Combined laser and ozone therapy for onychomycosis in an in vitro and ex vivo model

Fernández, Javier; Fernández, Iván del Valle; Villar, Claudio J.; Lombó, Felipe

doi:10.1371/journal.pone.0253979

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…In Group 1, there was an overall infection measurement decrease of 4.578, which correspond with literature [28,38]. Group 2 showed an overall infection measurement decrease of 7.2270, which was statistically significant (p ≤ 0.01 (**)) and may be due to the higher SCIO at Week 1.…”

Section: Scio Decreasesupporting

confidence: 80%

The Efficacy of Phototherapy for the Treatment of Onychomycosis: An Observational Study

Dembskey

Abrahamse

2021

Photonics

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(1) Background: Onychomycosis accounts for 50% of nail pathologies and is a therapeutic challenge due to an increase in resistance to antifungal agents. This study aimed to explore the effectiveness of 1064 nm diode laser irradiation for the treatment of Onychomycosis and establish a new set of laser parameters for effective and safe treatment; (2) Methods: An exploratory, single-blinded study was conducted on forty-five patients with toenail Onychomycosis. Digital images and nail clippings were taken for Periodic Acid-Schiff (PAS) staining and fungal microscopy and culture (MC&S). Group 1 received 5% topical Amorolfine lacquer to apply to affected nails. Group 2 received 1064 nm diode laser treatment at 10 mW/s, hallux 790 J/cm2 and lesser digits 390 J/cm2 (standard treatment). Group 3 received 1064 nm diode laser treatment at 10 mW/s, hallux 1 100 J/cm2 and lesser digits 500 J/cm2 (new treatment parameters). After laser treatment, nail temperatures were taken with a surface thermometer; (3) Results: PAS staining was more sensitive in identifying Onychomycosis (91.1%), compared to Fungal Microscopy (44.4%). Comparing treatment requirements over a period of 24 weeks, there was a statistical significance, p ≤ 0.01 (**), for standard laser treatment and, p ≤ 0.001 (***), for new laser parameter treatment, indicating treatment needed over time decreased. No adverse effects were noted with new laser therapy. An 86.7% visual improvement was noted in Group 3 after 24 weeks; (4) Conclusions: Phototherapy, or photo thermolysis, was the best treatment option for Onychomycosis. A new protocol for the standardization of laser irradiation with the possible inclusion into the Scoring Clinical Index for Onychomycosis treatment plan, was proposed.

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Section: Scio Decreasesupporting

confidence: 80%

The Efficacy of Phototherapy for the Treatment of Onychomycosis: An Observational Study

Dembskey

Abrahamse

2021

Photonics

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“…Laser therapy and photodynamic therapy (PDT) are those medical treatments that use light to treat various medical conditions, including cancer, skin disorders, and eye problems. Both therapies harness the power of light for therapeutic purposes, but they differ in their mechanisms and applications 48 . These therapies aim to immediately attack the fungal infection by penetrating the tough nail plate.…”

Section: Combination Therapies For Enhanced Efficacymentioning

confidence: 99%

Untitled

2024

IJPSR

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The most prevalent condition affecting the nails is onychomycosis. It is a typical nail fungal infection that causes millions of individuals globally. Yeasts, non-dermatophyte moulds, and dermatophytes can all be the cause. It's not only results in physical discomfort but also has a major negative effect on the affected person's quality of life. This infection affects the nails of the toes and fingers, causing discoloration, thickness, and brittleness of the nails. While the condition is not life threating, but it can be uncomfortable and unsightly, leading many patients to seek treatment. Previously these treatments ranged from oral medication to topical ointments and laser therapy, each with its benefits and drawbacks Fortunately, recent improvements in onychomycosis diagnosis and treatment have provided new hope for patients. It will deal with the recent treatment available and the novel treatment which can be developed. In this comprehensive review, we will explore the latest research and developments in the field, discussing novel treatment modalities, diagnostic techniques, and safety considerations. Additionally, new techniques include photodynamic treatment and laser therapy are discussed, emphasizing their potential in overcoming the limitations of traditional treatments. Furthermore, we examine the importance of early diagnosis and patient education in improving treatment outcomes. INTRODUCTION:Nail fungus, or onychomycosis, is characterised by thickness, discoloration, and detachment of the nail from the nail bed. Dermatophytes, like Trichophyton rubrum and mentagrophytes, are the main culprits; they cause about 90% of nail infections in toenails and 75% of nail infections in fingers. Onychomycosis can also be caused by other organisms, such as yeasts and non-dermatophyte Moulds 1-5 .

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“…Ozonated hydrotherapy involves physically dissolving ozone in water (rather than chemically). Ozonated hydrotherapy can aid in treating dermatological diseases, such as infectious skin diseases, 25 , 26 atopic dermatitis, 11 psoriasis, 9 pemphigus, 12 and diabetic foot. 15 In addition, ozone water can be used to clean burns and scald wounds, accelerate wound healing, 14 and promote skin repair after laser cosmetology.…”

Section: The Application Of Ozone In Dermatologymentioning

confidence: 99%

Ozone therapy for skin diseases: Cellular and molecular mechanisms

Liu

Zeng

Gao

et al. 2022

International Wound Journal

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Ozone is a highly reactive oxidant molecule consisting of triatomic oxygen atoms. Ozone therapy can be achieved using ozonated hydrotherapy, ozonated oil, ozone autohemotherapy, and other innovative dosage forms of ozone products. Ozone is frequently used as a complementary therapy for various cutaneous diseases, including infectious skin diseases, wound healing, eczema, dermatitis, psoriasis, axillary osmidrosis, diabetic foot, and pressure ulcers. In addition, several studies have reported the superior potential of ozone therapy for improving skin and gut microbiomes, as well as antitumour and antiaging treatment. Ozone therapy is an emerging treatment strategy that acts via complex mechanisms, including antioxidant effects, immunomodulatory capacity, and modulation of local microcirculation. Studies assessing the mechanism of ozone have gradually expanded in recent years. This review article aims to summarise and explore the possible molecular biological mechanisms of ozone in cutaneous diseases and provide compelling theoretical evidence for the application of ozone in cutaneous diseases.

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Combined laser and ozone therapy for onychomycosis in an in vitro and ex vivo model

Cited by 7 publications

References 41 publications

The Efficacy of Phototherapy for the Treatment of Onychomycosis: An Observational Study

The Efficacy of Phototherapy for the Treatment of Onychomycosis: An Observational Study

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Ozone therapy for skin diseases: Cellular and molecular mechanisms

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