Combined effect of herpes simplex virus and tobacco on the histopathologic changes in lips of mice

Park, N.-H.; Herbosa, Eugenio G.; Niukian, Khadjik; Shklar, Gerald

doi:10.1016/0030-4220(85)90008-8

Cited by 24 publications

(3 citation statements)

References 29 publications

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“…The traditional list of etiologieal faetors related to oral eateinomas ineludes tobacco, aleohol, syphilis and oral sepsis (33). Additionally, Shillitoe et al (34) found elevated antibody titers to Herpes simplex I antigens in patients with oral cancer, and the studies of Park et al (35) indicate a synergistie effeet of I-ISV and tobacco in the produetion of oral epithelial dysplasia in miee. Human papilloniaviruses have been detected by imtiiunologieal and eleetron tnieroscopieal tnethods in various benign oral lesions sueh as papillotnas, eondylomas, focal epithelial hyperplasia, fibrous hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Detection of papillomavirus DNA in oral papillomas and carcinomas: application of in situ hybridization with biotinylated HPV 16 probes

Milde¹,

Löning²

1986

J Oral Pathology Medicine

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Four oral papillomas and 7 carcinomas were studied for the presence of HPV DNA by means of in situ hybridization. Hybridization was carried out with a HPV 16 probe labelled with biotin under different conditions (nick translation/photobiotin). Subsequently, a modified biotin‐avidin‐alkaline phosphatase procedure was used to visualize virus infected cells. Four/4 papillomas and 4/7 carcinomas were seen to contain HPV harbouring cells. Positive cells were located at intermediate and superficial cell layers in papillomas and in keratinized zones in carcinomas. Analogous results were found with nick translated and photobiotinylated probes. DNA‐biotinylation in conjunction with the biotin‐avidin‐alkaline phosphatase detection system proved lo be a sensitive, convenient and rapid modification of in situ hybridization.

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Section: Discussionmentioning

confidence: 99%

Detection of papillomavirus DNA in oral papillomas and carcinomas: application of in situ hybridization with biotinylated HPV 16 probes

Milde¹,

Löning²

1986

J Oral Pathology Medicine

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“…In addition, there is evidence that herpes simplex virus (HSV) Type I may be associated with oral carcinoma (1 5-18). Herpes simplex antibody titers are increased in patients with oral carcinoma (181, and HSV antigens and RNA complementary to HSV-DNA have been found in tissues from human carcinoma, and HSV-1 and smokeless tobacco have been shown to act synergistically to produce oral carcinoma in animals (19,20). While proof of a relationship between HSV-1 and oral carcinoma does not exist, such studies suggest a need for concern in a population with both a high prevalence of RHL and tobacco use such as the military population.…”

mentioning

confidence: 99%

The Prevalence of Recurrent Herpes Labialis during an Army Hot Weather Exercise

Shulman¹,

Carpenter

Lewis³

1992

J Public Health Dent

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A survey was performed on 1,062 of 2,500 (42%) Army personnel participating in a desert training exercise at Fort Irwin, California, in September 1983. The prevalence of recurrent herpes labialis (RHL) and chapped lips was observed during the third week of a four-week training period. Complexion, sex, lip protectant use, age, and time spent outdoors were obtained by observation and interview. Recurrent herpes labialis was found in 46 subjects (4%). Stratified analysis and stepwise logistic regression were used to identify risk factors associated with RHL and to determine the prevalence odds ratios (POR). Risk factors with statistically significant associations with RHL were lip protectant use (POR = 0.19), chapped lips (POR = 2.87), being female (POR = 5.00), and light complexion (POR = 2.48). These findings strongly support the use of lip protectants during prolonged exposure to hot, dry climates as a prophylaxis against recurrent herpes labialis. Additional studies should focus on excitatory factors of RHL; and clinical trials of the efficacy of the lip protectants to protect against RHL and chapped lips should be undertaken.

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“…Involvement of other contributing co-factors such as alcohol (Williams and Horm, 1977;Istvan and Matarazzo, 1984), nutritional deficiencies (Heimburger et al, 1988;Chen et al, 1989;Stich and Anders, 1989), and virus (Shillitoe et al, 1982;Park et al, 1985Park et al, , 1986Greer et al, 1990;Palefsky, 1991;Park, 1991) Percentages of cells (A, RKO; B, NHOK; C, SCC-9) at either GO/G1, S, or G2/M phases with or without 200 mM ethanol are shown. Ethanol treatment induced cell cycle arrest at G1 in all cells tested (Guo et al, 1997).…”

Section: (1) Tobacco-specific Chemical Carcinogensmentioning

confidence: 99%

Conversion of Normal To Malignant Phenotype: Telomere Shortening, Telomerase Activation, and Genomic Instability During Immortalization of Human Oral Keratinocytes

Kang

Park

2001

Critical Reviews in Oral Biology & Medicine

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shorten. In a few immortal clones surviving beyond the crisis, we found a marked elevation of telomerase activity and stabilization of telomere length. Furthermore, the E6 and E7 oncoproteins of "high risk" HPV disrupted the cell cycle control and DNA repair in immortalized HOK, and enhanced mutation frequency resulting from genomic instability. However, HPV infection alone failed to give rise to a tumorigenic cell population, which required further exposure to chemical carcinogens in addition to HPV infection. Analysis of the data presented suggests that oral carcinogenesis is a series of discrete genetic alterations that result from a continued genotoxic challenge by environmental risk factors. Our in vitro model may be useful for investigators with interest in furthering our understanding of oral carcinogenesis.

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Combined effect of herpes simplex virus and tobacco on the histopathologic changes in lips of mice

Cited by 24 publications

References 29 publications

Detection of papillomavirus DNA in oral papillomas and carcinomas: application of in situ hybridization with biotinylated HPV 16 probes

Detection of papillomavirus DNA in oral papillomas and carcinomas: application of in situ hybridization with biotinylated HPV 16 probes

The Prevalence of Recurrent Herpes Labialis during an Army Hot Weather Exercise

Conversion of Normal To Malignant Phenotype: Telomere Shortening, Telomerase Activation, and Genomic Instability During Immortalization of Human Oral Keratinocytes

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