Combined effect of metformin and gallic acid on inflammation, antioxidant status, endoplasmic reticulum (ER) stress and glucose metabolism in fructose-fed streptozotocin-induced diabetic rats

Obafemi, Tajudeen Olabisi; Jaiyesimi, Kikelomo Folake; Olomola, Adenike A.; Olasehinde, Oluwaseun Ruth; Olaoye, Oyindamola A.; Adewumi, Funmilayo Deborah; Afolabi, Blessing A.; Adewale, Olusola Bolaji; Akintayo, Christopher O.; Ojo, Oluwafemi Adeleke

doi:10.1016/j.toxrep.2021.07.011

Cited by 22 publications

(10 citation statements)

References 82 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, metformin can suppress Ang II-induced cardiovascular remodeling by reducing AT 1 R expression in cardiovascular cells 55 . The antioxidant and anti-inflammatory effects of metformin in the present study have been demonstrated by previous observations in fructose-fed streptozotocin-induced diabetic rats 56 . Metformin has also been shown to enhance PPARγ expression in MS rats 54 and activate the Nrf2/HO-1 signaling pathway to alleviate oxidative stress in type 2 diabetic osteoporosis 57 .…”

Section: Discussionsupporting

confidence: 86%

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Maneesai

Potue

Khamseekaew

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for the last four weeks. TPH had the following effects: resolved their impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, and hypertension (p < 0.05); alleviated left ventricular dysfunction and hypertrophy (p < 0.05), and vascular dysfunction and hypertrophy (p < 0.05); adipocyte hypertrophy; increases in circulating leptin and tumor necrosis factor (TNF-α) were mitigated (p < 0.05); increased renin-angiotensin system (RAS), oxidative stress, and decreased nitric oxide metabolites were modulated (p < 0.05). TPH restored the expression of angiotensin II receptor type 1 (AT1R)/NADPH oxidase 2 (NOX2), endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1), and peroxisome proliferator-activated receptor γ (PPARγ)/the nuclear factor kappa B (NF-κB) protein in cardiovascular tissue (p < 0.05). In metabolic syndrome (MS) rats, metformin and TPH had comparable effects. In conclusion, TPH alleviated cardiovascular complications related to MS. It suppressed RAS, oxidative stress, and inflammation that were associated with modulation of AT1R/NOX2, eNOS, Nrf2/HO-1, and PPARγ/NF-κB expression.

show abstract

Section: Discussionsupporting

confidence: 86%

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Maneesai

Potue

Khamseekaew

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The pancreas and liver of diabetic rats were examined after administering metformin and GA. Outcomes showed that metformin and GA decreased the levels of IL-6 and TNF-α, and the expression of ATF4. Results of the study validated that the combination of GA and metformin is more effective than metformin alone [ 119 ]. Furthermore, another study validated that andrographolide and gallic acid synergistically reduce the level of blood glucose [ 120 ].…”

Section: Pharmacological Efficacy Of Tamarix Aphyllamentioning

confidence: 93%

Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review

Alshehri

Wahab

Abullais

et al. 2021

Plants

View full text Add to dashboard Cite

Tamarix aphylla is a well-known species of the genus Tamarix. T. aphylla (Tamaricaceae) is a perennial tree in Asia, the Middle East, and Central Africa. It is used as a carminative diuretic in tuberculosis, leprosy, and hepatitis. Various pharmacological properties have been shown by T. aphylla, such as antidiabetic, anti-inflammatory, antibacterial, antifungal, anticholinesterase, and wound-healing activity. However, T. aphylla has not received much attention for its secondary metabolites and bioactive constituents. Research has shown that this plant has hidden potential that needs to be explored. This review aims to cover botanical classification, geographical distribution, taxonomy, ethnobotanical uses, and the phytochemical compounds found in T. aphylla. The toxicology and pharmacological effects of T. aphylla are also discussed. We examined various scholarly resources to gather information on T. aphylla, including Google Scholar, Scopus, Science Direct, Springer Link, PubMed, and Web of Science. The finding of this work validates a connection between T. aphylla in conventional medicine and its antidiabetic, antibacterial, anti-inflammatory, wound-healing, antifungal, anticholinesterase, and other biological effects. T. aphylla’s entire plant (such as bark, leaves, fruits) and root extracts have been used to treat hypertension, stomach discomfort, hair loss, cough and asthma, abscesses, wounds, rheumatism, jaundice, fever, tuberculosis, and gum and tooth infection. The phytochemical screening revealed that noticeably all extracts were devoid of alkaloids, followed by the presence of tannins. In addition, different parts have revealed the existence of steroids, flavonoids, cardiac glycosides, and byproducts of gallic acid and ellagic acid. T. aphylla has shown many valuable activities against different diseases and supports its traditional uses. Therefore, high-quality preclinical research and well-designated clinical trials are needed to establish the efficacy and safety of this plant in humans.

show abstract

“…Substantially reduced blood triglycerides have also been reported in diabetic rats [111,122,123,132]. In addition, enhanced antioxidant capacity in liver, pancreas [119,123], blood [125], and brain [126] have been observed. It is of importance to note that phenolic compounds also ameliorated diabetic nephropathy [111] and cognitive decline [112,127].…”

Section: Intracellular Metabolites and Biomarkers Altered In Response...mentioning

confidence: 99%

“…It is of importance to note that phenolic compounds also ameliorated diabetic nephropathy [111] and cognitive decline [112,127]. Importantly, phenolic acids and flavonoids lowered levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in liver, pancreas [119], and brain [126,127], suggesting their importance in the control of inflammation. These mechanisms played important roles in increasing insulin sensitivity and reversing insulin resistance, ameliorating the diabetes condition and related complications.…”

Section: Intracellular Metabolites and Biomarkers Altered In Response...mentioning

confidence: 99%

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

et al. 2022

View full text Add to dashboard Cite

Research in pharmacological therapy has led to the availability of many antidiabetic agents. New recommendations for precision medicine and particularly precision nutrition may greatly contribute to the control and especially to the prevention of diabetes. This scenario greatly encourages the search for novel non-pharmaceutical molecules. In line with this, the daily and long-term consumption of diets rich in phenolic compounds, together with a healthy lifestyle, may have a protective role against the development of type 2 diabetes. In the framework of the described studies, there is clear evidence that the bio accessibility, bioavailability, and the gut microbiota are indeed affected by: the way phenolic compounds are consumed (acutely or chronically; as pure compounds, extracts, or in-side a whole meal) and the amount and the type of phenolic compounds (ex-tractable or non-extractable/macromolecular antioxidants, including non-bioavailable polyphenols and plant matrix complexed structures). In this review, we report possible effects of important, commonly consumed, phenolic-based nutraceuticals in pre-clinical and clinical diabetes studies. We highlight their mechanisms of action and their potential effects in health promotion. Translation of this nutraceutical-based approach still requires more and larger clinical trials for better elucidation of the mechanism of action toward clinical applications.

show abstract

Combined effect of metformin and gallic acid on inflammation, antioxidant status, endoplasmic reticulum (ER) stress and glucose metabolism in fructose-fed streptozotocin-induced diabetic rats

Abstract: Graphical abstract

Cited by 22 publications

References 82 publications

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

Contact Info

Product

Resources

About