Combined hepatoid and serous carcinoma of the uterine corpus: an undescribed phenomenon

Moritani, Suzuko; Ichihara, Shu

doi:10.1111/his.12614

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…All reported cases of EHC have been associated with other types of carcinomas or appeared as a carcinoma component of a carcinosarcoma. In most cases, the associated carcinoma was endometrioid and only 1 case was associated with serous carcinoma 2. This case and the present case indicated that not only endometrioid carcinoma, but also serous carcinoma can transform to a hepatoid carcinoma.…”

Section: Discussionsupporting

confidence: 61%

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High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component

Nishida

Toji

Taniguchi

et al. 2022

International Journal of Gynecological Pathology

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Endometrial carcinoma with hepatoid differentiation is rare and <20 reported cases have been reported as endometrial hepatoid carcinoma (EHC). We present a case of EHC associated with serous carcinoma in a 76-yr-old Japanese woman. The hepatoid component showed trabecular, pseudoglandular, and diffuse proliferation of hepatoid cells. The hepatoid cells were positive for α-fetoprotein, Hep-Per-1, glypican 3, and HNF-1β, weakly and focally positive for SALL4, and negative for PAX8. Both of the serous and hepatoid components showed overexpression of p53. The serum α-fetoprotein on postoperative day 5 was 3691 ng/mL. The postoperative course has remained uneventful for 4 yr. These findings suggested that EHC developed from serous carcinoma by acquiring hepatocytic features and losing Müllerian features. Both serous and hepatoid components showed p53 overexpression, suggesting they share a TP53 mutation as a common primary driver.

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Section: Discussionsupporting

confidence: 61%

“…The overexpression of p53 in EHC was studied in only 3 cases, including the present case. Two cases had a serous carcinoma component and 1 case had an endometrioid carcinoma component (2,3). The present case and 1 case of endometrioid carcinoma exhibited p53 overexpression in both hepatoid and nonhepatoid components (3).…”

Section: Pathologic Findingsmentioning

confidence: 53%

High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component

Nishida

Toji

Taniguchi

et al. 2022

International Journal of Gynecological Pathology

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“…Hepatoid adenocarcinoma (HAC) is a rare and typically aggressive extrahepatic tumor which resembles hepatocellular carcinoma (HCC) and is most commonly reported in abdominal-pelvic organs and the lungs. 1 , 2 , 3 , 4 , 5 , 6 , 7 It has also been recently reported in the anterior skull base. 8 To our knowledge, this is the first case of primary HAC of the orbit, although it must be acknowledged that the tumor may have originated in the frontal sinus or frontal bone.…”

Section: Discussionmentioning

confidence: 76%

“…This and previous reports indicate HAC to be an aggressive tumor with poor prognosis. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 Treatment is not well defined but previous strategies have included surgical excision or de-bulking, chemotherapy, and radiation. 2 , 3 , 4 , 5 , 6 , 7 , 8 Unfortunately, our patient's tumor was highly aggressive and continued to rapidly progress despite surgical de-bulking and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…HAC is most commonly reported in the stomach, and has been identified in multiple abdominal-pelvic organs, the lungs, and other sites. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 Typically, patients with HAC present with elevated serum alpha-fetoprotein (AFP), and with tumor immunohistochemistry positivity for AFP, however both of these features are variable in reports. 1 Although HAC of the skull base has recently been reported, to our knowledge, it has not yet been reported as a primary tumor of the orbit.…”

Section: Introductionmentioning

confidence: 99%

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Primary hepatoid adenocarcinoma of the orbit

Alsberge

Grumbine

Bloomer

et al. 2017

American Journal of Ophthalmology Case Reports

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PurposeTo report a case of primary hepatoid adenocarcinoma of the orbit.ObservationsAn adult patient was referred for evaluation of an orbital mass. Histopathology of the orbital biopsy indicated a carcinoma with hepatoid features. Laboratory studies revealed normal liver function tests, elevated serum alpha-fetoprotein, and whole-body positron emission tomography/computed tomography scan showed no evidence of liver involvement or an alternative primary origin.Conclusions and importanceTo the authors' knowledge, this is the first reported case of primary hepatoid adenocarcinoma of the orbit.

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α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 Abnormalities, and Poor Prognosis: Five Cases and Literature Review

et al. 2021

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The clinicopathological, immunohistochemical, and molecular characteristics of α-fetoprotein (AFP)-producing endometrial carcinoma (AFP+ EC) are poorly understood. From 284 cases of endometrial carcinoma in our pathology archive, we identified five cases (1.8%) of AFP+ EC with fetal gut–like (4/5) and/or hepatoid (2/5) morphology. All cases exhibited lymphovascular infiltration. In addition, 24 cases of endometrial carcinoma with elevated serum AFP levels were retrieved from the literature. The patient age ranged from 44 to 86 years (median: 63). Of 26 cases whose FIGO (International Federation of Gynecology and Obstetrics) stage and follow-up information was available (mean follow-up 24 months), 15 were stage I or II and 11 were stage III or IV. Even in stage I or II disease, death or relapse occurred in more than half of the patients (8/15). Detailed analysis of our five cases revealed that, on immunohistochemistry, AFP+ EC was positive for SALL4 (4/5), AFP (3/5), and HNF1β (4/5) in >50% of neoplastic cells and negative for estrogen and progesterone receptors (5/5), PAX8 (4/5), and napsin A (5/5). Four cases exhibited aberrant p53 immunohistochemistry and were confirmed to harbor TP53 mutations by direct sequencing. No mutation was found in POLE, CTNNB1, or KRAS. In conclusion, AFP+ EC merits recognition as a distinct subtype of endometrial carcinoma, which occurs in 1.8% of endometrial carcinoma cases, are associated with TP53 abnormalities, exhibit lymphovascular infiltration, and can show distant metastasis even when treated in early stage.

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Combined hepatoid and serous carcinoma of the uterine corpus: an undescribed phenomenon

Cited by 3 publications

References 20 publications

High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component

High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component

Primary hepatoid adenocarcinoma of the orbit

α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 Abnormalities, and Poor Prognosis: Five Cases and Literature Review

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