2021
DOI: 10.1016/j.obmed.2021.100336
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Combined ginger and garlic extract improves serum lipid profile, oxidative stress markers and reduced IL-6 in diet induced obese rats

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Cited by 15 publications
(9 citation statements)
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“…In line with this result, ginger extract at 50 mg/kg remarkably attenuated the serum levels of TNF- α , IL-6, and IL-17 in the ginger group than in the type 2 collagen and Freund's adjuvant-induced arthritis group [ 48 ]. Also, Adegbola et al demonstrated that the ginger extract at a dose of 500 mg/kg alone or in combination with Allium sativum 1000 mg/kg significantly declines the inflammation following the high-fat diet-induced obesity in rats by decreasing the IL-6 and TNF- α levels and lipid profile [ 49 ]. Another study showed that oral administration of Zingiber officinalis extract at doses of 100 and 1000 mg/kg strongly diminishes LPS-Induced Inflammation by downregulating the release of proinflammatory cytokines such as IFN- γ and IL-6 [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…In line with this result, ginger extract at 50 mg/kg remarkably attenuated the serum levels of TNF- α , IL-6, and IL-17 in the ginger group than in the type 2 collagen and Freund's adjuvant-induced arthritis group [ 48 ]. Also, Adegbola et al demonstrated that the ginger extract at a dose of 500 mg/kg alone or in combination with Allium sativum 1000 mg/kg significantly declines the inflammation following the high-fat diet-induced obesity in rats by decreasing the IL-6 and TNF- α levels and lipid profile [ 49 ]. Another study showed that oral administration of Zingiber officinalis extract at doses of 100 and 1000 mg/kg strongly diminishes LPS-Induced Inflammation by downregulating the release of proinflammatory cytokines such as IFN- γ and IL-6 [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…These results were also consistent with other studies that revealed the effect of HFD rat and obese diabetic patients on TNF-α and IL-6. 24,25 Cholesterol and saturated fatty acids (SFAs) are examples of WD ingredients that relate to the inflammatory response in the immune system. 26 Insulin resistance in the WD model may cause hypertriglyceridemia and hypercholesterolemia, which induce lipotoxicity and hepatic steatosis.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, spice extract and its active components are very favorable for improving diabetic vascular complications. [18] Diabetes will cause central nervous lesions in the late stages of the disease, resulting in cognitive dysfunction and the development of some neurodegenerative diseases. Neurotoxicity can result from abnormal -amyloid protein expression, leading to severe neurodegenerative diseases such as Alzheimer's disease.…”
Section: Spices Extract and Its Active Components Improve Diabetic Co...mentioning
confidence: 99%