Postoperative survival and cardiac function were studied in 45 patients who underwent combined mitral and aortic valve replacement by Bjork-Shiley prostheses between 1971 and 1977. The average follow-up was three years. Pre-operative left ventricular ejection fraction ranged from 28 to 78% (mean 57%). The hospital mortality rate for the entire series was 18%, the five year survival rate 58%. Hospital mortality decreased from 22% in 1971/72 to 8% in 1976/77. Sixteen patients were restudied 12 to 60 months after operation. In these patients functional class improved significantly, pulmonary arteriolar resistance decreased (255 to 122 dynes s cm" 5 , P < 0-05), left ventricular enddiastolic volume (159 to 103 ml/m*, P < 0-01), muscle mass (198 to 134ml/m 2 , P < &05) and ejection fraction improved (50 to 61%, P < 0-05). Postoperatively, mean pulmonary artery pressure increased with exercise (23 to 41 mm Hg, P < 0-001), and pulmonary artery pressure during exercise was linearly related to pulmonary arteriolar resistance at rest (r=0~72, P < &05). Patients with successful repair of mitral and aortic valve without a paravalvular leak achieved normal pulmonary arteriolar resistance, left ventricular end-diastolic volume, muscle mass and ejection fraction, but cardiac index remained slightly reduced as compared to a control group (2'8 v. 3 3 l/min m 2 , P < 0-05). This study shows (I) early and late mortality rates remained high after double valve replacement by Bjork-Shiley prostheses, but hospital mortality decreased in the time period analysed, and (2) late survivors revealed normalization of left ventricular dilation, hypertrophy and ejection fraction when the prosthesis functioned well. Operative management of combined mitral and function before and following double valve replaceaortic valve disease by use of various types of ment. Thus, it is unknown which adaptive changes prostheses has been shown to improve clinical of the left ventricle occur after unloading by double symptomst 1 " 8 ], but the hemodynamic response of valve replacement. This study compares prethe left ventricle to operation has been rarely operative and postoperative angiographic findings studied. Mason et a/.l'l reported data of patients to answer the question whether left ventricular who showed an abnormal function of the left dilatation and dysfunction recover after double ventricle during exercise after operation. Nitter-valve replacement. Hauge et a/.['°l studied patients after double valve replacement by Lillehei-Kaster prosthesis and found normalization of cardiac output and pul-Methods monary arteriolar resistance. However, none of the previous studies reported data regarding left ven-PATIENTS tricular dilatation, hypertrophy and contractile We studied 45 patients who underwent combined mitral and aortic valve replacement between May