Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

Kim, Nayoung; Yoon, Young‐In; Yoo, Hyun Ju; Tak, Eunyoung; Ahn, Chul‐Soo; Song, Gi‐Won; Lee, Sung‐Gyu; Hwang, Shin

doi:10.14348/molcells.2016.0130

Cited by 24 publications

(15 citation statements)

References 22 publications

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“…These results corroborate those of other studies performed in either humans or rats . In fact, raised serum IL‐17 at D7 posttransplantation was predictive of liver rejection 2 wk later, whereas there was an obvious trend toward higher IL‐17 level in bronchoalveolar lavage fluid (BALF) in patients who experienced AR after lung transplantation . Moreover, we noted a significant increase in IL‐17A between D–1 and D7 in KTRs who experienced AR, P < 10 –4 .…”

Section: Discussionsupporting

confidence: 91%

“…Inversely, and at D7 posttransplantation, IL‐17A, IL‐17F, and IL‐23 plasma levels were significantly augmented in KTRs who experienced AR ( P < 10 –14 , P = 0.015, and P < 10 –17 , respectively). These results corroborate those of other studies performed in either humans or rats . In fact, raised serum IL‐17 at D7 posttransplantation was predictive of liver rejection 2 wk later, whereas there was an obvious trend toward higher IL‐17 level in bronchoalveolar lavage fluid (BALF) in patients who experienced AR after lung transplantation .…”

Section: Discussionsupporting

confidence: 89%

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The role of IL-23/IL-17 axis in human kidney allograft rejection

Haouami

Dhaouadi

Sfar

et al. 2018

Journal of Leukocyte Biology

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Th17 cell subset has been implicated in autoimmune diseases, tumor immunity and, transplant rejection. In order to investigate the role of IL-17/IL-23 pathway in allograft outcome, intragraft expression of IL-17 mRNA and single nucleotide polymorphisms (SNPs) of IL-17A, IL-17F, IL-17RC, and IL23R genes were evaluated with a quantification of IL-17A, IL-17F, and IL-23 plasma levels. This study revealed that recipients with acute rejection (AR) had a significant increase in IL-17A mRNA expression levels after transplantation compared to controls (P = 0.037). Moreover, IL-17A plasma levels were significantly higher in AR group; pretransplantation (Day-1 [D-1]): P = 0.00022 and posttransplantation (Day 7 [D7]): P < 10 . IL-17F and IL-23 plasma levels were significantly higher in AR at D7 only (47.86 vs. 22.99 pg/ml; and 33.82 vs. 18.811 pg/ml; P = 0.015 and P < 10 , respectively). Using receiver-operating characteristic curves, D7 IL-17A and IL-23 plasma levels exhibited excellent sensitivities and specificities for predicting AR. Genetic study revealed no association between IL-17A, IL-17F, IL-17RC, and IL23R studied SNPs and AR. Nevertheless, a significant improvement of graft survival was found in kidney transplant recipients carrying IL-17F-rs763780*A/A, IL-17RC*G/G, and *G/A genotypes. Besides, IL-17A mRNA levels were significantly higher in patients carrying the IL-23R*G/G genotype comparatively to those with *G/A genotype. Based on these findings, significant increase of IL-17A mRNA and protein levels in AR recipients that are genetically controlled highlights the role of this cytokine that can be a useful clinical biomarker to predict early acute renal allograft rejection.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

The role of IL-23/IL-17 axis in human kidney allograft rejection

Haouami

Dhaouadi

Sfar

et al. 2018

Journal of Leukocyte Biology

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“…Allen et al 47 reported that a preoperative inflammatory state in the recipient, as indicated by high levels of serum IL-10 and MCP-1 has an important impact for early lung allograft function. Kim et al 48 showed an association of combined detection of serum IL-10, IL-17, and IP-10 with acute rejection following adult liver transplantation. Crescioli et al 49 reported that pretransplant serum CXCL10 can be a predictive marker for cardiac acute rejection.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty

Yazu

Yamaguchi

Aketa

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Citation: Yazu H, Yamaguchi T, Aketa N, et al. Preoperative aqueous cytokine levels are associated with endothelial cell loss after Descemet's stripping automated endothelial keratoplasty. Invest Ophthalmol Vis Sci. 2018;59:612-620. https://doi.org/ 10.1167/iovs.17-23049 PURPOSE. To evaluate the association between endothelial cell density (ECD) after Descemet's stripping automated endothelial keratoplasty (DSAEK) and preoperative cytokine levels in the aqueous humor (AqH).METHODS. This prospective consecutive case series included 97 consecutive patients who underwent DSAEK (64 eyes) or cataract surgery (33 eyes). AqH samples were collected at the beginning of each surgery. The levels of cytokines (IL-1a, IL-1b, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IFN-a, IFN-c, monocyte chemotactic protein [MCP]-1, E-selectin, P-selectin, and soluble intercellular adhesion molecule [sICAM]-1) in the AqH were measured by multiplex beads immunoassay. The correlations between preoperative aqueous cytokine levels and the ECD at 12 months after DSAEK were analyzed.RESULTS. The ECD decreased from 2747 6 259 cells/mm 2 in the donor graft to 1235 6 607 cells/mm 2 at 12 months after DSAEK. In all subjects undergoing DSAEK, the postoperative ECD at 12 months was significantly correlated with the preoperative levels of MCP-1 (r ¼ À0.467, 95% confidence interval [CI]: À0.650 to À0.222, P ¼ 0.0003). In an analysis excluding Fuchs endothelial corneal dystrophy (11 eyes), the ECD at 12 months after DSAEK was significantly correlated with preoperative levels of IL-17A (r ¼ À0.635, 95% CI: À0.819 to À0.319, P ¼ 0.0004), MCP-1 (r ¼ À0.605, 95% CI: À0.779 to À0.345, P < 0.0001), IFN-c (r ¼ À0.633, 95% CI: À0.796 to À0.385, P < 0.0001), E-selectin (r ¼ À0.516, 95% CI: À0.756 to À0.276, P ¼ 0.0004), and sICAM-1 (r ¼ À0.537, 95% CI: À0.735 to À0.253, P ¼ 0.0005).CONCLUSIONS. Higher preoperative levels of IL-17A, MCP-1, IFN-c, E-selectin, and sICAM-1 in the AqH were associated with lower ECD after DSAEK for bullous keratopathy.

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“…Cytokine secretion can modulate the immune response and is consequently associated with post‐transplantation outcomes in allotransplantation studies . Previous research has shown that after transplantation from GTKO pigs to baboons, certain cytokines were significantly elevated, and inflammatory responses preceded the activation of coagulation .…”

Section: Discussionmentioning

confidence: 99%