Combined effects of photobiomodulation and curcumin on mast cells and wound strength in wound healing of streptozotocin-induced diabetes in rats

Soleimani, Hasan; Amini, Abdollah; Abdollahifar, Mohammad‐Amin; Norouzian, Mohsen; Kouhkheil, Reza; Mostafavinia, Atarodsadat; Ghoreishi, Seyed Kamran; Bayat, Sahar; Chien, Sufan; Bayat, Mohammad

doi:10.1007/s10103-020-03053-8

Cited by 10 publications

(3 citation statements)

References 48 publications

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“…Accordingly, since tryptase contributes to the pathogenesis of diabetes and its complexities, aiming MCs as a new remedy for diabetes needs more investigations [12]. In this context, it has been reported that the increased numbers of total MC density and degranulation in diabetic animals negatively affected the potentiometric properties of their skin wounds [13][14][15]. Recently, Wygrecka et al have suggested that MCs might provide to the fibrotic course by encouraging local fibroblasts in the lung, therefore leading to the pathogenesis of the illness [16].…”

Section: Discussionmentioning

confidence: 99%

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Bayat

Chien

Chehelcheraghi

2021

BioMed Research International

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Background. Cardiovascular disease (CVD) contributes critically to the mortality, morbidity, and economic problem of illness globally. Exercise is a share of everyone’s life. Some evidence-based studies have frequently shown a progressive correlation between physical activity and good health. Objective. The effects of daily exercise on cardiomyocyte size, collagen content (fibrosis), and releasing mast cells (MCsʼ) tryptase of the model of myocardial infarction (MI) were assessed. Methods. 40 rats were coincidentally spread into sham+inertia (control), sham+exercise, infarction+inertia, and infarction+exercise groups. An experimental model of acute MI was induced in infarction groups. One week after surgery, exercising groups were allowed to an aerobic exercise program for six weeks. At the endpoint of the study, all examinations were performed. Results. We found lesser fibrosis in sham+exercise and infarction+exercise groups compared to sham+inertia and infarction+inertia groups, respectively ( p = 0.023 , p = 0.001 ). Also, infarction groups were significantly lower than sham groups ( p < 0.05 ) and the infarction+exercise group was significantly lower than the infarction+inertia group ( p < 0.05 ). The effect of exercise on MCs while increased MC density and degranulation occur at the site of fibrosis, we demonstrated that exercise decreases both total MC density and degranulation in both sham and infarction groups ( p < 0.05 ). Immunohistochemistry examinations were significantly higher expression of MCsʼ tryptase in infarction groups than sham groups ( p < 0.05 , p < 0.0001 ). Conclusion. Exercise improves fibrosis and cardiac function in both healthy and MI rats by inhibiting released MCsʼ tryptase.

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Section: Discussionmentioning

confidence: 99%

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Bayat

Chien

Chehelcheraghi

2021

BioMed Research International

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“…Some studies have reported no difference in the total number of MCs between DW and normal wounds, 82 but others have reported an increase in the number of MCs in DW. 92 This discrepancy may be due to the difference in modeling methods or the monitoring time of MCs in DW. Undoubtedly, in DW characterized by a high-glucose microenvironment, the degranulation of MCs increases, and the release of MC-derived VEGF is reduced.…”

Section: Immune Cell Imbalance In the Process Of Dwmentioning

confidence: 99%

“…132 Photobiomodulation significantly decreases the total number of MCs, which improves the healing process in diabetic animals. 92 Different electrical stimulations also promote wound healing by regulating different immune cells. 133 Holsapple JS 134 et al recruited patients with treatment-resistant venous ulceration for two weeks of extracorporeal shockwave therapy (ESWT), and the results showed that ESWT significantly increased the uptake of apoptotic cells, healing-associated cytokine and growth factor gene expression and modulated the macrophage morphology to one suggestive of macrophage activation, all of which contributed to wound resolution.…”

Section: Targeted Immunotherapy For Dwmentioning

confidence: 99%

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Song¹,

Hu²,

Liu³

et al. 2022

JIR

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Poor wound healing in individuals with diabetes has long plagued clinicians, and immune cells play key roles in the inflammation, proliferation and remodeling that occur in wound healing. When skin integrity is damaged, immune cells migrate to the wound bed through the actions of chemokines and jointly restore tissue homeostasis and barrier function by exerting their respective biological functions. An imbalance of immune cells often leads to ineffective and disordered inflammatory responses. Due to the maladjusted microenvironment, the wound is unable to smoothly transition to the proliferation and remodeling stage, causing it to develop into a chronic refractory wound. However, chronic refractory wounds consistently lead to negative outcomes, such as long treatment cycles, high hospitalization rates, high medical costs, high disability rates, high mortality rates, and many adverse consequences. Therefore, strategies that promote the rational distribution and coordinated development of immune cells during wound healing are very important for the treatment of diabetic wounds (DW). Here, we explored the following aspects by performing a literature review: 1) the current situation of DW and an introduction to the biological functions of immune cells; 2) the role of immune cells in DW; and 3) existing (or undeveloped) therapies targeting immune cells to promote wound healing to provide new ideas for basic research, clinical treatment and nursing of DW.

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Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study

et al. 2020

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Combined effects of photobiomodulation and curcumin on mast cells and wound strength in wound healing of streptozotocin-induced diabetes in rats

Cited by 10 publications

References 48 publications

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study

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