Combined exercise and calorie restriction therapies restore contractile and mitochondrial functions in skeletal muscle of obese–insulin resistant rats

Pattanakuhar, Sintip; Sutham, Wissuta; Sripetchwandee, Jirapas; Minta, Wanitchaya; Mantor, Duangkamol; Palee, Siripong; Pratchayasakul, Wasana; Chattipakorn, Nipon

doi:10.1016/j.nut.2018.11.031

Cited by 19 publications

(9 citation statements)

References 47 publications

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“…Our study also found that HIIT could significantly reduce the expression of the DRP1 gene in the livers of T2DM mice. Previous studies have found that exercise can reduce DRP1 protein phosphorylation in the skeletal muscle of obese rats [ 58 ]. The above results show that exercise can restore the dynamic balance of mitochondria by increasing mitochondrial fusion and decreasing fission in T2DM mice.…”

Section: Discussionmentioning

confidence: 99%

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

Wang

Guo

et al. 2022

Metabolites

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High-intensity interval training (HIIT), a new type of exercise, can effectively prevent the progression of metabolic diseases. The aim of this study was to investigate the effects of HIIT on liver inflammation and metabolic disorders in type 2 diabetes mellitus (T2DM) mice induced by a high-fat diet (HFD) combined with streptozotocin (STZ) and to explore the possible mechanisms of macrophage polarization and mitochondrial dynamics. Our results showed that HIIT can increase fatty acid oxidation-related gene (PPARα, CPT1α, and ACOX1) mRNA levels and decrease adipogenesis-related gene (PPARγ) mRNA levels to improve liver metabolism in T2DM mice. The improvement of lipid metabolism disorder may occur through increasing liver mitochondrial biosynthesis-related genes (PGC-1α and TFAM) and restoring mitochondrial dynamics-related gene (MFN2 and DRP1) mRNA levels. HIIT can also reduce the mRNA levels of liver inflammatory factors (TNF-α, IL-6, and MCP-1) in T2DM mice. The reduction in liver inflammation may occur through reducing the expression of total macrophage marker (F4/80) and M1 macrophage marker (CD86) mRNA and protein and increasing the expression of M2 macrophage marker (CD163, CD206, and Arg1) mRNA and protein in the liver. HIIT can also increase the expression of insulin signaling pathway (IRS1, PI3K, and AKT) mRNA and protein in the liver of T2DM mice, which may be related to the improvements in liver inflammation and lipid metabolism. In conclusion, these results suggested that 8 weeks of HIIT can improve inflammation and lipid metabolism disorders in the liver of type 2 diabetes mellitus mice, macrophage M1/M2 polarization, and mitochondrial dynamics may be involved in this process.

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Section: Discussionmentioning

confidence: 99%

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

Wang

Guo

et al. 2022

Metabolites

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“…That study suggests that CR promotes mitochondrial adaptation in the skeletal muscle, since it attenuates the effect of resistance training upon muscle hypertrophy. Finally, another study demonstrated that both CR and exercise training in obese rats was able to alleviate reduced mitochondrial fusion stimulated by HFD, since they induced MFN2 expression and reduced the phosphorylation of DPR1 protein at Ser 616 ( 115 ). In this case, the CR diet appears to act synergistically with exercise against the HFD-induced mitochondrial fusion.…”

Section: Dietsmentioning

confidence: 99%

The impact of diet upon mitochondrial physiology (Review)

et al. 2022

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Mitochondria are considered the 'powerhouses' of cells, generating the essential energy in the form of adenosine triphosphate that they need for their energy demands. Nevertheless, their function is easily adaptable as regards the energy demands and the availability of chemical substrates. This allows cells to buffer sudden changes and reassure cellular metabolism, growth or survival. currently, humans have different dietary habits, which provide several stimuli to the cell. According to the energy substrate availability due to the diet quality and diet temporality, mitochondrial physiology is greatly affected. The present review article aimed to collect all the available information that has been published to date concerning the impact of five different popular diets (high-fat diet, ketogenic diet, fasting, caloric restriction diet and the Mediterranean diet) on specific mitochondrial physiological aspects, such as function, biogenesis, mitophagy and mitochondrial fission/fusion. Contents 1. Mitochondrial physiology 2. diets 3. clinical impact 4. conclusions

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“…Given the potentially important role of mitochondria in COVID-19 pathogenesis, optimizing mitochondrial health can be an effective strategy in prevention and treatment. Mitochondrial health can be improved by exercise, calorie restriction, and attaining an optimal BMI (Hoeks and Schrauwen, 2012;Pattanakuhar et al, 2019). A range of mitochondrial supplements are also available to boost mitochondrial function (Table 1).…”

Section: Covid-19 Treatment and Prevention: Mitochondrial Perspectivementioning

confidence: 99%

COVID-19: A Mitochondrial Perspective

Prasun

2021

DNA and Cell Biology

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Coronavirus disease 2019 is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.

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Combined exercise and calorie restriction therapies restore contractile and mitochondrial functions in skeletal muscle of obese–insulin resistant rats

Cited by 19 publications

References 47 publications

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

The impact of diet upon mitochondrial physiology (Review)

COVID-19: A Mitochondrial Perspective

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