Combined Effects of Noise and Kanamycin: Cochlear Pathology and Pharmacology

Brown, Jeffrey J.; Brummett, Robert E.; Fox, Kaye E.; Bendrick, Thomas W.

doi:10.1001/archotol.1980.00790360022008

Cited by 42 publications

(17 citation statements)

References 18 publications

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“…We know of no other study demonstrating a protective effect of kanamycin or any other ototoxin against NIPTS. Instead, many studies have shown exacerbation of NIPTS by aminoglycosides in animals (e.g., Bombard et al 2005;Dayal et al 1971;Dayal and Barek 1975;Marques et al 1975;Hawkins et al 1975;Ryan and Bone 1978;Brown et al 1980;Brummett et al 1992). This effect has, therefore, been predicted for humans and anticipated to be enhanced in human infants (see Li and Steyger 2009).…”

Section: Kanamycin In the Early Vulnerability Windowmentioning

confidence: 99%

“…Thus, no special susceptibility of any single structure or cell type can provide a complete explanation. Animal studies also support synergistic interaction between noise and ototoxins, at least in adults (e.g., Dayal et al 1971;Dayal and Barek 1975;Marques et al 1975;Hawkins et al 1975;Ryan and Bone 1978;Brown et al 1980;Brummett et al 1992). Most of these applied high levels of noise and ototoxins.…”

Section: Introductionmentioning

confidence: 96%

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Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Fernandez

Ohlemiller

Gagnon

et al. 2010

JARO

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Animal studies indicate that a combination of kanamycin (KM) and noise produces a synergistic effect, whereby the threshold shift from the combination is greater than the sum of the shifts caused by either agent alone. Most such studies have focused on adult animals, and it has remained unclear whether younger, presumably more susceptible, animals show an even greater synergistic effect. The present study tested the hypothesis that young CBA/J mice receiving a low dose of KM (300 mg/kg, 2×/day, s.c.) from 20 to 30 days post-gestational age followed by brief noise exposure (110 dB SPL; 4-45 kHz, 30 s) would show greater noise-induced permanent threshold shifts (NIPTS) than mice receiving either treatment alone. Noise exposure produced 30-40 dB of NIPTS and moderate hair cell loss in young saline-treated mice. KM alone at this dose had no effect on thresholds. Surprisingly, mice receiving KM plus noise were protected from NIPTS, showing ABR thresholds not significantly different from unexposed controls. Mice receiving KM prior to noise exposure also showed significantly less outer hair cell loss than saline-treated mice. Additional experiments indicated protection by KM when the noise was applied either 24 or 48 h after the last KM injection. Our results demonstrate a powerful protective effect of subchronic low-dose kanamycin against NIPTS in young CBA/J mice. Repeated kanamycin exposure may establish a preconditioned protective state, the molecular bases of which remain to be determined.

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Section: Kanamycin In the Early Vulnerability Windowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Fernandez

Ohlemiller

Gagnon

et al. 2010

JARO

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“…Today several environmental factors are known to cause an increased risk of hearing loss. They include coexposure to noise and chemicals (organic solvents, heavy metals) (Sliwinska-Kowalska et al, 2005), ototoxic agents (aminoglycosides) (Dayal et al, 1971;Brown et al, 1980;Dodson et al, 1982), heat (Pekkarinen, 1995), noise impulsiveness and vibrations . Associations have also been observed between several individual factors and NIHL, including smoking (Nomura et al, 2005), elevated blood pressure (Starck et al, 1999), cholesterol levels (Toppila et al, 2001), skin pigmentation (Barrenäs, 1998), gender (Berger et al, 1978) and age (for a review see Borg et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Gene Polymorphisms Associated with K⁺ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise‐induced Hearing Loss

Pawełczyk

Laer

Fransén

et al. 2009

Annals of Human Genetics

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SummaryNoise-induced hearing loss (NIHL) is one of the leading occupational health risks in industrialized countries. It results from an interaction between environmental and genetic factors, however the nature of the genetic factors contributing to NIHL has not yet been clarified. Here, we investigated whether genetic variations in 10 genes putatively involved in the potassium recycling pathway in the inner ear may influence susceptibility to noise. 99 SNPs were genotyped in Polish noise-exposed workers, categorized into susceptible and resistant subjects. The most interesting results were obtained for KCNE1 and KCNQ4 as we replicated associations that were previously reported in a Swedish sample set, hence confirming that they are NIHL susceptibility genes. Additionally we report significant associations in GJB1, GJB2, GJB4, KCNJ10 and KCNQ1, however due to the lack of replication in the Swedish sample set, these results should be seen as suggestive.

