Combined radiation and drugs: The effect of intra-arterial chemotherapy followed by radiotherapy in head and neck cancer

Arcangeli, Giorgio; Nervi, Carlo; Righini, R.; Creton, Giovanni; Mirri, M.A.; Guerra, Antonio Puglisi

doi:10.1016/s0167-8140(83)80013-9

Cited by 53 publications

(9 citation statements)

References 7 publications

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“…However, oral cancer patients have been a subset of larger study populations and, therefore, calculation could not be estimated appropriately. Arcangeli et al (1983) treated 72 head and neck cancer patients (stages 2 -4) with retrograde continuous IA local perfusion with methotrexate (3 -5 mg day À1 , up to an overall dose of 90 -120 mg) before definitive radiotherapy. Randomisation was against radiotherapy alone, and the complete study population comprised 142 patients.…”

Section: Discussionmentioning

confidence: 99%

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Kovács

2004

Br J Cancer

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Intra-arterial (IA) chemotherapy for curative treatment of head and neck cancer experienced a revival in the last decade. Mainly, it was used in concurrent combination with radiation in organ-preserving settings. The modern method of transfemoral approach for catheterisation, superselective perfusion of the tumour-feeding vessel, and high-dose (150 mg m À2 ) administration of cisplatin with parallel systemic neutralisation with sodium thiosulphate (9 g m À2 ) made preoperative usage feasible. The present paper presents the results of a pilot study on a population of 52 patients with resectable stage 1 -4 carcinomas of the oral cavity and the oropharynx, who were treated with one cycle of preoperative IA chemotherapy executed as mentioned above and radical surgery. There have been no interventional complications of IA chemotherapy, and acute side effects have been low. One tracheotomy had to be carried out due to swelling. The overall clinical local response has been 69%. There was no interference with surgery, which was carried out 3 -4 weeks later. Pathological complete remission was assessed in 25%. The mean observation time was 3 years. A 3-year overall and disease-free survival was 82 and 69%, respectively, and at 5 years 77 and 59%, respectively. Survival results were compared to a treatment-dependent prognosis index for the same population. As a conclusion, it can be stated that IA high-dose chemotherapy with cisplatin and systemic neutralisation in a neoadjuvant setting should be considered a feasible, safe, and effective treatment modality for resectable oral and oropharyngeal cancer. The low toxicity of this local chemotherapy recommends usage especially in stage 1 -2 patients. The potential of survival benefit as indicated by the comparison to the prognosis index should be controlled in a randomised study.

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Section: Discussionmentioning

confidence: 99%

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Kovács

2004

Br J Cancer

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“…This left 23 randomised controlled trials with survival data (Arcangeli et al, 1983;Cachin et al, 1977;Ervin et al, 1987;Fazekas et al, 1980;Fu et al, 1987;Gollin et al, 1972;Gupta et al, 1987;Head and Neck Contracts Program, 1987;Holoye et al, 1985;Hussey & Abrams, 1975;Knowlton et al, 1975;Lo et al, 1976;Martin et al, 1986;Nissenbaum et al, 1984;Pearlman et al, 1985;Petrovich et al, 1981;Rentschler et al, 1987;Schuller et al, 1988;Stefani et al, 1971;Stefani & Chung, 1980;Stell et al, 1983;Stolwijk et al, 1983;Taylor et al, 1985;Toohill et al, 1987;Vermund et al, 1985 Gollin et al (1972) and a subgroup of patients with tumours of the oral cavity and oropharynx, with additional patients, was later reported by Lo et al (1976). The data for tumours of the mouth and oropharynx are taken from the latter paper, and those for other sites from the former, but the two are otherwise treated as one trial.…”

Section: Methodsmentioning

confidence: 99%

“…Nine papers gave details of toxicity, with no grading scheme, eight papers dismissed it in a few words, e.g. 'mild and transient' (Arcangeli et al, 1983), and four did not mention it at all. No paper used the scheme recommended by the WHO (Miller et al, 1981).…”

Section: Toxicitymentioning

confidence: 99%

Adjuvant chemotherapy in head and neck cancer

Stell

1992

Seminars in Radiation Oncology

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“…Arcangeli et al (10) conducted a randomized trial on induction IA chemotherapy to ascertain whether a prior reduction in tumour size by drugs could affect the final outcome of tumours treated with radiation. One hundred and forty-two patients with head and neck cancer (oropharynx, maxillary antrum and intra-oral) were randomized for the study.…”

Section: Ia Chemotherapy As Induction Chemotherapymentioning

confidence: 99%

Intra-arterial chemoradiotherapy for head and neck cancer

Homma¹,

Onimaru²,

Matsuura³

et al. 2015

Jpn. J. Clin. Oncol.

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Intra-arterial chemotherapy has been used to treat localized malignant neoplasms in patients with head and neck cancer for over 50 years as the head and neck region is particularly well suited to regional chemotherapy. Early intra-arterial chemotherapy did not prove its efficacy. In addition, the additional complications associated with establishing and maintaining arterial access have further dampened enthusiasm for this approach. Subsequent significant advances in vascular radiology techniques and the development of new devices, such as fluoroscopy units and angiographic catheters, have made possible safe, accurate and repeated superselective intra-arterial chemotherapy. Intra-arterial infusion of high-dose cisplatin with systemic neutralization by intravenous sodium thiosulfate (RADPLAT) is a theoretically attractive approach to the treatment of advanced head and neck cancer. However, a Dutch trial comparing intra-arterial and intravenous chemoradiotherapy for advanced head and neck cancer showed that RADPLAT was not superior to intravenous chemoradiotherapy. Therefore, further investigation of RADPLAT, including the refinement of the indications for its application, is needed.

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Combined radiation and drugs: The effect of intra-arterial chemotherapy followed by radiotherapy in head and neck cancer

Cited by 53 publications

References 7 publications

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Adjuvant chemotherapy in head and neck cancer

Intra-arterial chemoradiotherapy for head and neck cancer

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