2022
DOI: 10.1101/2022.01.17.476660
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Combined patterns of activity of major neuronal classes underpin a global change in brain state during spontaneous and forced walk inDrosophila

Abstract: Movement and behavioral state influence perception, and a stimulus can elicit opposite behavioral actions depending on whether the animal is moving toward or away from it. Here, we use fast wholebrain lightfield imaging in adult Drosophila melanogaster to analyze the relationship between movement and neuronal activity. Using pan-neuronal calcium imaging, we observe brainwide neuronal activity that tightly correlated with spontaneous bouts of movement. Imaging of specific sets of neurons across the brain reveal… Show more

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Cited by 13 publications
(8 citation statements)
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“…The population of 4Ns also included descending neurons, neurons that project to the ventral nerve cord and regulate body movements such as locomotion. Three of these descending neurons (types oviDNa and oviDNb) drive egg-laying behavior (Wang et al, 2020), while a fourth, DNp32, is activated during walking (Aimon et al, 2022). Given that mlSEZt activation elicits turning (Figure 8F), we searched for downstream connections to DNa02, a descending neuron that controls turning (Rayshubskiy et al, 2020).…”
Section: Resultsmentioning
confidence: 99%
“…The population of 4Ns also included descending neurons, neurons that project to the ventral nerve cord and regulate body movements such as locomotion. Three of these descending neurons (types oviDNa and oviDNb) drive egg-laying behavior (Wang et al, 2020), while a fourth, DNp32, is activated during walking (Aimon et al, 2022). Given that mlSEZt activation elicits turning (Figure 8F), we searched for downstream connections to DNa02, a descending neuron that controls turning (Rayshubskiy et al, 2020).…”
Section: Resultsmentioning
confidence: 99%
“…For instance, recent evidence suggests that changes in hormone levels trigger circuit maturation in Drosophila flies during the first week of life (Leinwand & Scott, 2021). We used whole brain lightfield imaging to record the activity of all neurons in the brain in living female flies ( nsyb-Gal4;UAS-CaMP ) (Aimon, Cheng, Gjorgjieva, & Grunwald Kadow, 2022; Aimon et al, 2019; Woller, Bandow, Aimon & Grunwald Kadow, 2021) (Fig. S2A).…”
Section: Resultsmentioning
confidence: 99%
“…The functions of most of the other periesophageal neuropils like CAN, FLA, PRW, and the PLP are largely unknown in the honey bee and other insects. The availability of new fast live‐imaging techniques such as light‐field microscopy (Aimon et al., 2019, 2022) will eventually allow imaging of the entire brain in a behaving honey bee. Combinations with high‐resolution tracing and connectome studies of circuits at the ultrastructural level will promote our understanding of the complex structures in the central brain of this social insect.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies suggest that so far neglected neuropils in the cerebrum serve important functions in multisensory integration (Currier & Nagel, 2020). For example, whole brain imaging with novel microscopic techniques such as light field microscopy in behaving insects are beginning to elucidate the function of so far unknown neuropils in the central brain (e.g., Aimon et al, 2019Aimon et al, , 2022. However, the specific function and circuit architectures of cerebral neuropils, in many cases, still remain "terra incognita" (Ito et al, 2014).…”
Section: General Aspects Of a 3d Atlas Of The Honey Bee Central Brainmentioning
confidence: 99%