Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Abstract

The objective of this study was to investigate whether the mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modifies the effects of coffee consumption on serum lipid levels and the risk of dyslipidemia in middle-aged Japanese men. A total of 397 male subjects (age, 53.9±7.8 years; mean±s.d.) were selected from among individuals visiting the hospital for regular medical check-ups. After adjustment for age, body mass index, habitual alcohol consumption, habitual smoking and use of antihypertensive medication, among subjects who consumed o1 cup of coffee per day, the odds ratio (OR) for hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol X140 mg per 100 ml) was significantly lower in those with Mt5178A than in those with Mt5178C (OR¼0.378, 95% confidence interval: 0.153-0.919). After adjustment, the association between the Mt5178A genotype and hyper-LDL cholesterolemia depended on coffee consumption (P for trend¼0.018). Coffee consumption was positively associated with serum LDL cholesterol levels only in subjects with Mt5178A. However, in subjects with Mt5178C, serum LDL cholesterol level or risk of hyper-LDL cholesterolemia did not seem to depend on coffee consumption. These results suggest that for men with Mt5178A, coffee consumption negates the genetic benefit of lower risk for hyper-LDL cholesterolemia.

Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men: a cross-sectional study

“…The present study shows that coffee consumption may decrease the number of CRF components among Mt5178C genotypic men, and previous studies have reported that coffee consumption decreases the risk of hypertension [10] and AGT [12]. On the other hand, the present study shows that coffee consumption may increase the number of CRF components among Mt5178A genotypic men, and a previous study reported that coffee consumption increases the risk of hyper-LDL cholesterolemia among Mt5178A genotypic men [11]. The present study shows a U-shaped association between the frequency of alcohol consumption and the clustering of CRFs among Mt5178C genotypic men.…”

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis

“…Previous cross-sectional studies reported the joint effects of Mt5178 C/A polymorphism and coffee consumption on the risk of hypertension [16], risk of hyper-LDL cholesterolemia [17] and clustering of cardiovascular risk factors [18]. Amongst men with Mt5178C genotype, the risk of hypertension was significantly lower in those who consumed ≥2 cups of coffee per day than in those who consumed ≤1 cup of coffee per day [16].…”

“…The risk of the clustering of cardiovascular risk factors was significantly lower in those who consumed ≥1 cup of coffee per day than in those who consumed <1 cup of coffee per day [18]. Amongst Mt5178A genotypic men, the risk of hyper-LDL cholesterolemia was significantly higher in those who consumed ≥1 cup of coffee per day than in those who consumed <1 cup of coffee per day [17]. Taken together, the present results do not suggest that coffee intake is more beneficial for health in men with Mt5178C than in those with Mt5178A.…”

“…A survey of coffee intake, habitual smoking, alcohol consumption and green tea intake was performed using a questionnaire. As in previous reports [17, 18], coffee consumption was categorized based on the number of cups of coffee per day (<1 cup per day, 1 to 3 cups per day, ≥4 cups per day). Habitual smoking was classified as non- or ex-smokers and current smokers.…”

“…Moreover, Mt5178 C/A polymorphism interacts with several lifestyle habits, namely habitual smoking [11–14], alcohol consumption [6, 14, 15], coffee consumption [16–18] and green tea consumption [19], on the risk of lifestyle-related diseases. Mt5178 C/A polymorphism influences the effects of coffee consumption on the risk of hypertension [16], hyper-low-density lipoprotein (LDL) cholesterolemia [17] and the clustering of cardiovascular risk factors [18]. …”