A Standardized Extract of <i>Rhus verniciflua</i> Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation

Moon, Ji Eun; Shin, Jae Ho; Kwon, Oran; Kim, Ji Yeon

doi:10.1089/jmf.2014.3411

Cited by 17 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several animal studies have reported that R. verniciflua exerted beneficial effects on inflammation and several metabolic diseases [ 16 , 17 ] and protective effects against drug toxicity [ 18 ]. The previous studies suggested that R. verniciflua would be a potent candidate for drug development to treat chemotherapy-induced side effects, particularly emesis.…”

Section: Introductionmentioning

confidence: 99%

Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin‐Induced Rat Model

Kim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Rhus verniciflua Stoke has been commonly used in traditional medicine to treat gastrointestinal (GI) dysfunction diseases. In order to investigate pharmacological properties of Rhus verniciflua Stoke water extract (RVX) on cisplatin-induced amnesia, RVX (0, 25, 50, or 100 mg/kg) was orally administrated for five consecutive days after a single intraperitoneal injection of cisplatin (6 mg/kg) to SD rat. Cisplatin injection significantly increased the kaolin intake (emesis) but reduced the normal diet intake (anorexia) whereas the RVX treatment significantly improved these abnormal diet behaviors at both the acute and delayed phase. The serotonin concentration and the related gene expressions (5-HT3 receptors and SERT) in small intestine tissue were abnormally altered by cisplatin injection, which were significantly attenuated by the RVX treatment. Histological findings of gastrointestinal tracts, as well as the proteins level of proinflammatory cytokines (TNF-α, IL-6, and IL-1β), revealed the beneficial effect of RVX on cisplatin-induced gastrointestinal inflammation. In addition, RVX significantly improved cisplatin-induced myelosuppression, as evidenced by the observation of leukopenia and by histological examinations in bone marrow. Our findings collectively indicated Rhus verniciflua Stoke improved the resistance of rats to chemotherapy-related adverse effects in the gastrointestinal track and bone marrow.

show abstract

Section: Introductionmentioning

confidence: 99%

Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin‐Induced Rat Model

Kim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…A similar study in which rats were orally given RVS extract at 100 mg/kg and 500 mg/kg for 2 weeks and then challenged with intraperitoneal LPS showed a significant reduction in IL-6 protein and a marginal reduction in TNF- protein in the liver [36]. These hepatic cytokine concentrations were measured 16 h after LPS stimulation [36]. However, the peak response of serum TNF- is approximately 1 h after intraperitoneal challenge with LPS and rapidly declines [31].…”

Section: Rvs Extract Suppressed the Systemic Response To Lpsmentioning

confidence: 80%

“…This is likely due to the fact that macrophages are continuously exposed to LPS in vitro, but LPS is rapidly cleared by the liver in vivo [35]. A similar study in which rats were orally given RVS extract at 100 mg/kg and 500 mg/kg for 2 weeks and then challenged with intraperitoneal LPS showed a significant reduction in IL-6 protein and a marginal reduction in TNF- protein in the liver [36]. These hepatic cytokine concentrations were measured 16 h after LPS stimulation [36].…”

Section: Rvs Extract Suppressed the Systemic Response To Lpsmentioning

confidence: 99%

Macrophages from Mice Administered <em>Rhus Verniciflua</em> Stokes Extract Show Selective Anti-Inflammatory Activity

Kim¹,

Song²,

Lee³

et al. 2018

Preprint

View full text Add to dashboard Cite

The bark of Rhus verniciflua Stokes (RVS) is used as a food additive and herbal medicine for various inflammatory disorders and cancer in Eastern Asia. RVS exerted anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, but whether this effect occurs in macrophages after oral administration has not been determined. We used a thioglycollate-induced peritonitis model to obtain macrophages from mice given RVS. We examined the systemic inflammatory response to intraperitoneal LPS. RVS-treated mice had an increased population of peritoneal exudate cells expressing CD11b and SRA. Increased uptake of Alexa Fluor 488-labeled acetylated lipoprotein was observed in monocyte-derived macrophages from RVS-treated mice. When these cells from the RVS group were stimulated with LPS, the levels of tumor necrosis factor (TNF)- and interleukin (IL)-6 in the supernatant decreased, but the level of IL-12 increased. The surface expression of CD86 was reduced, but surface expression of class II MHC molecules was increased. RVS suppressed the serum levels of LPS-induced TNF- and IL-6. RVS enhanced monocyte differentiation in thioglycollate-induced peritonitis by increasing scavenger receptor expression and activity. Macrophages isolated from mice given RVS responded differently to LPS. These findings demonstrate that RVS confers selective anti-inflammatory activity without causing the overall inhibitory effects on immune cells.

show abstract

“…This is likely due to the fact that macrophages are continuously exposed to LPS in vitro, but LPS is rapidly cleared by the liver in vivo [35]. A similar study in which rats were orally given RVS extract at 100 mg/kg and 500 mg/kg for 2 weeks and then challenged with intraperitoneal LPS showed a significant reduction in IL-6 protein and a marginal reduction in TNF-α protein in the liver [36]. These hepatic cytokine concentrations were measured 16 h after LPS stimulation [36].…”

Section: Discussionmentioning

confidence: 99%

Macrophages from Mice Administered Rhus verniciflua Stokes Extract Show Selective Anti-Inflammatory Activity

et al. 2018

View full text Add to dashboard Cite

The bark of Rhus verniciflua Stokes (RVS) is used as a food additive and herbal medicine for various inflammatory disorders and cancer in Eastern Asia. RVS has been shown to exert anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated macrophages in vitro, but whether oral administration of RVS affects the inflammatory response of macrophage needs to be verified. RVS was given orally to mice for ten days. For isolation of macrophages, intraperitoneal injection of thioglycollate was performed. For determination of serum inflammatory response, intraperitoneal injection of LPS was applied. RVS stimulated monocyte differentiation in thioglycollate-induced peritonitis by increasing the population of cells expressing CD11b and class A scavenger receptors. These monocyte-derived macrophages showed an increased uptake of acetylated low-density lipoprotein. When peritoneal macrophages from the RVS group were stimulated with LPS, the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in the supernatant decreased, but the level of IL-12 increased. The surface expression of CD86 was reduced, but surface expression of class II major histocompatibility complex molecules was increased. RVS suppressed the serum levels of LPS-induced TNF-α and IL-6. Collectively, RVS promoted monocyte differentiation upon inflammatory insults and conferred selective anti-inflammatory activity without causing overall inhibitory effects on immune cells.

show abstract

A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation

Cited by 17 publications

References 41 publications

Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin‐Induced Rat Model

Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin‐Induced Rat Model

Macrophages from Mice Administered <em>Rhus Verniciflua</em> Stokes Extract Show Selective Anti-Inflammatory Activity

Macrophages from Mice Administered Rhus verniciflua Stokes Extract Show Selective Anti-Inflammatory Activity

Contact Info

Product

Resources

About