Combined Hepatocellular Carcinoma and Cholangiocarcinoma With High F-18 Fluorodeoxyglucose Positron Emission Tomographic Uptake

Shiomi, Susumu; Sasaki, Nobumitsu; Kawashima, Daichi; Jomura, Hisato; Fukuda, Takashi; Kuroki, Tetsuo; Koyama, Kouichi; Kawabe, Joji; Ochi, Hironobu

doi:10.1097/00003072-199905000-00024

Cited by 12 publications

(3 citation statements)

References 2 publications

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“…The liver, and also muscle, intestine and kidneys, are known to have increased activity of glucose‐6‐phosphatase (22,23). This may result in increased accumulations of FDG in HCC compared to normal liver tissue, as confirmed by others (2,24–37) PET using 18 FDG is the most sensitive technique for imaging and quantification of glucose metabolism. Established and reimbursed oncological applications for FDG‐PET are well known (38).…”

Section: Discussionmentioning

confidence: 53%

Fluorine‐18 FDG imaging in hepatocellular carcinoma using positron coincidence detection and single photon emission computed tomography

Verhoef¹,

Valkema

Man

et al. 2002

Liver

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Section: Discussionmentioning

confidence: 53%

Fluorine‐18 FDG imaging in hepatocellular carcinoma using positron coincidence detection and single photon emission computed tomography

Verhoef¹,

Valkema

Man

et al. 2002

Liver

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“…We reported high FDG‐PET accumulation in combined HCC and CCC, and FDG‐PET is also considered useful for the diagnosis of the disease 34 . Furthermore, it has been reported that FDG‐PET was useful for the diagnosis of leiomyosarcoma of the liver 35 and hepatic epithelioid hemangioendothelioma 36 …”

Section: Fdg‐pet For Other Intrahepatic Tumorous Lesionsmentioning

confidence: 80%

Clinical applications of positron emission tomography in hepatic tumors

Shiomi

Kawabe

2011

Hepatology Research

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Fluorodeoxyglucose (FDG), which allows the evaluation of glucose metabolism, is widely used for tumor diagnosis using positron emission tomography (PET). FDG-PET, which is used for the diagnosis of intrahepatic tumor lesions, shows high FDG accumulation in cholangiocellular carcinoma (CCC) and metastatic liver cancer. FDG-PET shows high FDG accumulation in moderately or poorly differentiated hepatocellular carcinoma (HCC) and is useful for the diagnosis of extrahepatic HCC metastases and recurrences. However, because the imaging method frequently shows low FDG accumulation in well-differentiated HCC, it is not very useful for that diagnosis. For the diagnosis of well-differentiated HCC, F-18 fluorocholine for evaluation of phospholipid metabolism and C-11 acetate for evaluation of free fatty acid metabolism are useful in the diagnosis of that HCC. It is expected that the combination of these PET agents will enhance the diagnostic performance of FDG-PET for HCC in the future. The problem of a lack of anatomical information is being resolved with the development of the use of PET in combination with computed tomography or magnetic resonance imaging. For the problem of low resolution, PET devices using semiconductors have been developed.

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“…For example, a tumor demonstrating enhancement pattern suggestive of HCC with additional imaging findings characteristic of ICC such as biliary obstruction out of proportion to tumor size [11]. Another imaging characteristic that has been described is that these tumors tend to be intensely FDG avid on PET imaging [13]. On ultrasound imaging these tumors have variable echogenicity and therefore may not be useful in suggesting the diagnosis of cHCC-CC [4,11].…”

Section: Combined Hepatocellular Carcinoma and Cholangiocarcinomamentioning

confidence: 99%