Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Wang, Jingxian; Guo-qiang, Song; Li, Aimin; Henkelmann, Bernhard; Pfister, Gerd; Tong, Anthony Z.; Schramm, Karl‐Werner

doi:10.1016/j.chemosphere.2014.01.056

Cited by 10 publications

(8 citation statements)

References 42 publications

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“…The bioavailable water concentrations of more persistent AhR agonists in VOs from TGR ranged from 0.8 to 4.8 pg TCDD L −1 which were much lower compared to effluents from wastewater treatment plants in Australia (0.59-0.98 ng TCDD L − 1 ) Macova et al, 2010), and also lower than some Chinese effluents (b14 pg TCDD EQ L −1 ) (Ma et al, 2005). These values were close to a drinking water reservoir in China (Wang et al, 2014b) and were also below the Drinking Water Maximum Contaminant Level (MCL value) (30 pg TCDD L −1 ), recommended by the US EPA (2011). Although this concentration of AhR agonists in TGR is not alarming right now, the high potential of accumulation of the pollutants in VOs and potential synergistic or antagonistic effects may exhibit a potential hazard on local biota exposed to AhR agonists.…”

Section: Discussionmentioning

confidence: 81%

“…Rastall et al (2004) reported that TEQ PAH were 3 to 4 orders of magnitude lower than the respective TEQ bio in their SPMD samples from a lake in the Balkans. Our recent publication also reported that TEQ cal were 2-10% of TEQ bio in a drinking water reservoir (Wang et al, 2014b). Due to the complex nature of environmental samples together with limited instrumental support, causative agents of observed bioassay reports are often not identified.…”

Section: Discussionmentioning

confidence: 99%

“…The induction of EROD activity was measured upon exposure of rat hepatoma cell lines (H4IIE) to samples according to the description of our recent publication (Wang et al, 2014b). Briefly, cells were grown in Dulbecco's minimum essential medium supplemented with 10% fetal calf serum (DMEM/FC) and incubated at 37°C in a humidified 5% CO 2 incubator.…”

Section: Micro-erod Bioassaymentioning

confidence: 99%

“…Aqueous concentrations of AhR agonists in TGR which considering sampling time and water sampling rate were calculated according to the method described in our recent publication (Wang et al, 2014b). In brief, the aqueous concentrations of AhR agonists are calculated according to the following equation:…”

Section: Aqueous Concentrations Of Ahr Agonists In Tgrmentioning

confidence: 99%

“…Therefore, this device is also referred to as virtual organism (VO) which provides an integrative sampling method for a wide array of bioavailable waterborne HOCs (Schramm et al, 2013). The VO followed by the combination of chemical and biological analyses has been proven to be a resource efficient tool for the exposure assessment of environmentally relevant water borne pollutants in drinking water resources (Rastall et al, 2004;Wang et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

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Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms

Wang

Bernhöft

Pfister

et al. 2014

Science of The Total Environment

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Micro-erod Bioassaymentioning

confidence: 99%

Section: Aqueous Concentrations Of Ahr Agonists In Tgrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms

Wang

Bernhöft

Pfister

et al. 2014

Science of The Total Environment

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Detection of Effects Caused by Very Low Levels of Contaminants in Riverine Sediments Through a Combination of Chemical Analysis, In Vitro Bioassays, and Farmed Fish as Sentinel

Quesada-García

Valdehíta

Olmo

et al. 2015

Arch Environ Contam Toxicol

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Aquatic organisms are often exposed to mixtures of low levels of pollutants whose presence and effects can pass easily unnoticed if only traditional monitoring strategies are employed. The main aim of this work was to assess the presence and effects of trace levels of pollutants in a scarcely affected area through the combination of chemical and biological approaches. Sediments were collected along a river with little anthropogenic pressure and assayed for cytochrome P450 (Cyp1a)-dependent ethoxyresorufin-O-deethylase (EROD) activity with the rainbow trout gonadal cell line RTG-2. Chemical analyses were performed in these sediments using two-dimensional gas chromatography-time-of-flight mass spectrometry. Sediment samples induced EROD activity, and chemical analyses evidenced the presence of a wide variety of contaminants in the range of nanograms per gram of dry weight. Correlation analysis between EROD induction and chemical analyses data showed an r value of 0.840 (p < 0.05). In addition, fish from a fish farm located downstream of the sampling points exhibited high hepatic EROD levels as well as an induced expression of cyp1a and cyp3a. In conclusion, only an appropriate combination of biological and chemical techniques allowed the detection of the presence of trace levels of contaminants in a theoretically nonaffected river.

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Perfluorinated substance assessment in sediments of a large-scale reservoir in Danjiangkou, China

Li²,

Wang

et al. 2018

Environ Monit Assess

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The occurrence of eight perfluorinated compounds (PFCs) in the surface sediments from 10 sampling sites spread across the Danjiangkou Reservoir was investigated by isotope dilution ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) after solid-phase extraction (SPE). All the sediments from the 10 sites contained detectable levels of PFCs. The total concentration of the target PFCs in each sediment sample (C) ranged from 0.270 to 0.395 ng g of dry weight, and the mean value of C was 0.324 ± 0.045 ng g of dry weight for the whole reservoir. For each perfluorinated compound in one sediment, perfluorooctane sulfonate (PFOS) or perfluoro-n-butanoic acid (PFBA) consistently had a higher concentration than the other six PFCs, while perfluoro-n-octanoic acid (PFOA) was always undetectable. In terms of spatial distribution, the total and individual concentrations of PFCs in sediment from downstream sites of the Danjiangkou Reservoir were higher than those from upstream sites. Factor analysis revealed that PFCs in the sediment samples originated from electroplating and anti-fog agents in industry, food/pharmaceutical packaging and the water/oil repellent paper coating, and the deposition process. The quotient method was utilized to assess the ecological risk of PFCs in the sediments of the Danjiangkou Reservoir, which showed that the concentrations of PFCs were not considered a risk. In this study, detailed information on the concentration level and distribution of PFCs in the sediments of the Danjiangkou Reservoir, which is the source of water for the Middle Route Project of the South-to-North Water Transfer Scheme in China, was reported and analyzed for the first time. These results can provide valuable information for water resource management and pollution control in the Danjiangkou Reservoir.

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Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Cited by 10 publications

References 42 publications

Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms

Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms

Detection of Effects Caused by Very Low Levels of Contaminants in Riverine Sediments Through a Combination of Chemical Analysis, In Vitro Bioassays, and Farmed Fish as Sentinel

Perfluorinated substance assessment in sediments of a large-scale reservoir in Danjiangkou, China

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