Combined St. Thomas and Histidine-Tryptophan-Ketoglutarat Solutions for Myocardial Preservation in Heart Transplantation Patients

Lee, K.C.; Chang, Chung-Yi; Chuang, Yi-Cheng; Sue, Sung-How; Yang, Hou-Sheng; Weng, Chi Feng; Lee, Y.T.; Huang, Wen-Sheng; Chen, I.C.; Wei, Jeng

doi:10.1016/j.transproceed.2011.11.010

Cited by 8 publications

(13 citation statements)

References 17 publications

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“…Owing to characteristics of heart transplantation, there is a lack of high‐quality randomized clinical trials to determine the influence of the preservation fluids on graft function and survival. Such trials and studies are often underpowered to identify optimal regimens in these preservation solutions .…”

mentioning

confidence: 99%

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Guo²,

Liu³

et al. 2015

Artificial Organs

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Organ preservation solution has been designed to attenuate the detrimental effects during the ischemic period. The aim of this study was to systematically evaluate the evidence comparing preservation solutions for heart preservation. Studies were searched in PubMed, Embase, the Cochrane Library, the Transplant Library, and the International Clinical Trials Registry Platform. The primary outcomes were patient survival and donor heart dysfunction. The secondary outcomes were in-hospital mortality and enzyme gene expression. The University of Wisconsin solution (UW) was associated with a significantly improved survival at 30 days and 90 days (hazard ratio = 1.16, 95% confidence interval [CI] = 1.11-1.22, P < 0.00001; risk difference [RD] = 0.03, 95% CI = 0.01-0.05, P = 0.002), compared with Celsior. Hearts preserved with UW exhibited less ischemic necrosis than those preserved with Celsior (RD = -0.07, 95% CI = -0.08 to 0.05, P < 0.00001). UW was associated with better survival compared with histidine-tryptophan-ketoglutarate solution (HTK). There was no statistical difference in donor heart dysfunction and in-hospital mortality outcomes when comparing HTK with Celsior solution. During static cold storage preservation, this study suggests that UW solution has better clinical outcomes for heart transplantation compared with the other two organ preservation solutions. Besides, the protective effect of Celsior solution is similar to HTK solution in donor heart preservation.

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mentioning

confidence: 99%

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Guo²,

Liu³

et al. 2015

Artificial Organs

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“…In addition to using a static cold storage system, our center utilizes a CPS administered immediately before implantation, which is regarded as simple and cost-effective. A few articles have described similar methods [4][5][6], but their effects remain uncertain.…”

Section: Kjtcvs Discussionmentioning

confidence: 99%

“…However, whether supplemental cardioplegia infusion has any https://doi.org/10.5090/kjtcs.19.091 pISSN: 2233-601X eISSN: 2093-6516 Korean J Thorac Cardiovasc Surg. Published online October 13, 2020 KJTCVS potential benefit remains to be determined [4][5][6]. We therefore sought to evaluate the safety and possible benefits of this strategy.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Supplemental Cardioplegia Infusion before Anastomosis in Patients Undergoing Heart Transplantation with Long Ischemic Times

Kim

Jung

Yang

et al. 2020

Korean J Thorac Cardiovasc Surg

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This paper was presented at the 50th Fall Conference of the Korean Society for Thoracic and Cardiovascular Surgery. Background: Prolonged ischemic time is a risk factor for primary graft dysfunction in patients who undergo heart transplantation. We investigated the effect of a supplemental cardioplegia infusion before anastomosis in patients with long ischemic times. Methods: We identified 236 consecutive patients who underwent orthotopic heart transplantation between February 2010 and December 2014. Among them, the patients with total ischemic times of longer than 3 hours (n=59) were categorized based on whether they were administered a complementary cardioplegia solution (CPS) immediately before implantation (CPS+, n=30; CPS−, n=29). Results: The mean total ischemic times in the CPS+ and CPS− groups were 238.1±30.1 minutes and 230.1±28.2 minutes, respectively (p=0.3). The incidence of left ventricular primary graft dysfunction (CPS+, n=6 [20.0%]; CPS−, n=5 [17.2%]; p=0.79) was comparable between the groups. In the Kaplan-Meier survival analysis, no significant difference in overall survival at 5 years was observed between the CPS+ and CPS− groups (83.1%±6.9% vs. 89.7%±5.7%, respectively; log-rank p=0.7). No inter-group differences in early mortality (CPS+, n=0; CPS−, n=1 [3.4%]; p=0.98) or complications were observed. Conclusion: The additional infusion of a cardioplegia solution immediately before implantation in patients with longer ischemic times is a simple, reproducible, and safe procedure. However, we did not observe benefits of this strategy in the present study.

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“…Lee и соавт. [7] считают безопасным сочетание кардиоплегии, вызванной раствором Св. Томаса, с раствором гистидин-триптофан-кетоглутарата при условии средней краткосрочной выживаемости после ишемического инсульта порядка 225 мин (почти как и при использовании других методов) при низком перфузионном давлении для сохранения сердца донора.…”

Section: Discussionunclassified

The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats

et al. 2015

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Objective: The aim of this experimental study was to examine the effect of the antioxidant drug U-74389G in a rat model of hypoxia reoxygenation using the previously established protocol. Effects of treatments were evaluated by magnesium (Mg2+) levels in blood. Methods: Nonrandomized controlled study was performed. Mg2+ levels were determined in 60 min (groups A and C) and 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. Results: 40 rats 1618 weeks old of a mean weight of 2312 g were employed in the study. It is demonstrated that U-74389G administration did not alter the Mg2+ levels (decrease in Mg2+ concentration was 0.282.75%; p =0.917). Reoxygenation non-significantly increased the Mg2+ levels by 4.272.66% (p =0.107). Together, the U-74389G administration and reoxygenation non-significantly increased the Mg2+ levels by 0.361.64% (p =0.823). Conclusion: U-74389G administration, alone or in concert with reoxygenation did not significantly affect Mg2+ level in blood after experimental hypoxia in rats.

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Combined St. Thomas and Histidine-Tryptophan-Ketoglutarat Solutions for Myocardial Preservation in Heart Transplantation Patients

Cited by 8 publications

References 17 publications

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

The Effect of Supplemental Cardioplegia Infusion before Anastomosis in Patients Undergoing Heart Transplantation with Long Ischemic Times

The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats

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