Combined Modality Treatment for Patients With Inoperable Colorecral Liver Metastases

Abstract

The purpose of the study was to improve treatment outcomes for patients with inoperable colorectal liver metastases using the combination of chemoembilization of the hepatic artery and radiofrequency ablation.Material and methods. Treatment outcomes of 60 patients with methachronic unresectable liver metastases from colorectal cancer were analyzed. Eligibility criteria were as follows: absence of extrahepatic metastases, size of metastases from 3 to 5 cm, and inability to perform resection. All patients were divided into two groups. Group I included 30 patients who received combination of regional chemotherapy and radiofrequency ablation. Group II (the control group) consisted of 30 patients who received radiofrequency ablation only.Results. Post-embolization and post-ablation syndromes were observed in both groups of patients. Rightsided hydrothorax (Clavien-Dindo grade II) was found in 4 out of 60 patients (2 patients in Group I and 2 patients in Group II). One-, two- and three-year disease-free survival rates in Group I patients were 96.6 %, 76.6 % and 53.3 %, respectively. The corresponding rates in the control group patients were 90.0 %, 53.6 % and 30.0 %, respectively (p=0.049). The overall one-, two-and three-year survival rates in Group I patients were 100 %, 90 % and 63.3 %, respectively. The corresponding rates in the control group patients were 100 %, 70 % and 50.0 %, respectively (p=0.202).Conclusion. The combination of regional chemotherapy and radiofrequency ablation led to the improvement in overall and disease-free survival rates.

Magnetic Nanomaterials for Arterial Embolization and Hyperthermia of Parenchymal Organs Tumors: A Review

“…Hyperthermia in combination with RT and ChT is widely used in Europe, the United States, Japan, China, Russia, and other countries for the treatment of different tumor types and sites: mammary gland, prostate gland, lung, liver, intestinal tract, bonny tissue, glioblastoma, etc. [9][10][11][12][13][14][15][16][17][18][19][20][21]. Preclinical in vitro and in vivo studies have shown two aspects of cancer inhibition by combining HT with RT and ChT: the death of individual cells from hyperthermia and enhancing the effects of RT and ChT [15].…”

“…The additional benefit of HT in combination with RT and ChT has been shown in a number of randomized clinical trials. Thus, for example, the overall response rate increased from 38% to 60% for patients with breast cancer who received HT + RT, while the treatment of cervical cancer at stage IIB-III-IVA with a combination of RT, ChT, and HT showed improved complete response rates and significantly increased overall survival [16,17]. Combining these methods has also proven to be effective in the preoperative treatment of stage III lung cancer [19].…”

Investigation Kras Mutation in Circulation Tumor Dna in Different Stages of Colorectal Cancer

“…мутация в этом гене возникает на ранних этапах канцерогенеза [5], участвует в активации раковых стволовых клеток [12] и связана с более быстрым и агрессивным метастазированием [13]. Кроме того, её наличие указывает на невозможность применения таргетных анти-EGFR препаратов [11], используемых при лечении метастатического колоректального рака, который выявляют у каждого третьего пациента на момент постановки диагноза [16]. *-8 издание классификации TNM злокачественных новообразований [7] Определение мутационного статуса опухоли образцы нефиксированной опухолевой ткани были взяты под контролем врача-патоморфолога в короткое время после резекции кишки (не более 30 мин).…”