Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis

Asadpour, Nazanin; Shooshtari, Zahra; Kazemian, Mozhgan; Gholami, Mahdi; Vatanparast, Negin; Samieirad, Sahand

doi:10.1016/j.joms.2022.05.002

Cited by 16 publications

(13 citation statements)

References 33 publications

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“…Although nowadays there are treatments and therapies for joint dysfunction, currently there is no effective treatment for articular cartilage regeneration or osteoarthritis resolution produced by TMJD. 23 Use of PRP turns out to be a therapeutic method of easy manipulation, with minimal adverse reaction due to its autologous characteristic, it's an efficient treatment that allows reduction of painful symptoms in patients with TMJD. In rheumatology field PRP has been shown as an effective treatment for joint degenerative disorders, which regenerate chondrocyte, improve function, and decrease pain.…”

Section: Resultsmentioning

confidence: 99%

The use of platelet-rich plasma, hyaluronic acid, and botulinum toxin for the treatment of TMJ disorders

Plata¹

2023

JDHODT

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The temporomandibular joint (TMJ) is a synovial joint that connects the mandibular to the skull. Its main function is to facilitate the movement of the jaw and when it suffers any type of damage or injury, it leads to a decrease in mobility and pain in the area. This localized pain is called temporomandibular joint disorders (TMJD), and it can be caused by intraarticular or extraarticular disorders. The most common symptoms include acute pain, decreased mouth opening, tightening of the muscle, headache, and loss of joint function. Nowadays, there are treatments for temporomandibular joint dysfunction from surgical procedures up to less invasive methods, such as the use of splints. Platelet rich plasma (PRP), hyaluronic acid (HA) and botulinum toxin (BTX) injections have been categorized as a complement of primary treatment in TMJD, as well as decrease drug excess in patients. Due to their natural origin, PRP and HA can regenerate tissue in cases of cartilage degeneration, inhibit inflammation, slow down the progression of osteoarthritis and increase the production of natural lubricating fluid in the joint. Its intra-articular application reduces pain due to lubrication and nutrition to the avascular areas of the disc and condylar cartilage. Botulinum toxin (BTX) has been used for years in the medical and cosmetic field, but its use in TMJD refers to injections specifically within masseter muscle, with the objective to reduce the muscular tension TMJ overload, therefore, pain decreases, and movement increases. Over the years these less invasive methods have been increasing in the medical area due to the great pain management in the neuro-muscular and articular complex.

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Section: Resultsmentioning

confidence: 99%

The use of platelet-rich plasma, hyaluronic acid, and botulinum toxin for the treatment of TMJ disorders

Plata¹

2023

JDHODT

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“…Added to this, the authors Asadpour et al 2022 [22] evaluated, through a randomized clinical study, the efficacy of PRP and HA injection after arthrocentesis in individuals with TMJOA. Healthy adults diagnosed with TMJOA who were initially treated with non-surgical methods but did not respond participated in this study.…”

Section: Clinical Findings -Tmjoa and Prp Treatmentmentioning

confidence: 99%

Isolate or combined use of platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis: a concise systematic review

Manna¹,

Costa²,

Filho³

et al. 2023

MedNEXT

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Introduction: In the context of temporomandibular disorders (TMD), temporomandibular joint osteoarthritis (TMJOA) is a common disease in the oral and maxillofacial regions, as well as being the most severe type. The incidence of TMD is high, affecting approximately 5%-12% of the population. There is evidence for the potential superiority of intra-articular platelet-rich plasma (PRP) injections in patients with TMJOA. Objective: This study aimed to carry out a systematic review to highlight the main clinical outcomes of the minimally invasive treatment of osteoarthritis of the temporomandibular joint through the injectable use of platelet-rich plasma. Methods: The research and development of the work were carried out from December 2022 to March 2023 in the Scopus, PubMed, Science Direct, and Scielo databases, using scientific articles from 2011 to 2022, following the PRISMA rules. The quality of the studies was based on the GRADE instrument and the risk of bias by the Cochrane instrument (Funnel Plot). Results and Conclusion: It was found 134 studies that underwent eligibility analysis. The final sample had 48 eligible studies and only 25 studies were described in the systematic review. Most studies showed homogeneity in their results, with X2 =91.2% >50%, with p<0.05. The symmetrical funnel plot did not suggest a risk of bias among studies with small sample sizes. Based on the objective of the present study, important clinical outcomes of the treatment of osteoarthritis of the temporomandibular joint were evidenced through the injectable use of platelet-rich plasma, alone or in combination with other types of treatment. However, it was observed that despite the extensive literature on the use of PRP in the treatment of joint disorders, its application in TMD is still largely unexplored.

