Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats

Göker, Funda; Ersanlı, Selim; Arısan, Volkan; Cevher, Erdal; Güzel, Emine; İşsever, Halim; Ömer, Beyhan; Altun, Gülay Durmuş; Morina, Deniz; Yılmaz, Tuğba Ekiz; Dervisoglu, Elmire; Fabbro, Massimo Del

doi:10.1111/odi.12895

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…Chitosan microparticles encapsulating PTH were compressed into tablet implants consisting of strontium and poloxamer. PTH+SR implants showed statistically greater new bone formation in calvarial defects than either treatment alone at both 4 weeks and 8 weeks [303]. The study also reported similar quantities of new bone formation using PTH implants alone and Sr implants alone.…”

Section: Strontiumsupporting

confidence: 60%

Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Simpson

Kelly

Murphy

2020

Advanced Drug Delivery Reviews

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Section: Strontiumsupporting

confidence: 60%

Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Simpson

Kelly

Murphy

2020

Advanced Drug Delivery Reviews

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“…It is biocompatibile, antibacterial and its production is easy. Various studies have tested chitosan as a factor and/or drug delivery system for pharmaceutical and tissue engineering applications [5,17].…”

Section: • Gelatinmentioning

confidence: 99%

“…Owing to the drawbacks and limitations of bone grafts, over the last few decades, several novel approaches involving tissue engineering and regenerative medicine (TE/RM) have emerged as alternatives to conventional treatments. The fundamental concept underlying TE/RM was to use scaffolds alone or in combination with growth factor, cell and/or gene delivery to form a so-called "tissue engineering construct," that stimulates tissue repair and/or regeneration [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology Scaffolds for Alveolar Bone Regeneration

et al. 2020

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In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells. Due to their excellent physicochemical properties and biomimetic features, nanomaterials are attractive alternatives offering many advantages for stimulating cell growth and promoting tissue regeneration through tissue engineering. The main aim of this article was to review the currently available literature to provide an overview of the different nano-scale scaffolds as key factors of tissue engineering for alveolar bone regeneration procedures. In this narrative review, PubMed, Medline, Scopus and Cochrane electronic databases were searched using key words like “tissue engineering”, “regenerative medicine”, “alveolar bone defects”, “alveolar bone regeneration”, “nanomaterials”, “scaffolds”, “nanospheres” and “nanofibrous scaffolds”. No limitation regarding language, publication date and study design was set. Hand-searching of the reference list of identified articles was also undertaken. The aim of this article was to give a brief introduction to review the role of different nanoscaffolds for bone regeneration and the main focus was set to underline their role for alveolar bone regeneration procedures.

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“…Göker et al. (2018) showed that combining PTH with strontium ranelate significantly increased new bone formation and improved osseointegration in ovariectomized rats. Osteoblasts transfected with miR‐185 mimics or siRNA against PTH could decrease the levels of PTH, Wnt, and β‐catenin.…”

Section: Figurementioning

confidence: 99%

Possible mechanism of combining hyperbaric oxygen with parathyroid hormone to promote bone regeneration

et al. 2020

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We read with great interest the paper published in your journal (Park et al., 2019). The authors highlighted that hyperbaric oxygen (HBO) combined with parathyroid hormone (PTH) could significantly increase the volume of new bone and decrease the residual material volume, thus reversing the radiation-induced bone-healing impairment. However, the mechanism behind the combined effects of HBO and PTH on bone regeneration following radiation exposure was not explored by Park et al. Therefore, this letter to the editor aims at discussing some of the mechanisms that may be playing a role in the healing process mediated by the synergistic effect of HBO and PTH. Animal experiments have showed that HBO could stimulate vascularization and new bone formation in rat calvarial defects and enhance the number of CD31-positive cells and its expression levels. Furthermore, HBO could also upregulate osteogenic marker gene expression and downregulate pro-inflammatory cytokine expression (Pedersen, Xing, Finne-Wistrand, Hellem,

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Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats

Abstract: Parathyroid hormone and SR combinations can be effective for calvarial bone regeneration of ovariectomized rats. PTH plus SR may have potential use as bone graft material in orthopedic and dental surgery to enhance bone healing and osseointegration.

Cited by 7 publications

References 62 publications

Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Nanotechnology Scaffolds for Alveolar Bone Regeneration

Possible mechanism of combining hyperbaric oxygen with parathyroid hormone to promote bone regeneration

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