Combined Effect of Lead Exposure and Allostatic Load on Cardiovascular Disease Mortality—A Preliminary Study

Obeng-Gyasi, Emmanuel; Ferguson, Alesia C.; Stamatakis, Katherine A.; Province, Michael A.

doi:10.3390/ijerph18136879

Cited by 24 publications

(15 citation statements)

References 71 publications

(81 reference statements)

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“…The association between AL and gender was significant; this was similar to the findings of Juster et al and of others [ 34 , 35 ], which indicated that males have higher AL levels than females.…”

Section: Discussionsupporting

confidence: 91%

Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Bashir

Obeng-Gyasi

2022

Diseases

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Objective: This study sought to assess the associations between occupation, serum concentrations of selected of Per- and Polyfluoroalkyl Substances (PFAS), and chronic physiological stress, as operationalized by Allostatic Load (AL), among adults aged ≥20 years. Methods: To explore the interactions of occupation with PFAS levels and AL, data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 were used. We performed Poisson regression modeling to evaluate AL’s relationships with PFAS concentrations and occupations on weighted data. Results: The results demonstrated that increased AL was positively associated with different occupation groups such as a) Public Administration and b) Arts, Entertainment, and Recreation (p-values 0.018 and 0.002, respectively), and with certain PFAS concentrations (Perfluorooctanoic acid, PFOA, p-value = 0.002). Finally, AL had a strong association with the interaction of some PFAS such as Perfluorobutane sulfonic acid (PFBS) and occupation (AL: PFBS: occupation, p-value < 0.0001), with different association measures existing across varying occupations. Conclusions: Occupation and PFOA seem to be associated with AL. This suggests the need of implementing further strategies to limit the exposure to stressors and PFAS in the work environment to promote longevity among the workforce in the U.S. Finally, policymakers must do more to clearly define standards and regulations in the work environment related to PFAS exposure.

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Section: Discussionsupporting

confidence: 91%

Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Bashir

Obeng-Gyasi

2022

Diseases

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“…Lead (Pb) is a widespread and harmful environmental toxicant [1][2][3] that causes adverse health effects in children, particularly neurological and neurobehavioral deficits, lower IQ, slowed growth and anemia [4][5][6][7]. In addition, the health effects of Pb over the life course have been documented, including adverse effects on the cardiovascular [8,9], renal and hepatic systems [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Reduction in Blood Lead Concentration in Children across the Republic of Georgia following Interventions to Address Widespread Exceedance of Reference Value in 2019

Ruadze

Leonardi

Saei³

et al. 2021

IJERPH

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In recent years, reports of lead contamination have dramatically increased in Georgia. Given concerns about the exposure of children to lead (Pb), the National Multiple Indicator Cluster Survey (MICS-2018) included a blood sampling component. The results showed that 41% of the children that participated had blood Pb levels (BLL) ≥ 5 µg/dL and that BLL in children living in Western Georgia were higher than those in Eastern regions. In response to these findings, NCDC implemented written and verbal advice to the families of children who participated in the MICS-2018 on how to reduce Pb exposure. From August 2019 onwards, the state program of clinical follow-up was implemented. The design of this study was a longitudinal study. The intervention of interest was the public health advice and medical follow-up, and the outcome was defined as the difference in BLL between the MICS-2018 survey and the state program follow-up. We observed a significant overall reduction in median BLL between MICS-2018 and state program follow-up in both August 2019 and the latest results (until December 2019). However, we did not observe any significant further reduction between August and the most recent BLL results. In the Georgian setting, written and verbal communication targeting individual households, alongside home visits to the most exposed, effectively reduced BLL in children.

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“…Potential covariates may confound the association between BLL and AAC were summarized in our multivariable-adjusted models based on previous studies (26,(30)(31)(32). Continuous variables in our study included age, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine, serum cotinine, hemoglobin A1c, serum uric acid, serum calcium, serum phosphorus, total cholesterol, and total 25hydroxyvitamin D. Categorical variables included gender, race, education level, body mass index (BMI), hypertension, and diabetes.…”

Section: Covariatesmentioning

confidence: 99%

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Zheng

et al. 2021

Front. Cardiovasc. Med.

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Aims: This study aimed to evaluate the association between blood lead level (BLL) and abdominal aortic calcification (AAC) in US adults aged ≥40 years.Methods: We obtained data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES). Participants missing the data of BLL and AAC scores were excluded. BLL was measured using inductively coupled plasma mass spectrometry directly. AAC scores were quantified by Kauppila score system, and severe AAC was defined as AAC score >6. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between BLL with AAC score and severe AAC.Results: A total of 1,530 participants were included with the mean BLL of 1.45 ± 1.31 ng/dl and mean AAC score of 1.40 ± 3.13. The prevalence of severe AAC was 7.98% overall, and participants in higher BLL quartile showed higher prevalence of severe AAC (Quartile 1: 3.55%, Quartile 2: 7.28%, Quartile 3: 9.88%, Quartile 4: 12.58%, P < 0.0001). BLL was positively associated with higher AAC score (β = 0.15, 95% CI: 0.02, 0.27, P = 0.021) and increased risk of severe AAC (OR = 1.11; 95% CI: 1.00–1.22; P = 0.047). Subgroup analysis and interaction test indicated that the association between BLL and AAC was similar in different population settings.Conclusions: Higher BLL was associated with higher AAC score and increased risk of severe AAC. Lead burden should be considered for people with AAC in clinical settings.

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Combined Effect of Lead Exposure and Allostatic Load on Cardiovascular Disease Mortality—A Preliminary Study

Cited by 24 publications

References 71 publications

Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Reduction in Blood Lead Concentration in Children across the Republic of Georgia following Interventions to Address Widespread Exceedance of Reference Value in 2019

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

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