Combined Antimicrobial Activity of Extracts from Quercus infectoria Galls and <i>Scrophularia striata</i> Aerial Parts for an Anticariogenic Herbal Mouthwash

Falakdin, Pooya; Dastan, Dara; Pourmoslemi, Shabnam

doi:10.3831/kpi.2023.26.1.44

Cited by 4 publications

(10 citation statements)

References 33 publications

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“…[7] They are warm in nature and bitter in taste, and have various effects, such as induction of intestinal astringency, cough relief, and enhancement of blood coagulation.Turkish galls have been reported to possess promising antioxidant and anti-inflammatory actions, antimicrobial, antidiabetic, cardioprotective, hepatoprotective, accelerated wound healing, and antitumor effects. [8][9][10][11] Turkish gall extracts are mainly used for clinical treatment of swollen and sore gums, recurrent aphthous ulcer (RAU), and Ulcerative colitis (UC). [12] Turkish galls exhibited antibacterial activity against bacteria known to cause periodontitis and dental caries.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, Turkish galls are abnormal growths produced by gall wasps on gall trees, and are mainly composed of Turkish gallotannins, gallic acid, propionic acid, and resin [7] . They are warm in nature and bitter in taste, and have various effects, such as induction of intestinal astringency, cough relief, and enhancement of blood coagulation.Turkish galls have been reported to possess promising antioxidant and anti–inflammatory actions, antimicrobial, antidiabetic, cardioprotective, hepatoprotective, accelerated wound healing, and antitumor effects [8–11] . Turkish gall extracts are mainly used for clinical treatment of swollen and sore gums, recurrent aphthous ulcer (RAU), and Ulcerative colitis (UC) [12] .…”

Section: Introductionmentioning

confidence: 99%

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Molecular Basis of the Curative Effects of Turkish Gall Extracts on Periodontitis

Luo,

Zha,

et al. 2024

ChemistrySelect

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We explored the mechanism whereby Turkish gall extracts prevent and effectively cure periodontitis. Main bioactive components were obtained from previous reports and targets were screened using TCMSP, PubChem, SwissTargetPrediction, and Drugbank databases. Chronic periodontitis targets were retrieved from OMIM, GeneCards, and DisGeNET databases. Intersectional targets of Turkish galls and periodontitis were obtained using Venn analysis. String databases were used to construct a protein–protein interaction network of common targets. R language was used for GO and KEGG enrichment analyses of common targets. Molecular docking analysis confirmed Turkish gall extract effectiveness for periodontitis treatment, which was verified in vitro and inhibited MAPK1, MAPK3 and SRC expression. We predicted 759 possible target genes. Among 2059 identified periodontitis genes, 205 overlapped with those in methanolic Turkish gall extract. Key targets included JUN, tumor protein 53, MAPK1, MAPK3, STAT3, RELA, and SRC. GO analysis showed that common targets were mainly involved in processes such as oxidative stress. KEGG analysis indicated that common targets were enriched in 163 pathways. Molecular docking analysis showed that 1,2,3,6‐tetra‐O‐galloyl‐β‐D‐glucose, 1,3,6‐tri‐O‐galloyl‐β‐D‐glucose and 1,2,3,4,6‐penta‐O‐galloyl‐β‐D‐glucose were strongly associated with MAPK1, MAPK3, and SRC. Turkish gall extract reduced inflammation and targets expression in vitro, providing a reference for drug development for periodontitis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Basis of the Curative Effects of Turkish Gall Extracts on Periodontitis

Luo,

Zha,

et al. 2024

ChemistrySelect

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“…Based on the inclusion and exclusion criteria, a total of 31 studies are presented and analyzed in this comprehensive review. Table 1 records the in vitro studies conducted from 2019 until 2024 [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], and Table 2 analyzes the in vivo, in situ, and ex vivo clinical studies available in the literature [ 74 , 75 , 76 , 77 , 78 , 79 ]. In both tables, extensive descriptive information on the aim of the study (objectives), the type of experimental and control groups used, the methodological pattern followed, the bacterial strains chosen, and the results that emerged is present.…”

