Combined Complex Skin Repair in Patient With Extensive Burns: A Case Report

Abstract

Auto-skin grafting is the current treatment of choice for extensive burns. Nevertheless, the lack of donor sites for skin grafting remains one of the greatest limiting factors for the treatment of extensively burned patients. We present the case of a 53-year-old male patient with deep and full thickness burns on 91% of the total body surface area. We used the Meek technique for split-thickness skin graft expansion to treat this patient. In order to obtain sufficient skin for grafting, we repeatedly harvested the same anatomical areas. Acceleration of burn wounds, recipient, and donor site healing was achieved by systemic treatment with recombinant human growth hormone and topical recombinant human epidermal growth factors. This combined, complex treatment modality contributed to the successful skin repair in this patient.

Comparison of the Effectiveness of Methods for Obtaining and Application the Stromal-Vascular Fraction of Adipose Tissue in an Experimental Model of a Donor Wound in Burns

“…Уральский медицинский журнал umjusmu.ru Оригинальная статья блема, актуальность которой возрастает при общей площади поражения свыше 60 % поверхности тела, -дефицит пластических ресурсов аутологичной кожи [1,2]. Решением может стать качественное ускорение заживления донорских ран -источников пластического материала.…”

Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Micro Vessel Density

“…It was found that the levels of IL-6 and TNF-α were reduced in group B and that they were decreased in group C as shown in Table 5. Burns are injuries to the skin, respiratory system or body organs caused by accidental exposure to flames, hot liquids, chemicals, electricity or radiation [7] . When the human body experiences burns, the integrity of the skin tissue will be destroyed, and its barrier defense function will also be affected.…”

“…When the human body experiences burns, the integrity of the skin tissue will be destroyed, and its barrier defense function will also be affected. At the same time, a large number of cells and blood vessels in the deep tissue of the human body will also be damaged to varying degrees [8] . Severe pain can lead to stress response and shock caused by a large amount of body fluid loss, changing the homeostasis of the body's internal environment, resulting in immune dysfunction after burn.…”

“…Burn wound healing is a complex process, including inflammatory process and the release of a variety of growth factors. Previous studies have shown that VEGF is a highly specific VEGF, which can promote vascular endothelial cell migration, extracellular matrix degeneration and other physiological effects [8] . As we all know, growth hormone is one of the molecules with multiple effects on skin cells.…”