According to results of our preliminary study, intermaxillary elastics to miniplates might have a promising effect as an alternative for face mask therapy in maxillary protraction of cleft lip and palate patients.

Aim: This study aimed to evaluate the frequency and distribution of impacted teeth and the associated pathologies. Materials and Methods: In this descriptive cross-sectional study, 10,000 panoramic radiographs of patients referred to a private radiology center and the radiology department of the School of Dentistry of Mashhad University of Medical Sciences were assessed from 2009 to 2012. All the radiographs were observed by an oral and maxillofacial radiologist, The number, position and inclination of impacted teeth and the associated pathologies were recorded. Results: Of 10,000 radiographs, 3,374 impacted teeth were observed. Third molar was the most prevalent impacted tooth of both jaws (95%), followed by canine, second premolar, second molar, and lateral incisor and first premolar teeth. The vertical position accounted for 36% of all impacted third molars positions, followed by mesioangular (30%), distoangular (22%), horizontal (11%), and buccolingual (1.5%) positions. The most common pathological feature related to impacted teeth was adjacent dental caries (64.7%). Moreover, root resorption of the adjacent tooth (0.6%) and increased follicular space (0.5%) were among the observed complications. Conclusion: In this study, the prevalence of tooth impaction was 33.74%, and the most common impacted teeth were vertically angulated third molars, accounting for most of the cases. In addition, adjacent dental caries was the most prevalent related pathology.

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Objective: Using an experimental rat model, the efficacy of injected Onabotulinum Toxin A (BoNT-A) versus topical Mitomycin C in surgical wound healing of rat lip defects was evaluated. Methods and Materials: Sixty-seven male Wister rats received a triangular cut (7 × 7 × 4 mm) on their upper lip. Then they were divided randomly into 4 equal groups: group A (topical Mitomycin C plus injected BoNT-A); group B (topical Mitomycin C); group C or control group (saline solution) and group D (injected (BoNT-A). After 3 months, the animals were euthanized and scars were evaluated using hematoxylin and eosin and Masson's trichrome. For qualitative analysis, inflammatory cell density, new capillary formation, fibroblast proliferation, and collagen deposition were reported using relative ranks from 0 to 3 (absence, mild, moderate, marked). Data were analyzed by post hoc and Kruskal–Wallis tests. The significance level was P < 0.05. Result: Mean collagen deposition values and fibroblast proliferation in the 4 groups showed statistically significant differences with each other (P value < 0.001). A significant difference between group A and controls existed for fibroblast proliferation (median 1 versus 2, P value < 0.001); also, collagen deposition (median 1 versus 2, P value < 0.001). A significant difference existed between the control and group D (median 2 versus 1, P value = 0.004); also, group A and B (median 1 versus 2, P value = 0.002) for collagen deposition. However, no significant differences existed between the 4 groups regarding inflammatory cells and angiogenesis (P value > 0.05). Conclusion: Local injection of BoNT-A plus Mitomycin C followed by BoNT-A alone provided less collagen formation and fibroblastic proliferation in the healing lip defect in a rat model.