Section: Resultsmentioning

confidence: 99%

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Tzimas,

Antoniadou,

Varzakas

et al. 2024

CIMB

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There is a growing shift from the use of conventional pharmaceutical oral care products to the use of herbal extracts and traditional remedies in dental caries prevention. This is attributed to the potential environmental and health implications of contemporary oral products. This comprehensive review aims at the analysis of plant-derived compounds as preventive modalities in dental caries research. It focuses on data collected from 2019 until recently, trying to emphasize current trends in this topic. The research findings suggest that several plant-derived compounds, either aqueous or ethanolic, exhibit notable antibacterial effects against Streptococcus mutans and other bacteria related to dental caries, with some extracts demonstrating an efficacy comparable to that of chlorhexidine. Furthermore, in vivo studies using plant-derived compounds incorporated in food derivatives, such as lollipops, have shown promising results by significantly reducing Streptococcus mutans in high-risk caries children. In vitro studies on plant-derived compounds have revealed bactericidal and bacteriostatic activity against S. mutans, suggesting their potential use as dental caries preventive agents. Medicinal plants, plant-derived phytochemicals, essential oils, and other food compounds have exhibited promising antimicrobial activity against oral pathogens, either by their anti-adhesion activity, the inhibition of extracellular microbial enzymes, or their direct action on microbial species and acid production. However, further research is needed to assess their antimicrobial activity and to evaluate the cytotoxicity and safety profiles of these plant-derived compounds before their widespread clinical use can be recommended.

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“…A Q. infectoria gall extract possessed efficient antimicrobial activity against Streptococcus mutans, S. sobrinus, and Candida albicans [11]. As this activity was synergistically enhanced in the presence of a Scrophularia striata extract, the two extracts may be used together for preparing dental products with anticariogenic potential.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Pharmacologically, Quercus sp. galls have been reported to possess strong antibacterial, antioxidant, and anti-inflammatory activities, and also antitumor, antifungal, antiviral, antiprotozoal, antiamoebic, antiulcer, larvicidal, tooth and gum tonic, antipyretic, analgesic/local anesthetic, antidiabetic, cardioprotective, hepatoprotective, antiparkinsonian, antitremor, and accelerated wound healing effects [1,3,4,8,9,11,12]. Despite the multiple therapeutic properties, the long-term intake of gallnuts in high doses is not recommended.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Banc,

Rusu,

Filip

et al. 2023

Plants

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Quercus species have been widely used in traditional medicine, and recently, researchers’ attention has focused on galls of the genus Quercus as a source of health-promoting phytochemicals. This review presents a summary of the most recent findings on the phytochemistry and bioactivity of oak galls, following the screening of scientific papers published in two relevant databases, PubMed and Embase, between January 2018 and June 2023. The oak galls are rich in active compounds, mostly gallotannins and phenolic acids. Due to these secondary metabolites, the reviewed studies have demonstrated a wide range of biological activities, including antioxidant and anti-inflammatory actions, antimicrobial properties, tissue-protective effects, and antitumor, anti-aging, and hypoglycemic potential. Thus, oak galls are a promising natural matrix, to be considered in obtaining pharmaceutical and cosmetic preparations used in anti-aging strategies and, together with medications, in the management of age-related diseases. In further evaluations, the valuable functional properties of oak galls, reported mostly in preclinical studies, should be confirmed with clinical studies that would also take into account the potential health risks of their use.

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Combined Antimicrobial Activity of Extracts from Quercus infectoria Galls and Scrophularia striata Aerial Parts for an Anticariogenic Herbal Mouthwash

Cited by 4 publications

References 33 publications

Molecular Basis of the Curative Effects of Turkish Gall Extracts on Periodontitis

Molecular Basis of the Curative Effects of Turkish Gall Extracts on Periodontitis

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

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