Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats

Abstract

Combination of sivelestat and edaravone shows promise as a new treatment option for ALI/acute respiratory distress syndrome patients.

Edaravone protects rats and human pulmonary alveolar epithelial cells against hyperoxia injury: heme oxygenase-1 and PI3K/Akt pathway may be involved

“…Secondly, as it has been clinically used for many years, its safety has been well proven. Thirdly, many studies have demonstrated the effects of edaravone against lung injuries, such as hepatic ischemia-reperfusion-induced lung injury, black gunpowder smog-induced lung injury induced, lipopolysaccharide-induced acute lung injury, paraquat-induced lung injury [47][48][49][50]. Taken together, these results indicate the potential benefit of edaravone in various lung injuries due to oxidative stress besides hyperoxia.…”

Friend or foe? The dual role of neutrophils in lung injury and repair

“…Sivelestat, a small molecular weight inhibitor of neutrophil elastase, has been associated with a reduction in clinical features and improved survival in a number of animal models of ALI (eg, ref 4). This protective effect was enhanced when Sivelestat was given with edaravone (a free radical scavenger),5 targeting neutrophilic products by combining an antiproteinase with an antioxidant. Together, these data suggest that neutrophils are injurious in ALI, and may form a therapeutic target to improve outcomes.…”

A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation

“…35 Among cytokines, the secretion of proinflammatory cytokines, such as TNF-a, IL-1b, and IL-6, is especially strongly enhanced by LPS stimulation. 36,37 In the present study, although urushiol was removed, our standardized RVS extract prevented inflammatory stimulation by LPS, as confirmed by hepatic iNOS and COX-2 mRNA expression and proinflammatory cytokine secretion levels (TNF-a, IL-1b, and IL-6). In addition, inflammatory cell infiltration was significantly attenuated by RVS extract supplementation.…”