Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages

Teselkin, Yu. O.; Хорева, М. В.; Veselova, A V; Babenkova, I. V.; Осипов, А. Н.; Gankovskaya, L. V.; Vladimirov, Yu. A.

doi:10.1007/s10517-018-4281-9

Cited by 2 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, the slides were rinsed with saline, air-dried, fixed in 1:1 acetone/methanol solution, stained in 4% Giemsa-phosphate buffer dye for 3 min, rinsed again with distilled water and dried. Under the microscopic oil lens, 100 macrophages were counted and used to calculate the phagocytic rate and phagocytic index as described [19].…”

Section: Peritoneal Macrophage Phagocytosis Of the Chicken Red Blood Cells Testmentioning

confidence: 99%

Study on the Enhancement of Immune Function of Astaxanthin from Haematococcus pluvialis

Fan

Chen

et al. 2021

Foods

View full text Add to dashboard Cite

This study was aimed at investigating the effect of astaxanthin on the immune function and its safety in mice. It was administered once daily at low, medium and high doses (4.2, 8.35, 16.70 mg/kg BW) to mice for 30 days. Subsequently, the spleen and thymus index, spleen lymphocyte transformation activity, delayed allergy reaction, amounts of antibody-producing cells, half-hemolytic value HC50, carbon particle clearance rate, macrophage phagocytosis, and natural killer cell (NK) activity were determined. Acute oral toxicity and genotoxicity tests were conducted to evaluate the safety of astaxanthin. Compared with the control group, medium and high doses of astaxanthin significantly increased the proliferation and transformation activities of spleen lymphocytes, activities of antibody-producing cells, serum hemolysin levels, and carbon particle clearance rate in mice (phagocytic index). High doses significantly improved delayed allergy reaction and NK cell activity. Results of acute oral toxicity and genotoxicity tests were negative. Gross anatomical observations and histopathological examination showed no abnormal changes associated with the treatments. In the article, it is confirmed that astaxanthin treatments significantly improve immune functions and show no toxic effects in the experimental doses.

show abstract

Section: Peritoneal Macrophage Phagocytosis Of the Chicken Red Blood Cells Testmentioning

confidence: 99%

Study on the Enhancement of Immune Function of Astaxanthin from Haematococcus pluvialis

Fan

Chen

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

TLR2 reprograms glucose metabolism in CD4+ T cells of rheumatoid arthritis patients to mediate cell hyperactivation and TNF-α secretion

Lin,

Zhang,

Huang

et al. 2024

Clin Rheumatol

View full text Add to dashboard Cite

Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages

Cited by 2 publications

References 14 publications

Study on the Enhancement of Immune Function of Astaxanthin from Haematococcus pluvialis

Study on the Enhancement of Immune Function of Astaxanthin from Haematococcus pluvialis

TLR2 reprograms glucose metabolism in CD4+ T cells of rheumatoid arthritis patients to mediate cell hyperactivation and TNF-α secretion

Contact Info

Product

Resources

About