For drug delivery, a PE10 tube was inserted into the subarachnoid space. Acetone drops and a 44℃ water bath were used to evaluate the cold and heat allodynia, respectively. Placing and grasping reflexes were used to assess the locomotor system.ResultsSHG at 0.5 and 1 µg significantly (P < 0.05) decreased the thermal allodynia. The cold allodynia was also significantly reduced by intrathecal injections of 0.5 (P < 0.05) and 1 µg (P < 0.001) of SHG. 1 µg of noradrenaline, but not 0.5 µg, significantly alleviated the cold (P < 0.01) and thermal (P < 0.05) allodynia. The ameliorating effect of noradrenaline or SHG disappeared when the two compounds were administrated in equal concentrations. A significant difference (P < 0.01 in the acetone and P < 0.05 in the heat) was observed in the groups under equal doses of the two compounds, with a lower effectiveness of the combination therapy.ConclusionsOur findings suggest that the simultaneous administrations of noradrenaline and SHG do not result in synergistic analgesia, and combination therapy may not be a good approach to the treatment of chronic neuropathic pain syndrome.

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Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation

Cited by 13 publications

References 22 publications

Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats

Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model

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