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“…[11][12][13] Among the minimally invasive techniques, intra-articular (IA) injections of sodium hyaluronate, including hyaluronic acid (HA), have gained attention as a potentially effective approach, also in combination with joint arthrocentesis and lavage. [14][15][16] HA is a linear polysaccharide physiologically found in synovium, vitrous humour and connective tissue. 17,18 The rationale for HA viscosupplementation lies in HA action as chondroprotective drug for anti-inflammatory and lubrication purposes, able to decrease mechanical wear, promote the tissue repair process in the cartilage and to induce an endogenous synthesis of acid by the synovial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Among the minimally invasive techniques, intra‐articular (IA) injections of sodium hyaluronate, including hyaluronic acid (HA), have gained attention as a potentially effective approach, also in combination with joint arthrocentesis and lavage 14–16 . HA is a linear polysaccharide physiologically found in synovium, vitrous humour and connective tissue 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid injections for pain relief and functional improvement in patients with temporomandibular disorders: An umbrella review of systematic reviews

Agostini,

Ferrillo,

Bernetti

et al. 2023

J of Oral Rehabilitation

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BackgroundTemporomandibular disorders (TMD) are the main cause of chronic facial pain, and intra‐articular (IA) injections of hyaluronic acid (HA) are commonly performed.ObjectivesThis umbrella review of systematic reviews aimed at analysing the effectiveness of HA injections on pain and functional outcomes in patients affected by TMD.MethodsPubMed, Cochrane Library and PEDro were systematically searched from inception until 17 January 2023 to identify systematic reviews evaluating the effects on pain and functional outcomes of HA IA injections. PROSPERO registration number: CRD42022382586.ResultsOut of 316 papers suitable for title/abstract screening, 18 articles were included in the umbrella review. Thirteen studies included only randomized controlled clinical trials (RCTs). The included systematic reviews reported no statistically significant differences between HA and corticosteroids, whereas platelet derivates seem to have good results in pain relief. The literature did not show severe adverse events, except for mild pain in the site of injection. Concerning the quality assessment of the 18 systematic reviews, 2 (11.11%) had a high quality, 3 (16.67%) a moderate quality, 7 (38.89%) a low quality and 6 (33.33%) a critically low quality.ConclusionsTaken together, findings of this umbrella review showed intriguing effects of IA HA injections in terms of reduction of pain intensity and improvement of functioning in patients affected by TMD. Furthermore, there is no agreement on the effectiveness of a combination of arthrocentesis or arthroscopy with IA HA injections. Although the literature showed these positive results after IA HA injections, the overlapping of primary studies in the systematic reviews included might have affect our results, such as the very low quality of the papers. Thus, further RCTs are needed to confirm the efficacy of IA injections of HA on pain relief in patients with TMD.

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Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis

Cited by 16 publications

References 33 publications

The use of platelet-rich plasma, hyaluronic acid, and botulinum toxin for the treatment of TMJ disorders

The use of platelet-rich plasma, hyaluronic acid, and botulinum toxin for the treatment of TMJ disorders

Isolate or combined use of platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis: a concise systematic review

Hyaluronic acid injections for pain relief and functional improvement in patients with temporomandibular disorders: An umbrella review of systematic reviews

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