Combined CD44, c‐MET, and EGFR expression in p16‐positive and p16‐negative head and neck squamous cell carcinomas

Abstract

High CD44 expression is associated with high c-MET expression, p16-negative tumors, and EGFR-positive tumors. The combination of these markers predicts for poor prognosis in HNSCC patients treated with chemoradiation.

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

“…In accordance with previously published studies, combined analysis of expression profiles showed that high expression of both, CD44 and EGFR, is significantly associated with p16 negativity. Moreover, significant association between CD44+ and EGFR+ was confirmed by independent test, supporting suggested interactions between CD44 and EGFR.…”

“…Our findings were supported by recent work of Cohen et al, which introduced so‐called gross staining designation and reported worse OS in patients displaying universal gross staining designation defined by the presence of 90% of tumor showing the same localization of membrane or cytoplasmic CD44 expression. Negative prognostic effect of high expression of CD44 in oral and oropharyngeal cancers in terms of disease‐free survival and/or OS was also presented by Lindquist et al and Nasman et al In our study, patients with CD44+ OPSCC displayed significantly shorter OS and worse LRC on univariate analysis, supporting the results of Baschnagel et al and Motegi et al who reported high CD44 expression as a predictor for worse LRC, PFS and OS, and PFS and LRC rates significantly longer in CD44− patients, respectively.…”

“…Despite the huge number of studies evaluating the new prognostic biomarkers of head and neck cancer including OPSCC, only few previous studies analyzed their combined immunoprofiles …”

WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer

“…After title and abstract checking, 36 studies remained for the further evaluating in details, in which 15 articles were excluded for there were no enough data to calculate the survival rate [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27], one article was removed because of duplication [28]. So, a total of 20 publications were fulfilled the eligibility criteria [5][6][7][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

An immunohistochemical score to predict the outcome for oral squamous cell carcinoma

“…Earlier studies have previously described the relation of these markers with survival. EGFR high expression has been associated with a decreased survival rate of OSCC . In particular, EGFR cell sublocalisation could be an important aspect and related to decreased survival.…”