Combined daylight and conventional photodynamic therapy with 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) for actinic keratosis of the face and scalp: a new and efficient approach

Salido‐Vallejo, Rafael; Jiménez-Nájar, F; Garnacho‐Sucedo, G.; Vélez, Alberto

doi:10.1007/s00403-019-02028-2

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…The results of this study showed a reduction rate of 82.7% and 56.8% in the groups treated with combPDT and daylight PDT, respectively. These differences were statistically significant for grade I lesions ( P = .04) but not for grade II lesions 15 . Local skin reactions and patient pain were higher in the combPDT group, but this did not affect the tolerability of the treatment.…”

Section: Discussionmentioning

confidence: 79%

“…The progressive activation of synthetized PpIX during the DL‐PDT reduces the pain and local skin reactions of these procedures. Additionally, the subsequent illumination with a red 635 nm light achieves the activation of remaining PpIX concentration and the increase of clearance rates but not of local skin reactions 15 . Nonetheless, almost all of these local symptoms disappeared 1 week after treatment—except flaking, which occurred in 23 of the 26 subjects in the cPDT group.…”

Section: Discussionmentioning

confidence: 94%

“…For this reason, different alternatives have been used for the treatment of AKs, such as daylight photodynamic therapy (dPDT) or the combination of dPDT and cPDT—one dPDT session according to the Spanish‐Portuguese consensus statement, followed immediately by cPDT 13 . These have had similar results in AK clearance rates, especially in grade I AKs, and a similar tolerability profile when compared with dPDT alone 12,14,15 . However, there are few studies about this new combined photodynamic therapy, none of which compare it to cPDT.…”

Section: Introductionmentioning

confidence: 99%

“…13 These have had similar results in AK clearance rates, especially in grade I AKs, and a similar tolerability profile when compared with dPDT alone. 12,14,15 However, there are few studies about this new combined photodynamic therapy, none of which compare it to cPDT.…”

Section: Introductionmentioning

confidence: 99%

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Combined versus conventional photodynamic therapy with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for actinic keratosis: A randomized, single‐blind, prospective study

Sáenz‐Guirado

Cuenca‐Barrales

Vega-Castillo

et al. 2021

Photoderm Photoimm Photomed

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Background: Photodynamic therapy (PDT) has become one of the most effective therapies for the treatment of actinic keratosis, allowing the removal of more than one lesion in a single session. However, the pain sustained by the patient during treatment and local skin reactions can limit its use. Objectives:To determine the efficacy and safety of combined PDT (daylight PDT followed by conventional PDT) vs conventional PDT 12 weeks after treatment. Methods:The study was performed as a randomized, single-center, non-inferiority clinical trial with two parallel groups. A total of 51 patients with grade I and II AKs on the scalp or face were randomized. Twenty-five patients received one session of combined PDT (combPDT), and 26 patients received one session of conventional PDT (cPDT). The primary endpoint was the reduction of AKs, 12 weeks after treatment.The secondary endpoint was the reduction in pain and local skin reaction. Results:The reduction rate of grade I and II AKs was similar in combPDT and cPDT, showing no statistically significant differences between both groups, 76.67% vs 86.63% [P = .094] and 80.48% vs 83.08% [P = .679], respectively. However, pain was significantly lower in the combPDT group (2.56 vs 5, P < .01), as were local skin reactions. Conclusions:CombPDT has proven to be as effective as cPDT for the treatment of grade I and II AKs located on the scalp and face. Furthermore, combPDT has been shown to be considerably more tolerable than cPDT, causing only mild local skin reactions.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined versus conventional photodynamic therapy with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for actinic keratosis: A randomized, single‐blind, prospective study

Sáenz‐Guirado

Cuenca‐Barrales

Vega-Castillo

et al. 2021

Photoderm Photoimm Photomed

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“…The combination of daylight and conventional PDT with BP-200 ALA could further increase the efficacy of daylight PDT with higher clearance rates of AK lesions. However, a mild increase in the pain during the red light illumination was detected (visual analogue scale (VAS) 3.4 vs. 0.6) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy with 5-Aminolevulinic Acid Patch for the Treatment of Actinic Keratosis

Kiss

Farkas

Tosti

et al. 2022

JCM

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Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an emerging treatment option in the care of actinic keratosis (AK). A self-adhesive 5-ALA patch was recently developed that allows a precise PDT procedure. Here, we review the current literature and report the findings of our case series that observed the outcomes and safety of 5-ALA patch PDT. Ten patients with a total of 40 AKs were treated with a single session of conventional or daylight PDT using 5-ALA patch at the Department of Dermatology and Venereology, Sapienza University of Rome or at the European Institute of Oncology, Milan, Italy. Complete response was observed in three patients, while partial response was seen in seven patients. Overall tolerability was good or excellent, with local adverse events observed in four patients. This is the first case series reported where the 5-ALA patch was applied using daylight PDT, and its efficacy and tolerability in the treatment of AK were demonstrated. In conclusion, the self-adhesive 5-ALA patch is a convenient application of PDT that provides a well-tolerated and effective treatment option with satisfactory cosmetic outcomes.

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Aktinische Keratosen

et al. 2020

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Combined daylight and conventional photodynamic therapy with 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) for actinic keratosis of the face and scalp: a new and efficient approach

Cited by 9 publications

References 18 publications

Combined versus conventional photodynamic therapy with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for actinic keratosis: A randomized, single‐blind, prospective study

Combined versus conventional photodynamic therapy with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for actinic keratosis: A randomized, single‐blind, prospective study

Photodynamic Therapy with 5-Aminolevulinic Acid Patch for the Treatment of Actinic Keratosis

Aktinische Keratosen

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