Combined Neutrophil and Erythrocyte Agglutination in a 7-year-old Boy

Yenson, Paul R.; Fleming, Adam; Kaikov, Yigal; Wadsworth, Louis D.

doi:10.1097/mph.0b013e3181461662

Cited by 5 publications

(4 citation statements)

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“…Aggregation of lymphocytes (Lymphoagglutination) is an extremely rare, EDTA-dependent phenomenon and is far less frequent than Neutrophils agglutination [4,5]. Sometime, leucoagglutination is accompanied with platelet aggregation [6] or erythrocyte aggregation [7]. The phenomenon described here is distinct from artificial leucocyte aggregation (artifact) at the edge of a blood smear sometimes observed during blood smear preparation.…”

Section: Discussionmentioning

confidence: 72%

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Cold-Induced Pseudoneutropenia in Human Immunodeficiency Virus Infection: First Case Report and Review of Related Articles

Goyal

Agrawal

Kailash³

et al. 2013

Indian J Hematol Blood Transfus

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Cold agglutination of erythrocyte or platelet aggregation in vitro due to cold agglutination are well recognized and extensively studied. Aggregation of leucocyte is a rare hematological phenomenon resulting in a spurious low leucocyte count performed using automated hematology analyzers. Aggregation of leucocyte may relate to malignancy, lymphoproliferative disorders, infection, liver diseases, or autoimmune disorders. It is believed that the mechanism of leucocyte aggregation is mainly related to the use of ethylene diamine tetraacetic acid (EDTA) anticoagulant or is temperature-mediated. Leucoagglutination is associated with either a spurious leucopenia or an underestimation of leucocytosis. This can adversely affect management decisions in terms of unnecessary management of leucopenia or ignoring a leucocytosis that may be indicator of an underlying serious disease. To our knowledge, we report here for the first time the occurrence of pseudoneutropenia due to temperature-mediated, EDTAindependent neutrophil agglutination in adult with human immunodeficiency virus infection.

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Section: Discussionmentioning

confidence: 72%

“…Colon cancer [8], liver cell carcinoma [9] etc. ), infection or inflammation (chest infection or pneumonia [3,7,[10][11][12], gastroenteritis, mycoplasma, EV virus, Herpes simplex [3,7], etc. ), hepatic disorders, shock, or autoimmune disease [6].…”

Section: Discussionmentioning

confidence: 99%

Cold-Induced Pseudoneutropenia in Human Immunodeficiency Virus Infection: First Case Report and Review of Related Articles

Goyal

Agrawal

Kailash³

et al. 2013

Indian J Hematol Blood Transfus

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“…Similarly, some case studies reported patients coinfected with MP and EBV suffered more severe symptoms. [ 17 , 18 ] For example, Li et al presented a case of EBV and MP coinfection complicated with splenic infarction. [ 17 ] Combined leukocyte and erythrocyte agglutination was described in a 7-year-old patient with MP and EBV coinfection by Yenson et al [ 18 ] These together indicated that to some extent MPP children with EBV coinfection had a more severe illness.…”

Section: Discussionmentioning

confidence: 99%

Impact of Epstein-Barr virus coinfection in Mycoplasma pneumoniae pneumonia

Liu

et al. 2020

Medicine

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Mycoplasma pneumoniae (MP) is one of the most common pathogens of respiratory infection in children, while Epstein-Barr virus (EBV) infection is usually subclinical in immunocompetent children. Although single MP infection is common enough, MP and EBV coinfection have received little attention. Especially, the pathogenic role of EBV in lung when coinfection with MP, has not been clarified. The purpose of this study was to investigate the impact of EBV on MP pneumonia (MPP) in hospitalized children. We retrospectively reviewed the clinical data of MPP children who underwent screening for EBV by polymerase chain reaction in bronchoalveolar lavage fluid during hospitalization in 2014. Of total 147 patients, 68 patients were in the MP group and 79 were in the MP/EBV coinfection group. We found longer fever duration and higher CRP, IgA, IgG, interleukin-2 (IL-2), percentage of peripheral neutrophils levels, higher incidence of pulmonary consolidation and percentage of refractory MPP in coinfection group, when compared to those in MP group. In ROC curve analysis, IL-2 was useful for differentiating patients with coinfection from those with MP infection. Logistic regression analysis showed that the IL-2 ≥ 3.35 pg/ml (OR = 3.677) was a significant predictor regarding to MP/EBV coinfection. In conclusion, coinfection of EBV and MP poses a higher risk for prolonged symptoms. IL-2 could be used as a good predictor of coinfection.

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“…The aggregation of leukocytes may also be temperature-dependent 1 and sometimes is accompanied with red cell autoagglutination. 6 At times, leukoagglutination can be time-dependent when immediate processing abolishes the agglutination. In some patients,…”

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confidence: 99%