Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type <i>Drosophila melanogaster</i>

Ayikobua, Emmanuel Tiyo; Semuyaba, Ibrahim; Eze, Daniel Ejike; Kalange, Muhamudu; Nansunga, Mariam; Okpanachi, Alfred Omachonu; Safiriyu, Abass Alao

doi:10.1155/2018/3717328

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…In this way, several drugs and natural extracts are tested for this purpose. Among them are omega 3, turmeric, and propolis (Ayikobua et al, 2018;de Oliveira Souza et al, 2019;Mishra & Palanivelu, 2008). Our study correlated acetylsalicylic acid, commonly known as aspirin, to a neuroprotective effect on the brain of D. melanogaster.…”

Section: Discussionmentioning

confidence: 74%

Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster

Carmo¹,

Figueiredo²,

Souza³

et al. 2021

RSD

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Acetylsalicylic acid or aspirin is the most widely used drug globally for its anti-inflammatory characteristics, although little is known about its actions on the central nervous system (CNS). We investigated aspirin's potential neuroprotective effects against paraquat-induced neurotoxicity (PQ) in the present study. Adult male wild-type flies were exposed to a diet containing PQ (3 mM) and/or aspirin (1 μM; 5 μM; 10 μM). Flies fed with PQ reduced locomotion and increased mortality. PQ-induced neurotoxicity has also been associated with a marked decrease in acetylcholinesterase (AChE) activity and lipid peroxidation. Co-exposure to aspirin (5 μM) increased survival, improved motor performance, increased AChE activity, and decreased lipid peroxidation. Our results suggest aspirin's neuroprotective effects, probably due to its lysosomal action and antioxidant characteristics. Thus, we demonstrate that the Drosophila melanogaster model can elucidate basic aspirin mechanisms to assist the evaluations carried out in higher animals to minimize the neurodegenerative effects caused by diseases such as Parkinson's and Alzheimer's.

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Section: Discussionmentioning

confidence: 74%

Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster

Carmo¹,

Figueiredo²,

Souza³

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…This study has shown that acute exposure of D. melanogaster to AlCl 3 at a concentration as low as 40 mM is capable of significantly decreasing their survival, locomotors performance, and aversive phototaxic suppression (APS). Both the locomotor performance and APS are validly used in drosophila to access neuromuscular functions, aging, learning, and memory (Ali, Escala, Ruan, & Zhai, 2011; Ayikobua et al, 2018). Therefore, our findings further confirms the potent toxicity of Al in D. melanogaster, especially to the fly's neuronal system.…”

Section: Discussionmentioning

confidence: 99%

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

et al. 2020

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The pathogenesis of several neurodegenerative diseases have been identified to be both genetic and sporadic; considering the latter, environmental risk factors are very prominent. One of the most ubiquitous element in the environment is aluminum (Al), valuable for producing various domestic and industrial products for human uses (Bayliak et al., 2019; Liu et al., 2018). Physiologically, Al is a nonessential metal and excessive exposure to it has been

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“… Ayikobua et al (2018) investigated the combined effect of donepezil and ethanolic extract of propolis (source not specified) in wild-type Drosophila melanogaster ( n = 10 each group) ( Ayikobua, Semuyaba, 2018 ). Their results demonstrated that 10 ml of donepezil (0.001 M) combined with 50 mg propolis in food exhibited a time-dependent improvement trend in the short- and long-term memory for 30 days.…”

Section: Pharmacodynamic Interactionsmentioning

confidence: 99%

An Overview of the Evidence and Mechanism of Drug–Herb Interactions Between Propolis and Pharmaceutical Drugs

et al. 2022

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With the growing interest in the medicinal use of propolis, numerous studies have reported significant interactions between propolis extract and pharmaceutical drugs which may result in great clinical benefits or risks. The present study aims to review the drug–herb interactions of the full-spectrum propolis extract and main pharmaceutical drugs from the pharmacodynamic and pharmacokinetic aspects and elucidate the underlying pharmacological mechanisms. A literature search was conducted between June 2021 and February 2022 in Google Scholar, PubMed, MEDLINE, and EMBASE databases to include English studies from years 2000 to 2022 that evaluated the interaction of full-spectrum propolis extract and standard pharmaceutical drugs/cytochromes P450s. Studies that looked into geopropolis, propolis fractions, and isolated compounds, or interaction of propolis with foods, bioactive molecules, or receptors other than standard pharmaceutical drugs were excluded. From a pharmacodynamic perspective, propolis extract exhibited positive or synergistic interaction with several chemotherapeutic drugs by enhancing antitumor activity, sensitizing the chemoresistance cell lines, and attenuating multi-organ toxicity. The molecular mechanisms were associated with upregulating the apoptotic signal and immunomodulatory activity and attenuating oxidative damage. Propolis extract also enhanced the anti-bacterial and antifungal activities of many antimicrobial drugs against sensitive and resistant organisms, with an effect against the gram-positive bacteria stronger than that of the gram-negative bacteria. The synergistic action was related to strengthened action on interfering cell wall integrity and protein synthesis. The strong antioxidant activity of propolis also strengthened the therapeutic effect of metformin in attenuating hyperglycemia and pancreatic damage, as well as mitigating oxidative stress in the liver, kidney, and testis. In addition, propolis showed a potential capacity to enhance short-term and long-term memory function together with donepezil and improve motor function with levodopa and parasite killing activity with praziquantel. Pharmacokinetic studies showed inhibitory activities of propolis extracts on several CYP450 enzymes in vitro and in vivo. However, the effects on those CYP450 were deemed insignificant in humans, which may be attributed to the low bioavailability of the contributing bioactive compounds when administered in the body. The enhanced bioactivities of propolis and main pharmaceutical drugs support using propolis in integrative medicine in anti-cancer, anti-microbial, antidiabetic, and neurological disorders, with a low risk of altered pharmacokinetic activities.

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Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type Drosophila melanogaster

Cited by 12 publications

References 33 publications

Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster

Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

An Overview of the Evidence and Mechanism of Drug–Herb Interactions Between Propolis and Pharmaceutical Drugs

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