Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Ćurčić, Marijana; Janković, Saša; Jacević, Vesna; Stankovic, S.; Vučinić, Slavica; Durgo, Ksenija; Bulat, Zorica; Antonijević, Biljana

doi:10.2478/10004-1254-63-2012-2179

Cited by 30 publications

(11 citation statements)

References 38 publications

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“…There are also examples of a significant association between Cd and myocardial infarction (2) as well as between Cd and prediabetes and diabetes mellitus in humans (3). Furthermore, cadmium acts as an inorganic xenoestrogen in humans: there is evidence that Cd possesses estrogenic activity (4,5), while its thyroid-disrupting activities have been observed in experimental studies (6)(7)(8).…”

mentioning

confidence: 99%

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg -1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg -1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO 3 ) and perchloric acid (HClO 4 ) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

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mentioning

confidence: 99%

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…U novijoj luteraturi se može naći i određen broj radova koji se bave ispitivanjem dvokomponentnih smeša, i to ispitivanjem toksičnosti smeša koje sadrže dva predstavnika jedne grupe hemikalija, kao što su na primer metali (18,19), ali i ispitivanja smeša koje sadrže komponente različitih toksikokinetičkih i toksikodinamičkih osobina, često sa ciljem definisanja međusobnih efekata komponenata, prisustva i tipa interakcija među komponentama na mestima toksičnog dejstva smeša (20,21,22,23).…”

Section: Aktuelna Istraživanja U Oblasti Toksikologije Smešeunclassified

Basic principles of toxicological evaluation of mixtures

Buha¹,

Matović²

2015

Arh farmaciju

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Većina toksikoloških studija i evaluacija rizika odnose se na pojedinačne hemikalije. Međutim, u realnom okruženju izloženi smo istovremeno velikom broju hemikalija, što ukazuje da bi pri proceni izloženosti i rizika trebalo posmatrati smeše, a ne samo pojedinačne hemikalije. Ovaj pregledni rad o toksikologiji hemijskih smeša pokriva više stavki, od osnovnih koncepata i terminologije zajedničkog dejstva i interakcija hemikalija do različitih modela za ispitivanje toksičnosti smeša. Literaturni podaci ukazuju na činjenicu da izloženost smešama koje sadrže niske nivoe hemikalija, nivoe koji su niži od njihovih doza bez štetnog efekta (No observed adverse effect level -NOAEL) vrednosti, može rezultirati toksičnim odgovorom bez obzira da li komponente smeše imaju ili ne sličan način dejstva. Dati su i različiti pristupi i primeri koncepata i modela procene toksičnosti prioritetnih smeša iz realnog života, strategija i smernice, kao i dalji izazovi.Ključne reči: smeše, toksičnost, koncepti i modeli, interakcije komponenata

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“…These criteria can be applied broadly to interaction studies for drugs, pesticides, industrial chemicals, food additives, and natural products, although compliance with them does not necessarily render the results of an interaction study suitable for every purpose or every risk assessment. The focus on chemical interaction, particularly at environmentally relevant concentrations, using valid toxicological and statistical tests, has been reported in a few experimental studies (Ćurčić et al 2012;Buha et al 2013;Zhu et al 2014;Chen et al 2016;Curcic et al 2017) and represents an important step toward advancing human and environmental risk assessments for chemical mixtures.…”

Section: Introduction To Chemical Mixturesmentioning

confidence: 99%

Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures

et al. 2019

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Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the organism. The need for adequate model systems (in vivo, in vitro, in silico and mathematical) is paramount for better understanding of chemical mixture toxicity. Currently, shortcomings plague each model system as investigators struggle to find the appropriate balance of rigor, reproducibility and appropriateness in mixture toxicity studies. Significant questions exist when comparing single-to mixture-chemical toxicity concerning additivity, synergism, potentiation, or antagonism. Dose/concentration relevance is a major consideration and should be subthreshold for better accuracy in toxicity assessment. Previous work was limited by the technology and methodology of the time, but recent advances have resulted in significant progress in the study of mixture toxicology. Novel technologies have added insight to data obtained from in vivo studies for predictive toxicity testing. These include new in vitro models: omics-related tools, organs-on-a-chip and 3D cell culture, and in silico methods. Taken together, all these modern methodologies improve the understanding of the multiple toxicity pathways associated with adverse outcomes (e.g., adverse outcome pathways), thus allowing investigators to better predict risks linked to exposure to chemical mixtures. As technology and knowledge advance, our ability to harness and integrate separate streams of evidence regarding outcomes associated with chemical mixture exposure improves. As many national and international organizations are currently stressing, studies on chemical mixture toxicity are of primary importance.

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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Cited by 30 publications

References 38 publications

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Basic principles of toxicological evaluation of mixtures

Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures

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