Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds

Chereddy, Kiran Kumar; Lopes, Alessandra; Koussoroplis, Salome Juliette; Payen, Valéry L.; Moia, Claudia; Zhu, Huijun; Sonveaux, Pierre; Carmeliet, Peter; Rieux, Anne des; Vandermeulen, Gaëlle; Préat, Véronique

doi:10.1016/j.nano.2015.07.006

Cited by 119 publications

(62 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemistry (CD34+) studies revealed that PLGA NP and PLGA‐VEGF NP treatments significantly promoted angiogenesis and blood capillary infiltration in wound sections than the other groups (Figure A and B). In conclusion, PLGA based VEGF delivery systems can promote wound healing because of its lactate and the encapsulated VEGF activities …”

Section: Combined Therapeutic Effects Of Plga and Loaded Drug On Wounmentioning

confidence: 95%

PLGA based drug delivery systems: Promising carriers for wound healing activity

Chereddy

Vandermeulen

Préat

2016

Wound Repair Regeneration

Self Cite

170

View full text Add to dashboard Cite

Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Current treatment options are limited and require repeated administrations which led to the development of new therapeutics to satisfy the unmet clinical needs. Many potent wound healing agents were discovered but most of them are fragile and/or sensitive to in vivo conditions. Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer approved by food and drug administration and European medicines agency as an excipient for parenteral administrations. It is a well-established drug delivery system in various medical applications. The aim of the current review is to elaborate the applications of PLGA based drug delivery systems carrying different wound healing agents and also present PLGA itself as a wound healing promoter. PLGA carriers encapsulating drugs such as antibiotics, anti-inflammatory drugs, proteins/peptides, and nucleic acids targeting various phases/signaling cycles of wound healing, are discussed with examples. The combined therapeutic effects of PLGA and a loaded drug on wound healing are also mentioned.

show abstract

Section: Combined Therapeutic Effects Of Plga and Loaded Drug On Wounmentioning

confidence: 95%

PLGA based drug delivery systems: Promising carriers for wound healing activity

Chereddy

Vandermeulen

Préat

2016

Wound Repair Regeneration

Self Cite

170

View full text Add to dashboard Cite

show abstract

“…[111] Chereddy et al encapsulated the vascular endothelial growth factor (VEGF), and the studies performed by the authors revealed that VEGF-loaded PLGA nanoparticles enhanced the migration and proliferation www.advancedsciencenews.com www.advhealthmat.de of keratinocytes, while upregulating the expression of VEGFR2 at the mRNA level. [112] Xiong et al also showed a successful action of VEGF-loaded PLGA nanoparticles in the promotion of blood vessels and smooth muscle fibers regeneration, in the bladder of a swine model, and that the nanoparticles were able to release VEGF for at least 3 months. [113] Despite all the advantages concerning PLGA-based DDSs, there are still some issues to be overcome when nanoparticles are administered, especially into bloodstream.…”

Section: Poly(lactic-co-glycolic) Acid Nanoparticlesmentioning

confidence: 98%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

214

133

View full text Add to dashboard Cite

Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

show abstract

“…Wound dressings can be medicated to deliver therapeutic substances, such as growth factors, drugs and stem cells [30]. PLGA-based scaffolds can be used as drug delivery systems for bFGF [33], VEGF [10,30], rhEGF [34], insulin [11], platelet-rich plasma [35] and adipose stem cells [36]. NT is beneficial for diabetic wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Wound dressings using nanotechnology have been developed as tissue-engineered scaffolds for skin [9]. They can be combined with drugs to enhance their effects, such as the combination of polylactide-polyglycolide (PLGA) and vascular endothelial growth factor (VEGF) [10], insulin-loaded poly-PLGA composite microspheres [11] and collagen/cellulose nanocrystal (CNC)/basic fibroblast growth factor (bFGF)-biodegradable gelatin microspheres scaffolds [12]. However, DFUs are still difficult to treat, require long hospital stays and expensive treatments and can involve major complications.…”

Section: Introductionmentioning

confidence: 99%

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Zheng

Liu

Huang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Diabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds. This study aims to explore the therapeutic efficacy and possible mechanisms of NT-loaded PLGA/CNC nanofiber membranes in full-thickness skin wounds in spontaneously diabetic mice. The results showed that NT could be sustained released from NT-loaded PLGA/CNC composite nanofiber membranes for 2 weeks. NT-loaded PLGA/CNC composite nanofiber membranes induced more rapid healing than other control groups. After NT exposure, the histological scores of the epidermal and dermal regeneration and the ratios of the fibrotic area to the whole area were increased. NT-loaded PLGA/CNC composite nanofiber membranes also decreased the expressions of the inflammatory cytokines IL-1β and IL-6. These results suggest that NT-loaded PLGA/CNC composite nanofiber membranes for sustained delivery of NT should effectively promote tissue regeneration for the treatment of DFUs.

show abstract

Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds

Cited by 119 publications

References 33 publications

PLGA based drug delivery systems: Promising carriers for wound healing activity

PLGA based drug delivery systems: Promising carriers for wound healing activity

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Contact Info

Product

Resources

About