Combined effect of vanadium and zinc on certain selected haematological indices in rats

Zaporowska, Halina; Wasilewski, Wacław

doi:10.1016/0742-8413(92)90243-z

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…In contrast, Bonham et al (2003) stated that daily 40 mg Zn supplementation to the diet does not influence the blood parameters. In another investigation with 2-month-old rats, supplementation of 12 mg Zn kg -1 diet decreased the hemoglobin 85% compared to the control animals (Zaporowska and Wasilewski 1992). Current results are similar by those of Do Carmo et al (2004) that established an increase in hematocrit with augmentation of dietary Zn level reaching to the 27.67 ± 0.76%, which show their higher capability of oxygen transfer from the gills to the tissues as well as more blood rheology and hemodynamics.…”

Section: Discussionmentioning

confidence: 99%

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

et al. 2017

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This study investigated the effect of dietary Zn levels on growth performance, feed utilization, and hematological parameters of juvenile Siberian sturgeon (Acipenser baerii, Brandt 1869). The five semipurified diets were formulated by adding 0, 5, 10, 20, and 40 mg Zn kg -1 diet in the form of zinc sulfate (ZnSO 4 ) to provide the actual dietary value of 14.7, 20.8, 27.3, 37.7, and 46.4 Zn kg -1 diet, respectively. The results showed that dietary Zn elevating level significantly improved the growth and feed utilization of the fish (p \ 0.05), but not the hepatosomatic index (p [ 0.05). Erythrocyte number, hemoglobin concentration, and hematocrit were increased with raising dietary Zn level (p \ 0.05), whereas a regular trend was not observed in blood indices, including MCV, MCH, and MCHC. A significant increase was also found in the leucocyte number followed by their differential counts, except for eosinophil percentage. The broken line regression model indicated optimal dietary Zn level for growth maximization of fish was estimated to be 29.15 mg Zn kg -1 diet. In spite of well correlation with dietary Zn level, no break point was observed to estimate the juvenile Siberian sturgeon requirement based on the erythrocyte numbers.

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Section: Discussionmentioning

confidence: 99%

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

et al. 2017

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“…In rats, the lowest LOAEL for hematological effects was 4 mg/kg per day (8 mg/kg every other day) for an increased frequency of basophilic-stippled erythrocytes in rats exposed every other day for 14 days (Piao et al, 2003). The s lowest LOAEL is 12 mg zinc/kg per day as zinc chloride in a four-week drinking water study with two-month-old rats (Zaporowska and Wasilewski, 1992) that reported decreased hemoglobin (85% of control values) and erythrocytes (90% of control values). The highest NOAEL in rats is 191 mg zinc/kg per day as zinc acetate in a three-month drinking water study (age of rats not specified) (Llobet et al, 1988a).…”

Section: Hematological Effectsmentioning

confidence: 95%

ATSDR evaluation of the health effects of zinc and relevance to public health

et al. 2006

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As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites, which have the greatest public health impact. These profiles comprehensively summarise toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Zinc. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of zinc. It contains descriptions and evaluations of toxicological studies and epidemiological investigations, and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health.

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“…The NOAEL dose has been established at 0.2 mg of vanadium/kg/day for an acuteduration oral MRL. Long-term vanadium treatments observed significant decreases in erythrocyte counts in rats exposed to 1.18 mg vanadium/kg/day in the form of ammonium metavanadate in drinking water during 4 weeks [32] and a decrease in hemoglobin which is compensated with reticulocyte increase in peripheral blood [32,[48][49][50][51][52][53]. However, previous intermediate-duration studies did not found significant alterations in doses up to of 9.7 mg vanadium/kg/day [36,37].…”

Section: Vanadium Entrance Via Digestive Systemmentioning

confidence: 99%

Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus

Treviño

Díaz

Sánchez-Lara

et al. 2018

Biol Trace Elem Res

252

126

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Vanadium compounds have been primarily investigated as potential therapeutic agents for the treatment of various major health issues, including cancer, atherosclerosis, and diabetes. The translation of vanadium-based compounds into clinical trials and ultimately into disease treatments remains hampered by the absence of a basic pharmacological and metabolic comprehension of such compounds. In this review, we examine the development of vanadium-containing compounds in biological systems regarding the role of the physiological environment, dosage, intracellular interactions, metabolic transformations, modulation of signaling pathways, toxicology, and transport and tissue distribution as well as therapeutic implications. From our point of view, the toxicological and pharmacological aspects in animal models and humans are not understood completely, and thus, we introduced them in a physiological environment and dosage context. Different transport proteins in blood plasma and mechanistic transport determinants are discussed. Furthermore, an overview of different vanadium species and the role of physiological factors (i.e., pH, redox conditions, concentration, and so on) are considered. Mechanistic specifications about different signaling pathways are discussed, particularly the phosphatases and kinases that are modulated dynamically by vanadium compounds because until now, the focus only has been on protein tyrosine phosphatase 1B as a vanadium target. Particular emphasis is laid on the therapeutic ability of vanadium-based compounds and their role for the treatment of diabetes mellitus, specifically on that of vanadate-and polioxovanadate-containing compounds. We aim at shedding light on the prevailing gaps between primary scientific data and information from animal models and human studies.

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Combined effect of vanadium and zinc on certain selected haematological indices in rats

Cited by 12 publications

References 27 publications

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

ATSDR evaluation of the health effects of zinc and relevance to public health

Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus

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