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“…impulsowość hałasu (hałas impulsowy jest bardziej szkodliwy niż hałas ustalony lub nieustalony o takim samym równoważnym poziomie dźwięku A), czas i rodzaj ekspozycji (przerwy w narażeniu umożliwiają regenerację narządu słuchu), równoczesną ekspozycję na niektóre substancje chemiczne (w tym rozpuszczalniki organiczne i metale ciężkie) lub drgania mechaniczne, a także leki ototoksyczne (aminoglikozydy), hipertermię oraz palenie papierosów [2][3][4][5][6][7][8][9]. Czynniki wewnątrzpochodne to przede wszystkim choroby metaboliczne (hiperlipidemia i cukrzyca), nadciśnienie tęt-nicze krwi, występowanie objawu Reynauda (blednię-cia palców) i jasna karnacja skóry [10][11][12].…”

Section: Wstępunclassified

Do hearing threshold levels in workers of the furniture industry reflect their exposure to noise?

Pawlaczyk-Łuszczyńska¹,

Dudarewicz²,

Czaja³

et al. 2016

Med Pr

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StreszczenieWstęp: Celem pracy była analiza stanu słuchu pracowników zakładu meblarskiego z uwzględnieniem ich narażenia zawodowego na hałas i występowania dodatkowych czynników ryzyka uszkodzenia słuchu spowodowanego hałasem. Materiał i metody: W grupie 50 mężczyzn w wieku 20-57 lat, zatrudnionych bezpośrednio przy produkcji mebli, przeprowadzono pomiary hała-su, badania kwestionariuszowe i ocenę stanu słuchu z zastosowaniem audiometrii tonalnej. Rzeczywiste progi słuchu pracowników porównano z progami przewidywanymi, wyznaczonymi według normy PN-ISO 1999:2000 na podstawie ich wieku, płci i narażenia na hałas. Wyniki: Badane osoby pracowały przez 3-14 lat w warunkach narażenia na hałas o jego dziennym poziomie ekspozycji 82,7-94,8 dB (średnia: 90,9 dB). U wszystkich osób średni próg słuchu dla częstotliwości 500 Hz, 1000 Hz, 2000 Hz i 4000 Hz nie przekraczał 25 dB, ale w przypadku 11% audiogramów zaobserwowano załamki wysokoczęstotliwościowe, typowe dla działania hałasu. Rzeczywiste progi słuchu pracowników w zakresie częstotliwości 3000-6000 Hz były zbliżone do przewidywanych według PN-ISO 1999:2000. Stwierdzono istotnie statystyczne różnice między progami słuchu w podgrupach osób z wyż-szym (> 78 mm Hg) i niższym (≤ 78 mm Hg) ciśnieniem rozkurczowym krwi, palących papierosy i niepalących oraz pracujących bez kontaktu lub w kontakcie z rozpuszczalnikami organicznymi. U osób z ww. dodatkowymi czynnikami ryzyka obserwowano większe ubytki słuchu. Wnioski: Wyniki badań potwierdzają, że podczas szacowania ryzyka uszkodzenia słuchu spowodowanego hałasem i opracowywania programów ochrony słuchu pracowników konieczne jest uwzględnianie dodatkowych (poza hała-sem) czynników ryzyka, w tym palenia papierosów, podwyższonego ciśnienia tętniczego krwi i równoczesnej ekspozycji na rozpuszczalniki organiczne. Med. Pr. 2016;67(3):337-351 Słowa kluczowe: ekspozycja zawodowa, hałas, audiometria tonalna, uszkodzenie słuchu spowodowane hałasem, czynniki ryzyka uszkodzenia słuchu, progi słuchu Abstract Background: The aim of the study was to analyze the hearing status of employees of a furniture factory with respect to their exposure to noise and the presence of additional risk factors of noise-induced hearing loss (NIHL). Material and Methods: Noise measurements, questionnaire survey and assessment of hearing, using pure tone audiometry, were carried out in 50 male workers, aged 20-57 years, directly employed in the manufacture of furniture. The actual workers' hearing threshold levels (HTLs) were compared with the predictions calculated according to PN-ISO 1999:2000 based on age, gender and noise exposure. Results: Workers under study were exposed to noise at daily noise exposure levels of 82.7-94.8 dB (mean: 90.9 dB) for a period of 3-14 years. In all subjects, mean HTL at 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz did not exceed 25 dB. Nevertheless, high frequency notches were found in 11% of audiograms. The actual workers' HTLs at 3000-6000 Hz were similar to those predicted using PN-ISO 1999:2000. There were statistical significant...

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Combined Effects of Noise and Kanamycin: Cochlear Pathology and Pharmacology

Cited by 42 publications

References 18 publications

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Analysis of Gene Polymorphisms Associated with K⁺ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise‐induced Hearing Loss

Do hearing threshold levels in workers of the furniture industry reflect their exposure to noise?

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Combined Effects of Noise and Kanamycin: Cochlear Pathology and Pharmacology

Cited by 42 publications

References 18 publications

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Analysis of Gene Polymorphisms Associated with K+ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise‐induced Hearing Loss

Do hearing threshold levels in workers of the furniture industry reflect their exposure to noise?

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Analysis of Gene Polymorphisms Associated with K⁺ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise‐induced Hearing Loss